简介：AIMTo调查vasoactive的角色在形式剥夺的肠的肽(贵宾)近视(频分多路复用).METHODSFDM被放在三组八只小鸡创造一半透明在他们的右眼睛上更弥漫。Intravitreal注射盐并且贵宾一天被使用一次进组的堵塞眼睛2和3分别地。视网膜镜检法和轴的长度(AL)大小在第一和8th天更弥漫穿。在三个组的右眼睛和白天8上的第一个组的左眼睛的VIP受体和ZENK蛋白质的视网膜mRNA层次用在权利的中部的最后的折射(D)看的.RESULTSThe是的实时聚合酶链反应(PCR)被决定-13.75(-16.00,-12.00),-11.50(-12.50,-7.50),和-1.50(在组的-4.75,-0.75)1，2，和3，分别地(P<0.001)。在右眼睛的中部的AL(公里)是10.65(10.00，11.10)，9.90(9.70，10.00)，并且9.20(9.15，9.25)在组1，2，和3，分别地(P<0.001)。为VIP2受体的中部的三角洲三角洲周期阀值(CT)价值是1.07(0.82，1.43)，1.22(0.98，1.65)，0.29(0.22，0.45)在组的右眼睛1，2，和3，和1.18(0.90，1.37)在组1的左眼睛，分别地(P=0.001)。为ZENK蛋白质的中部的三角洲三角洲CT价值是1.07(0.63，5.03)，3.55(2.20，5.55)，在组的右眼睛无法发现1，2，和3和1.89(0.21，4.73)在组1的左眼睛，(P=0.001)分别地，.CONCLUSIONVIP在频分多路复用的发展有潜在的禁止的效果。

简介：AIM:Toevaluatethelongtermclinicalresultsofmechanicalno-alcohol-assistedlaserepithelialkeratomileusis(LASEK)versusstandardphotorefractivekeratectomy(PRK)forlow-moderatemyopia.METHODS:Twenty-fiveeyestreatedwithLASEKandtwenty-fiveeyestreatedwithPRKwereevaluatedwithameanfollow-updurationof60mo.Mechanicalseparationoftheepitheliumwasperformedwithbluntspatulaandwithoutapplicationofalcohol.LaserablationwasperformedwiththeMEL-70excimerlaser.Allpatientswereexamineddailyuntilepithelialclosure;at1,3,6,and12mo,andeveryyearsubsequently.Mainoutcomemeasureswereuncorrecteddistancevisualacuity(UDVA),correcteddistancevisualacuity(CDVA),manifestrefraction,haze,efficacyandsafetyindexes.RESULTS:Twenty-oneeyesand22eyescompletedfollow-upof60moinLASEKandPRKgrouprespectively.Manifestrefractionat60mofollow-upwas-0.01and0.26inLASEKandPRKgrouprespectively.IntheLASEKgroupmeanUDVAandmeanCDVAafter60mowere20/22and20/20respectively(P>0.01).InthePRKgroupmeanUDVAandmeanCDVAat60mofollow-upwere20/20and20/20after60mo(P>0.01).Theefficacyindexeswere0.87and0.95,andthesafetyindexeswere1.25and1.4respectivelyforLASEKgroupandPRKgroup.CONCLUSION:BothstandardPRKandno-alcoholLASEKoffersafeandeffectivecorrectionoflow-moderatemyopiainthelongtermwithoutanystatisticallysignificantdifferencebetweenthetwogroups.

简介：AIM:Toevaluatethepositiveeffectsofblue-violetlightfilteringlensesindelayingmyopiaandrelievingasthenopiainjuveniles.METHODS:Sixtyametropiajuveniles(agedrange,11-15y)wererandomizedintotwogroups:thetestgroup(30children,60eyes),wearingblue-violetlightfilteringlenses;andthecontrolgroup(30children,60eyes),wearingordinaryasphericallenses.Baselinerefractivepoweroftheaffectedeyesandaxiallengthofthetwogroupswasrecorded.After1-year,thepatientsunderwentcontrastsensitivity(glareandnon-glareunderbrightanddarkconditions),accommodation-relatedtesting,asthenopiaquestionnaireassessment,andadversereactionquestionnaireassessment.RESULTS:After1yofwearingthefilteringlenses,changesinrefractivepowerandaxiallengthwerenotsignificantlydifferentbetweenthetwogroups(P>0.05).Underbrightconditions,thecontrastsensitivitiesatlowandmediumfrequencygrating(visionanglesof6.3°,4.0°,and2.5°)withglareinthetestgroupweresignificantlyhigherthaninthecontrolgroup(P<0.05),whilethecontrastsensitivityatlow-frequencygrating(visionanglesof6.3°and4.0°)intheabsenceofglareinthetestgroupwashigherthaninthecontrolgroup(P<0.05).Underglareandnon-glaredarkconditions,thecontrastsensitivitiesofvariousfrequenciesinthetestgroupdidnotshowsignificantdifferencescomparedwiththoseinthecontrolgroup(P>0.05).Inthetestgroup,theamplitudeofaccommodation,accommodativelag,andaccommodativesensitivityofpatientswearingglassesfor6and12moweresignificantlyelevated(P<0.05),whiletheasthenopiagratingsweresignificantlydecreased(P<0.05).Nevertheless,inthecontrolgroup,theamplitudeofaccommodation,accommodativelag,andaccommodativesensitivityafter12mowerenotsignificantlyalteredcomparedwithbaseline(P>0.05),andtheasthenopiagratingwasnotsignificantlydecreased(P>0.05).Inaddition,afterwearingglassesfor6to12mo,theasthenopiagratingofpatientsinthetestgro

简介：AIM:TocomprehensivelyevaluatethepotentialassociationofCOL1A1polymorphismswithhighmyopiabyasystematicreviewandMeta-analysis.METHODS:AllassociationstudiesonCOL1A1andhighmyopiareporteduptoJune10,2014inPubMed,Embase,WebofScience,andtheChineseBiomedicalDatabasewereretrieved.Oddsratios(ORs)and95%confidenceintervals(95%CIs)wereanalyzedforsinglenucleotidepolymorphisms(SNPs)usingfixed-andrandom-effectsmodelsaccordingtobetween-studyheterogeneity.PublicationbiasanalyseswereconductedbyEgger’stest.RESULTS:Atotaloffourstudiesfromreportedpaperswereincludedinthisanalysis.TheMeta-analysesforCOL1A1rs2075555,composedof2304highmyopiapatientsand2272controls,failedtodetectanysignificantassociationwithhighmyopia.Atotalof971casesand649controlsweretestedforCOL1A1rs2269336.TheassociationofCOL1A1rs2269336withhighmyopiawasobservedinrecessivemodel(CCvsCG+GG,P=0.03)andinheterozygousmodel(CGvsGG,P=0.04),butnotinothermodels.CONCLUSION:ThisMeta-analysisshowsthatCOL1A1rs2269336(CCvsCG+GG)affectsindividualsusceptibilitytohighmyopia,whereasthereisnoassociationdetectedbetweenSNPsrs2075555andhighmyopia.Giventhelimitedsamplesize,furtherinvestigationsincludingmoreethnicgroupsarerequiredtovalidatetheassociation.

简介：AIMTo在situkeratomileusis(FS-LASIK)在femtosecond激光以后比较视觉质量，在之间同轴地角膜的轻反射(CSCLR)组和常规脱离视觉(LOS)衬里的sightedgroup.METHODSIn总数，243只眼睛(122个病人)在CSCLR(视觉轴)上与centration被对待，238只眼睛(119个病人)在学生中心(LOS)上与centration对待。手术后的结果[未改正的视觉尖酸(UCVA)，最好的改正景色的视觉尖酸(BSCVA)]，安全索引，功效索引，折射结果，从视觉轴的脱离中心距离，角膜的高顺序的错误，主观不快瞪视和shadowing发生率，和对比在1点的敏感，3，并且6mo被测量，compared.RESULTSThe平均数年龄是27.77