简介:Semiparametrictransformationmodelsprovideaclassofflexiblemodelsforregressionanalysisoffailuretimedata.Severalauthorshavediscussedthemunderdifferentsituationswhencovariatesaretimeindependent(Chenetal.,2002;Chengetal.,1995;Fineetal.,1998).Inthispaper,weconsiderfittingthesemodelstoright-censoreddatawhencovariatesaretime-dependentlongitudinalvariablesand,furthermore,maysuffermeasurementerrors.Forestimation,weinvestigatethemaximumlikelihoodapproach,andanEMalgorithmisdeveloped.Simulationresultsshowthattheproposedmethodisappropriateforpracticalapplication,andanillustrativeexampleisprovided.