学科分类
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500 个结果
  • 简介:AIM:Toinvestigatethetreatmentstatusandprognosisofspace-occupyinglacrimalglandlesionsatonetertiaryeyecenterinChina.·METHODS:Aretrospectiveclinicalstudywasperformedon95patientswithspace-occupyinglesionsofthelacrimalglandsurgicallytreatedattheEye&ENTHospitalofFudanUniversityfrom2003to2007.Thereviewedclinicaldataincludedage,gender,sideofthelesion,durationofsignsandsymptoms,histopathologicaldiagnosis,treatmentmodality,recurrence(local,regional,anddistantmetastasis)andsurvival.·RESULTS:Ofthe95cases(99eyes),pleomorphicadenomaswerethemostcommonlesions(43cases),followedbylymphoiddisorders(14),inflammatorypseudotumors(11),carcinomaex-pleomorphicadenomas(11),andadenoidcysticcarcinomas(ACC,6).Therewere8patientswithrelapsedpleomorphicadenomas.Fiveofthese8caseshadmalignantpathologicalchanges.AllpatientswithACChadmetastasisandthreeofthemdiedduringtheirfollow-up.·CONCLUSION:Ourstudyindicatedthatthemostcommonlacrimalglandlesionswerepleomorphicadenomas.Multiplerecurrenceandsurgicalproceduresmayincreasetheriskoftumorprogression.ACChadahighincidenceoftumormetastasisandapoorprognosis.

  • 标签: LACRIMAL GLAND lesions PLEOMORPHIC ADENOMAS ADENOID
  • 简介:AIM:Toevaluatetheefficacyofintralesionalradiofrequencyablationinthetreatmentofperiorbitalsyringomas.·METHODS:Wetriedtheintralesionalradiofrequencyablationfor64patientswithperiorbitalsyringomasfrom2007to2011.Theoperationwasperformedunder2.5loupemagnifications.Thehandpiecewasassembledwithaneedleelectrodeandconnectedtotheradiofrequencyablationapparatus.Theelectrodewastheninsertedintothetargetlesionsindermisanddeliveringinjurytothebaseofthesetumors.Resultswereassessedclinicallybycomparingpre-andpost-treatmentphotographsandpatientsatisfactionrates.·RESULTS:Clinicalimprovementincreasedwitheachsubsequenttreatmentsession.Thepercentofpatientswhoseclinicimprovementgradewere≥3aftereachsessionwasrespectively71.9%(Session1),83.3%(Session2),and100%(Session3).Thestatisticalresultsindicatedtheconcordanceoftheclinicalassessmentandthesatisfactionlevelofpatients(kappa=0.78ofthesession1;kappa=0.82ofthesession2).Themajorityofpatientshadgoodorexcellentcosmeticresults.Postoperatively,therewerenopermanentsideeffectsorrecurrences.·CONCLUSION:Asanewtechniqueofminimallyinvasion,theintralesionalradiofrequencyablationwasfoundtobeaneffective,inexpensive,highlypreciseandsafewayoftreatingperiorbitalsyringomas.

  • 标签: PERIORBITAL syringomas RADIOFREQUENCY ablation TREATMENT
  • 简介:AIM:Toreporttheeffectivenessandsafetyofprimary23-Gauge(G)vitreoretinalsurgeryforrhegmatogenousretinaldetachment(RRD).·METHODS:Inthisretrospectivestudy,49eyesof49consecutivepatientswhounderwentprimary23-Gtransconjunctivalsuturelessvitrectomy(TSV)forRRDbetweenJanuary2007andJuly2009atourinstitutionwereevaluated.·RESULTS:Meanfollow-uptimewas8.9±7.7months(1-28months).Retinalreattachmentwasachievedwithasingleoperationin47(95.9%)of49eyes.Intwoeyes(4.1%),retinalredetachmentduetonewbreakswassuccessfullytreatedwithreoperationusingthe23-GTSVsystem.MeanlogMARvisualacuitywas2.01±0.47preoperativelyand1.3±0.5postoperatively(P<0.001,Pairedt-test).Meanpreoperativeintraocularpressure(IOP)was14.1±2.8mmHg.MeanpostoperativeIOPwas12.3±3.6mmHgat1day,13.1±2.1mmHgat1week,14.3±2.2mmHgat1month.Iatrogenicperipheralretinalbreakwasobservedin1eye(2.0%)intraoperatively.Nosutureswererequiredtoclosethescleralorconjunctivalopenings,andnoeyesrequiredconvertionofsurgeryto20-Gvitrectomy.·CONCLUSION:Primary23-GTSVsystemwasobservedtobeeffectiveandsafeinthetreatmentofRRD.

  • 标签: PARS plana VITRECTOMY RETINAL DETACHMENT rhegmatogenous
  • 简介:AIM:Toevaluatetheefficacyandsafetyofcornealcollagencrosslinking(CXL)topreventtheprogressionofpost-laserinsitukeratomileusis(LASIK)cornealectasia.·METHODS:Inaprospective,nonrandomized,single-centrestudy,CXLwasperformedin20eyesof11patientswhohadLASIKformyopicastigmatismandsubsequentlydevelopedkeratectasia.Theprocedureincludedinstillationof0.1%riboflavin-20%dextranesolution30minutesbeforeUVAirradiationandevery5minutesforanadditional30minutesduringirradiation.Theeyeswereevaluatedpreoperativelyandat1-,3-,6-,and12-monthintervals.Thecompleteophthalmologicexaminationcompriseduncorrectedvisualacuity,bestspectacle-correctedvisualacuity,endothelialcellcount,ultrasoundpachymetry,cornealtopography,andinvivoconfocalmicroscopy.·RESULTS:CXLappearedtostabiliseorpartiallyreversetheprogressionofpost-LASIKcornealectasiawithoutapparentcomplicationinourcohort.UCVAandBCVAimprovementswerestatisticallysignificant(P<0.05)beyond12monthsaftersurgery(improvementof0.07and0.13logMARat1year,respectively).Meanbaselineflattestmeridiankeratometryandmeansteepestmeridiankeratometryreduction(improvementof2.00and1.50diopters(D),respectively)werestatisticallysignificant(P<0.05)at12monthspostoperatively.At1yearafterCXL,meanendothelialcellcountdidnotdeteriorate.Meanthinnestcorneapachymetryincreasedsignificantly.·CONCLUSION:Theresultsofthestudyshowedalong-termstabilityofpost-LASIKcornealectasiaaftercrosslinkingwithoutrelevantsideeffects.Itseemstobeasafeandpromisingproceduretostoptheprogressionofpost-LASIKkeratectasia,therebyavoidingordelayingkeratoplasty.

  • 标签: CROSSLINKING KERATOCONUS ultraviolet CORNEA ECTASIA laser
  • 简介:上海交通大学医学院(原上海第医科大学)附属仁济医院是所历史悠久甲等教学医院(建院于1844年),耳鼻咽喉科和我国大多数兄弟医院样,多年来直从事如急慢性中耳炎、急慢性咽、喉炎、扁桃炎、耳鸣、耳聋等临床常见病、多发病医疗、教学及研究工作,近年来由于疾病谱变化我们除常规传统工作之外,每年对头颈肿瘤患者诊治也逐渐增多。2005年仅甲状腺肿瘤外科手术治疗达500多例,近10余年总数超过5000例,约占本科手术总量45%。作为以传统耳鼻咽喉科为主甲等医院中员,开始每年10余例甲状腺肿瘤手术到目前每年500余例,并进行涎腺肿瘤外科、头颈部先天性肿瘤、头颈部外伤治疗,开展了颈胸联合、颅鼻联合手术等工作,逐渐发展成为具初步规模耳鼻咽喉头颈外科,我们走过了10余年历程,有了些感受,现就有关耳鼻咽喉头颈外科医师进行甲状腺肿瘤外科治疗若干体会与从事相关工作同道们进行交流、切磋。

  • 标签: 三级甲等医院 耳鼻咽喉科 甲状腺肿瘤 综合性医院 若干体会 外科治疗
  • 简介:目的:观察波前像差引导LASIK波前像差优化LASIK对全眼高阶像差在0.3滋m以下近视散光眼疗效差异。方法:前瞻性病例系列研究。收集在我院就诊拟行LASIK手术近视散光患者30例60眼。每位患者随机选取眼接受波前像差引导LASIK,对侧眼接受波前像差优化LASIK。术后6mo观察患者视力、屈光度、全眼高阶像差及暗光下对比敏感度。采用配对样本t检验和字2检验进行统计学分析。结果:术后6mo,波前像差引导组波前像差优化组分别有93%及90%术眼裸眼视力逸5.0,两组术后等效球镜值在±0.50D范围内比例分别为87%及83%,差异无统计学意义(P〉0.05)。两组术后均未出现最佳矫正视力丢失2行或以上情形。两组术后总高阶像差、球差、彗差均较术前增大(P〈0.01),但增幅在两组间无统计学差异(P〉0.05)。两组术后6mo暗光下对比敏感度在各个空间频率均恢复至术前水平,差异无统计学意义(P〉0.05)。结论:对术前全眼高阶像差小于0.3滋m近视散光眼,波前像差引导LASIK波前像差优化LASIK对术后视力、屈光度、全眼高阶像差及对比敏感度影响无明显差异。

  • 标签: 激光原位角膜磨镶术 波前像差 近视
  • 简介:AIM:Anaerobicbacteriacancauseocularinfections.WetestedtheOxyPlateTMAnaerobicSystem(OXY)toisolatepertinentanaerobicbacteriathatcancauseoculardisease.METHODS:OXY,whichdoesnotrequiredirectanaerobicconditions(i.e.bags,jars),wascomparedtoconventionalisolationofincubatingculturemediainanaerobicbags.Standardcoloniescountswereperformedonanaerobicocularbacterialisolatesunderaerobicandanaerobicconditions(anaerobicbags)usingagarmedia:1)OXY(aerobiconly),2)5%sheepblood(SB),3)Chocolate,and4)Schaedler.Thebacteriatestedwerede-identifiedocularisolatesculturedfromendophthalmitisanddacryocystitisthatinclude10Propionibacteriumacnesand3Actinomycesspecies.Thecolonycountsforeachbacteriaisolate,oneachculturingcondition,wererankedfromlargesttosmallest,andnon-parametricallycomparedtodeterminethebestculturingcondition.RESULTS:Allanaerobicconditionswerepositiveforalloftheanaerobicisolates.SBandSchaedler’sagarunderaerobicconditionsdidnotsupportthegrowthofanaerobicbacteria.SparsegrowthwasnotedonchocolateagarwithPropionibacteriumacnes.Asananaerobicsystem,SBinananaerobicbagisolatedhighercolonycountsthanOXY(P=0.0028)andchocolateagar(P=0.0028).CONCLUSION:AlthoughOXYdidnottesttobemoreefficientthanotheranaerobicsystems,itappearstobeareasonablealternativeforisolatinganaerobicbacteriafromocularsites.Theuseofanagarmediuminaspeciallydesignedplate,withouttherequirementofananaerobicbag,renderedOXYasanadvantageoverotheranaerobicsystems.

  • 标签: ANAEROBIC BACTERIA BACTERIAL isolation ENDOPHTHALMITIS DACRYOCYSTITIS
  • 简介:AIM:ToIntroduceanewspecializedvisualacuitychartforamblyopicchildrenaged3-5yearsoldanditsclinicalapplications.METHODS:ThenewvisualacuitychartandnotationsweredesignedbasedonWeber-Fechnerlaw.Theoptotypeswereredagainstawhitebackgroundandwerespeciallyshapedfourbasicgeometricsymbols:circle,square,triangle,andcross.Aregulargeometricprogressionoftheoptotypesizesanddistributionwasemployedtoarrangein14lines.Theprogressionrateoftheoptotypesizebetweentwolineswas1.2589andthetestingdistancewas3m.VisualacuityscorecouldberecordedaslogMARnotationordecimalnotation.Agestratifieddiagnosticcriteriaforamblyopiaestablishedbyconsensusstatementondiagnosisofamblyopia(2011)amongmembersoftheStrabismusandPediatricOphthalmologyGroup,OphthalmologySociety,ChineseMedicalAssociation(SPOGOSCMA)wereillustratedinthenewvisualacuitychart.RESULTS:Whenassessingvisualacuityinchildrenaged3-5yearsold,thisnewvisualacuitychartthatconsistsoffoursymmetricalshapes(triangle,square,cross,andcircle)overcameaninabilitytorecognizethelettersofthealphabetanddifficultiesindesignatingthedirectionofblackabstractsymbolssuchasthetumbling’E’orLandolt’C’,whichthesubjectswerepronetoloseinterestin.Thevisualacuityscoremayberecordedindifferentnotations:decimalacuityandlogMAR.Thesetwonotationscanbeeasilyconvertedeachotherintheneweyechart.Themeasurementsofthisnewchartnotonlyshowedasignificantcorrelationandagoodconsistencywiththeinternationalstandardlogarithmicvisualacuitychart(r=0.932,P<0.01),butalsoindicatedahightest-retestreliability(89%ofretestscoreswerewithin0.1logMARunitsoftheinitialtestscore).CONCLUSION:Theresultsofthisstudysupportthevalidityandreliabilityofdistancevisualacuitymeasurementsusingtheneweyechartinchildrenaged3to5yearsoverawiderangeofvisualacuities,andtheneweyechartisgreatforearl

  • 标签: amblyopic CHILDREN Weber-Fcchner LAW INTERNATIONAL standard
  • 简介:目的:探讨术(白内障超声乳化吸除、后房型人工晶状植入联合小梁切除术)治疗青光眼合并白内障患者临床疗效。方法:青光眼合并白内障患者72例72眼行小梁切除联合白内障超声乳化吸除联合后房型人工晶状植入术,观察术后视力、眼压、滤过泡及并发症等情况。结果:术后72例72眼患者视力均有不同程度提高;术后眼压控制良好,术后3,18mo平均眼压分别为15.30±2.64mmHg和16.72±2.30mmHg,术后均无严重并发症。结论:小梁切除联合白内障超声乳化吸除联合后房型人工晶状植入术具有切口小,眼压控制良好,能获得较满意视力。

  • 标签: 超声乳化 人工晶状体植入 小梁切除术 青光眼 白内障
  • 简介:质量个难以描述及定义概念。人们对质量评定各有不同见解。拿出租车旅行来打个比方。你如何评定旅行质量?你评定时基于司机是否有礼貌还是车子豪华程度?或者以你安全到达目的标准?如果让你司机来评价同样场旅行质量,他们可能认为旅途中没有抛锚或没有被交通事故耽搁就是好。评定质量有很多不同标准,以那点为准取决于你角色。

  • 标签: 手术质量 白内障 交通事故 旅行 出租车 司机
  • 简介:·Thisisacasepresentationofaverybizarreopenglobetraumawithanteriorsegmentforeignbody-fishinghookstuckinthecorneaandiris.Complicationsduetothiskindofeyetraumamightbeveryhazardousandwithseriousimpactonvisualfunction.Wearerepresentingourapproachandexperienceofthreestepmanagementofthiskindofeyeinjury:first-extracttheforeignbody,closeandreconstructtheeyeball,second-fightinflammation,andthird-restorethevisualfunctionbycataractsurgery.·

  • 标签: eye TRAUMA ANTERIOR SEGMENT foreign body
  • 简介:目的探讨防盲活动中贫困白内障手术质量控制方法。方法年终检查时(距手术后最短时间个月,大部分都在术后月以上)设计了质量评估方案,即随机、按比例进行检查,包括按8%抽查病历,2%电话随访,0.5%现场入户检查。结果2009年我省贫困白内障手术任务13000例,实际完成13308例。手术方式主要为小切口非超声乳化白内障摘除及人工晶体植入术,其中8%病人采取了超声乳化手术。病历抽查:93%病历能按省卫生厅和省防盲办要求规范执行,其中观察术后矫正视力〉0.3达91.23%,人工晶体植入率97.82%。电话随访结果是老百姓对该项工程满意率达92.30%。现场入户调查结果,对手术效果(100分)评分98.87,对政府组织(100分)等评分99.98,现场视功能检查(包括日常生活对视力需求)评分(总分40分)37.43。术后并发症发生率﹤5%,主要表现为瞳孔变形和后发白内障。结论按定比例,随机采取病历检查、电话随访和现场入户相结合方法进行调查,是贫困白内障患者复明工程手术质量良好控制方法。

  • 标签: 白内障 手术 质量控制
  • 简介:AIM:ToinvestigatetheefficacyofFerrararings(FR)implantationinthetreatmentofkeratoconus.METHODS:Itwasaretrospectivecaseseriesdescriptivestudy.Thesamplewascomprisedof50patients79eyesdiagnosedwithprogressivekeratoconus.Thisincluded24(48%)malesand26(52%)femalesbetweentheageof13and44years.AllparticipantsunderwentsurgicalimplantationofFRintheperiodbetweenJanuary2009andSeptember2010atJordanUniversityHospital.Thoroughophthalmologicexaminationswereappliedtomeasurevitalvariablesforeachpathologicalconditionbeforeandaftersurgery.RESULTS:Findingsindicatedanoverallsignificantpostoperativeimprovementinbothuncorrectedvisualacuity(UCVA)andbestspectaclecorrectedvisualacuity(BSCVA)throughoutfollowupvisits.Moreover,resultsillustratedasignificantdecreaseinsphericalequivalent(SE)andkeratometricreadings(lower,higherandtheaverage).CONCLUSION:Surgicalinterventionstrategiesarebeingfrequentlydevelopedtomeettheneedsofpatientswithkeratoconus.TheimplantationofFerrararingshasproventobeasafeandfeasiblealternativeprocedureforthetreatmentofmild-moderatekeratoconusespeciallyforpatientswithcontactlensesintolerance.Wehavefoundthatthisprocedurehasimprovedvisualoutcomesinalleyesstudied.Nevertheless,furtherresearchisneededtoinvestigatelongtermoutcomes.

  • 标签: CORNEA KERATOCONUS Ferrara RINGS intracorneal RING
  • 简介:AIM:Toevaluatetheefficacy,safetyandstabilityofposteriorchamberphakicintraocularlensimplantationforthecorrectionofhighmyopia.METHODS:Retrospectivecasereviewof82eyes(43patients)undergoingimplantableColiamerlens(ICL)placementbyasinglesurgeon(Xiao-WeiGao)tocorrectpreoperativemeansphericalequivalentsbetween-9.00diopter(D)and-23.00D.Mainoutcomemeasuresincludeduncorrectedvisualacuity(UCVA),refraction,bestspectacle-correctedvisualacuity(BSCVA),endothelialcelldensity(ECD),intraocularpressure(IOP),lenstransparency,postoperativeuveitis.Visanteanteriorsegmentopticalcoherencetomography(AS-OCT)wasusedtomeasureanteriorchamberdepth(ACD)andthepositionofICL.RESULTS:Meanfollow-upwas6.54±3.26months(range3-12months).Predictabilityofthemanifestsphericalequivalent(SE)refractiontowithin±1.OODwasachievedin88%ofeyesand±0.50Din72.5%ofeyes.ThemeanpostoperativemanifestSErefractionwas-1.85±0.72D,with96.34%ofeyesmaintainingorgaining≥1line(s)ofBSCVA.Themean3-monthpostoperativeECDdecreasedbuthadnostatisticallydifferencecomparedwiththepreoperativeECD.Ofthe7eyes(8.54%)withamildtransientincreaseinintraocularpressure(upto30mmHg),nonerequiredasecondsurgicalprocedureorprolongedtopicalmedication.Therewasnolossoflenstransparency.Pigmentedprecipitateswereobservedin5eyes(6.09%).ThemeanpreoperativeACDmeasuredwithAS-OCTwas3.28±0.14mm,threemonthsaftersurgery,themeanACDwas2.45±0.22mm.Anteriorchamberdepthshowedastatisticallysignificantreduction.Oneeye(1.22%)hadICLspontaneousrotation,81eyes(98.78%)ofthelensremainedcorrectlycentered.CONCLUSION:TheimplantationofICLisaneffectivesurgicaloptionforthemanagementofhighmyopia.Butitslongtimeeffectandsafetystillneedmoretimetoprove.

  • 标签: PHAKIC INTRAOCULAR LENS LENS IMPLANTATION MYOPIA
  • 简介:AIM:Todescribethecharacteristicsofmodulationtransferfunction(MTF)ofanteriorcornealsurface,andobtainthethenormalreferencerangeofMTFatdifferentspatialfrequenciesandopticalzonesoftheanteriorcornealsurfaceinmyopes.·METHODS:Fourhundredeyesfrom200patientswereexaminedunderSIRIUScornealtopographysystem.PhoenisanalysissoftwarewasappliedtosimulatetheMTFcurvesofanteriorcornealsurfaceatverticalandhorizontalmeridiansatthe3,4,5,6,7mmopticalzonesofcornea.TheMTFvaluesatspatialfrequenciesof5,10,15,20,25,30,35,40,45,50,55and60cycles/degree(c/d)wereselected.·RESULTS:TheMTFcurveofanteriorcornealsurfacedecreasedrapidlyfromlowtointermediatefrequency(0-15cpd)atvariousopticalzonesofcornea,thevaluedecreasedto0slowlyathigherfrequency(>15cpd).Withtheincreaseoftheopticalzonesofcornea,MTFcurvedecreasedgradually.3)Intherangeof3mm-6mmopticalzonesofthecornea,theMTFvaluesmeasuredathorizontalmeridianweregreaterthanthecorrespondingvaluesathorizontalmeridianofeachspatialfrequency,thedifferencewasstatisticallysignificant(P<0.05).At7mmopticalzonesofcornea,theMTFvaluesmeasuredathorizontalmeridianwerelessthanthecorrespondingvaluesatverticalmeridianat10-60spatialfrequencies(cpd),andthedifferencewasstatisticallysignificantin25,30,35,40,45,50cpd(P<0.05).·CONCLUSION:MTFcanbeusedtodescribetheimagingqualityofopticalsystemsatanteriorcornealsurfaceobjectivelyindetail.

  • 标签: MODULATION TRANSFER FUNCTION OPTICAL quality CORNEA
  • 简介:目的探讨在规模化复明工程中应用小切口非超声乳化白内障手术环节控制。方法对1888例(1888眼)施行小切口白内障囊外摘除联合人工晶体植入术,分析手术流程及效果。结果术后第天时,裸眼视力〉=0.5者1056例;占55.93%;〉=0.3者396例,占20.97%;〈0.3者395例,占20.92%;〈0.05者41例,占2.17%。结论在基层条件下充分准备,优化技术管理,在简单条件下充分利用有限卫生资源,可让更多白内障患者脱盲。

  • 标签: 白内障 复明工程 脱盲
  • 简介:资料患者男性,35岁。因左侧颈部淋巴结肿大伴皮肤瘙痒半年余就诊。2014年10月血常规:嗜酸性粒细胞计数4.78×109/L,百分比为43.01%。入院体格检查:左侧颈部及双侧腹股沟可扪及多枚肿大淋巴结,最大约1.5cm×3.0cm,质中,表面光滑,活动可,无压痛。左侧额部可见索状隆起血管。入院血常规:嗜酸性粒细胞计数4.70×109/L,百分比达到35.8%。

  • 标签: 木村病 左侧颈部 颈部肿块 双侧腹股沟 左侧额 肿大淋巴结
  • 简介:AIM:TotrainTibetanmonkey(Macacathibetana)forintraocularpressure(IOP)measurementinconsciousstateandobtainnormalIOPinconsciousTibetanMacaque.·METHODS:Thetrainingwasbasedonaward-conditionedbehavior.Foodstimulationandhuman-animalinteractionwereusedinthistraining.·RESULTS:TrainedTibetanmonkeyscalmlyacceptedIOPmeasurementbytheTonoVet?誖reboundtonometerwithoutsedationoranesthesiaandtheirIOPvaluesweresimilartootherprimates.·CONCLUSION:Human-cultivatedThibetanmonkeysaretamable,andcanbeusedforbiomedicalresearchsuchasophthalmicresearchwithoutanesthesia.

  • 标签: MACACA thibetana DOMESTICATION CONSCIOUS INTRAOCULAR pressure
  • 简介:AIM:ToexploretheinhibitoryeffectofasustainedcyclosporinA(CsA)deliverymicrosphere(CsA-MS)onposteriorcapsularopacification(PCO)inrabbiteyesaftercataractextraction.·METHODS:TwentyNewZealandwhiterabbitsacceptedcataractextractionplusintraocularlensimplantationandtheirlefteyeswereintraoperativelyinjectedCsA-MSpreparedusingpolymerpolylactioglycolicacid(PLGA)asacarrierandtheirrighteyeswereinjectedwithemptyMS.Thechangesincornea,anteriorchamberreaction,intraocularpressure,PCOandCsAconcentrationinaqueoushumorwereexaminedpostoperativelyandalltheeyeswereenucleated3monthsaftersurgeryforhistopathologicalandmorphologicalexaminationwithlightmicroscopyandelectronmicroscopy.·RESULTS:Conjunctivalhyperemia,cornealedema,intraocularpressureandanteriorchamberresponseofexperimentalandcontroleyesweresimilar,whilePCOinCsAMSinjectedeyeswasgreatlyimprovedcomparedwiththatincontroleyes.PosteriorcapsulesinCsA-MSinjectedeyesweresmoothandlensepithelialcells(LEC)didnotproliferatesignificantly(P>0.05),whileLECinposteriorcapsuleofcontroleyeshaddifferentdegreesofproliferationandcorticalregeneration.LECinCsA-MSinjectedeyeswerenotfunctionallyactiveandunderwentapoptosis,whereasLECincontroleyeswerefunctionallyactive(F-test,P=0.025).Inaddition,thecornealultrastructureshowednodifferencesbetweenCsA-MSandMSinjectedeyes.CONCLUSION:CsA-MShashighbioavailabilityinrabbiteyesandcouldinhibitpostoperativePCOoccurrenceanddevelopmentduringthestudyperiod,suggestingthatCsA-MSmaybeapromising,effectiveandsafeadministrationroutetopreventPCOinclinic.

  • 标签: SUSTAINED CYCLOSPORINE A delivery mic-rosphere POSTERIOR
  • 简介:AIM:Toinvestigatetheefficacyofnon-buckledvitrectomywithclassicalendotamponadeagentsinthetreatmentofprimaryretinaldetachment(RD)complicatedbyinferiorbreaksandproliferativevitreoretinophathy(PVR).METHODS:Aretrospective,consecutiveandcaseseriesstudyof40patientswithinferiorbreakRDandPVR≥C1wasconducted.Allpatientsunderwentastandard3-port20-gaugeparsplanavitrectomy(PPV)withgasorsiliconeoiltamponadewithoutsupplementaryscleralbuckling.Thevitreousandallproliferativemembranewerecompletelyremoved,andretinectomywasperformedwhennecessary.Themeanfollow-upwas12.5months.Theprimaryandfinalanatomicsuccessrate,visualacuityandcomplicationswererecordedandanalyzed.RESULTS:Primaryanatomicsuccessratewasachievedin35of40eyes(87.5%)andthefinalanatomicsuccessratewas100%.ThemostcommoncauseofredetachmentwasrecurrentPVR.Thebest-correctedvisualacuity(BCVA)atfinalfollow-upwasimprovedin34eyes(85%),remainedstablein1eye(2.5%),andworsenedin5eyes(12.5%).Themeanvisualacuityatfinalfollow-upwasimprovedsignificantly(P=0.000).CONCLUSION:ThisretrospectivestudyprovidesevidencethatvitrectomywithoutscleralbucklingseemedtobeaneffectivetreatmentforinferiorbreakRDwithPVR.Withcompleteremovalofvitreousandproliferativemembranesandtimingofretinectomy,theinferiorbreakswhichcomplicatedwithPVRcouldbeclosedsuccessfullywithoutadditionalscleralbuckling.

  • 标签: RETINAL DETACHMENT INFERIOR RETINAL BREAK PROLIFERATIVE