简介:Auniqueapproachforpermeationfillingofnonpermeableinertialconfinementfusiontargetcapsuleswithdeuterium-tritium(DT)ispresented.Thisprocessusesapermeablecapsulecoupledintothefinaltargetcapsulewitha0.03-mm-diameterfilltube.Leakfreepermeationfillingofglow-dischargepolymerization(GDP)targetsusingthismethodhavebeensuccessfullydemonstrated,aswellasicelayeringofthetarget,yieldinganinnericesurfaceroughnessof1-μmrms(rootmeansquare).Finally,themeasuredDTice-thicknessprofileforthisexperimentwasusedtovalidateathermalmodel'spredictionofthesamethicknessprofile.
简介:Theclosephotogrammetric3-Dcoordinatemeasurementisanewmeasuringtechnologyinthefieldsofthecoordinatemeasurementmachine(CMM)inrecentyears.Inthismethod,weusuallyplacesometargetsonthemeasuredobjectandtakeimageoftargetstodeterminetheobjectcoordinate.Thesubpixellocationoftargetimageplaysanimportantroleinhighaccuracy3-Dcoordinatemeasuringprocedure.Inthispaper,somesubpixellocationmethodsarereviewedandsomefactorswhichaffectlocationprecisionareanalyzed.Thenweproposebilinearinterpolationcentroidalgorithm.Theexperimentshaveshownthisalgorithmcanimproveaccuracyoftargetcentroidbyincreasingavailablepixels.
简介:Theimprovedlaser-to-pedestalcontrastratioenabledbycurrenthigh-powerlaserpulsecleaningtechniquesallowsthefinefeaturesofthetargetsurvivebeforethemainlaserpulsearrives.Weproposetointroducethenano-fabricationtechnologiesintolaser–plasmainteractiontoexplorethenoveleffectsofmicro-structures.Wefoundoutthatnotonlylaser-drivenparticlesourcesbutalsothelaserpulseitselfcanbemanipulatedbyspecificallydesignedmicro-cylinderand-tubetargets,respectively.Theproposalwassupportedbyfull-3Dparticle-in-cellsimulationsandsuccessfulproofof-principleexperimentsforthefirsttime.Webelievethiswouldopenawaytomanipulaterelativisticlaser–plasmainteractionatthemicro-sizelevel.
简介:BaliActionPlanprovisionsacknowledgethefactthatdevelopingcountriesarealreadymakingeffortstoreduceemissionsandmovetowardsalowcarbonpathway.TheCopenhagenAccordmentions"Nationallyappropriatemitigationactionsseekinginternationalsupportwillberecordedinaregistryalongwithrelevanttechnology,financeandcapacitybuildingsupport.Thephrase"measurable,reportableandverifiable"wascriticaltotheagreement,andthewayinwhichtheconceptofMRVisreflectedinthepost-2012agreementwillhavesignificantimplicationsfortheeffectivenessofthatagreementforstakeholdersinbothdevelopinganddevelopedcountries.Itisworthlookingforcurrentexamplesofdevelopingcountryprogramsthatcanbemeasured,reportedandverifiedandexamininghowcountriesthemselvescurrentlyundertakemitigationpoliciesandmeasures.ManyofChina’sdomesticpolicieshavebeenineffectforseveralyearsandthusprovideempiricalevidenceforhowsuchprogramscanworkontheground.ThispaperwillhighlighthowMRViscurrentlyapplieddomesticallyinChinaandwillnotmakeanyspecificproposalsfornegotiators;itonlyseekstoinforminternationaldiscussiononhowMRVmightbeappliedinpractice,andthereforewhatprovisionsmightberequiredinaUNFCCCclimateagreement.
简介:
简介:ThepresentpaperanalyzeshistoricallytherelationshipbetweencarbonemissionandeconomicdevelopmentbydifferentstagesthroughadoptingelasticdecouplingmethodsandTapioevaluationcriteriaalongwithacomparisonwiththenationalFiveYearPlans.TheanalysisshowsthattheinfluencingfactorstotherelationshipbetweencarbonemissionandeconomyinChinaaredifferent,andeconomicdevelopmentandcarbonemissionhavelessconnectionintherecent30yearsofreformandopening-upinChina.Itisadifficulttasktorealizethepromisethatwewillreducecarbonemissionby40%-50%in2020basedonthedatafromhistoricalexperienceanddifferentexpectationsforeconomicdevelopmentfromeconomists.Throughconstructingthecalcula-tionmodelofcarbonemissionintensitygapaccordingtodifferentdevelopmentscenarios,theanalysisshowsthateconomicgrowth,infrastructureinvestmentandfurtherdevelopmentofindustrial-izationarethemaindriverstotheincreaseofcarbonemission,technologicalprogress,andparticularly,thereductionofenergyconsumptionistheprimarymeanstoreducecarbonemissioninChina.Itisimperativetotransformtheeconomicgrowthpattern,anditisagrandtasktoperformandthereisalongwaytogoforChinatomaintaineconomicgrowthandreducecarbonintensity.
简介:TanshinoneIIAisapharmacologicallyactivecompoundisolatedfromDanshen(Salviamiltiorrhiza),atraditionalChineseherbalmedicineforthemanagementofcardiacdiseasesandotherdisorders.Butitsunderlyingmolecularmechanismsofactionarestillunclear.ThepresentinvestigationutilizedadataminingapproachbasedonnetworkpharmacologytouncoverthepotentialproteintargetsofTanshinoneIIA.Networkpharmacology,anintegratedmultidisciplinarystudy,incorporatessystemsbiology,networkanalysis,connectivity,redundancy,andpleiotropy,providingpowerfulnewtoolsandinsightsintoelucidatingthefinedetailsofdrug-targetinteractions.Inthepresentstudy,twoseparatedrug-targetnetworksforTanshinoneIIAwereconstructedusingtheAgilentLiteratureSearch(ALS)andSTITCH(searchtoolforinteractionsofchemicals)methods.AnalysisoftheALS-constructednetworkrevealedatargetnetworkwithascale-freetopologyandfivetopnodes(proteintargets)correspondingtoFos,Jun,Src,phosphatidylinositol-4,5-bisphosphate3-kinase,catalyticsubunitalpha(PIK3CA),andmitogen-activatedproteinkinasekinase1(MAP2K1),whereasanalysisoftheSTITCH-constructednetworkrevealedthreetopnodescorrespondingtocytochromeP4503A4(CYP3A4),cytochromeP450A1(CYP1A1),andnuclearfactorkappaB1(NFκB1).Thediscrepancieswereprobablyduetothedifferencesinthedivergentcomputerminingtoolsanddatabasesemployedbythetwomethods.However,itisconceivablethatalleightproteinsmediateimportantbiologicalfunctionsofTanshinoneIIA,contributingtoitsoveralldrug-targetnetwork.Inconclusion,thecurrentresultsmayassistindevelopingacomprehensiveunderstandingofthemolecularmechanismsandsignalingpathwaysofinasimple,compact,andvisualmanner.
简介:Forreal-timejammingsignalgenerationindeceivinginversesyntheticapertureradar(ISAR),thetargetcharacteristicsmodulationisalwaysprocessedintheexpensivefieldprogrammablegatearray(FPGA).Duetothelargecomputationalcomplexityofthetraditionalmodulatingoperation,thesizeandstructureofsimulatedfalse-targetarelimited.Withregardtotheprincipleofdechirpinginrangecompressionoflinearfrequencymodulated(LFM)radar,anovelalgorithmnamed'inversedechirping'isproposedfortargetcharacteristicsmodulation.ThisalgorithmonlyneedsonecomplexmultiplierintheFPGAtogeneratethejammingsignalwhentheradarsignalisintercepted,whichcanbeobtainedbymultiplicationofradarsignalsamplingsandtheequivalentdechirpedtargetechointhetimedomain.Asthecomplexsynthesisofdechirpedtargetechocanberealizedbycheapdigitalsignalprocessor(DSP)withintheinterpulsetime,theoverallcostofthejammingequipmentwillbereducedandthefalse-targetsizewillnotbelimitedbythescaleofFPGA.Numericalsimulationsareperformedtoverifythecorrectnessandeffectivenessoftheproposedalgorithm.
简介:ThedefiningneuropathologicalfeatureofParkinson’sdisease(PD)isthelossofnigrostriataldopaminergic(DA)projections.Thisresultsinabiochemicalreductionofstriataldopaminelevelsandmovementdisorders,suchasatremoratrest,rigidityofthelimbs,bradykinesia,andposturalinstability(Kimetal.,2011;Kimetal.,2012;BurkeandO’Malley,2013;Leemetal.,2014;Nametal.,2014).BecausetheetiologyofPDisnotfullyunderstood,itcannotguidethedevelopmentofknowledge-basedtargetedtherapeutics.
简介:Spacecraftsciencemissionstoplanetsorasteroidshavehistoricallyvisitedonlyoneorseveralcelestialbodiespermission.Theresearchgoalofthispaperistocreateatrajectorydesignalgorithmthatgeneratestrajectoryallowingaspacecrafttovisitasignificantnumberofasteroidsduringasinglemission.Fortheproblemofglobaltrajectoryoptimization,evenwithrecentadvancesinlow-thrusttrajectoryoptimization,afullenumerationofthisproblemisnotpossible.Thisworkpresentsanalgorith...
简介:Parkinson’sdisease(PD)isanage-relatedneurodegenerativedisordercharacterizedbytypicalmotorsignsandsymptomsthatareduetodopamine(DA)depletioninthebasalganglia.ThetreatmentofPDissymptomatic,andaimsatreplacingthelostDAinputusingeitherL-DOPAorDAagonists.ThecausesofPDareunknownin
简介:Inthehourstoweeksfollowingtraumaticspinalcordinjuries(SCI),biochemicalprocessesareinitiatedthatfurtherdamagethetissuewithinandsurroundingtheinitialinjurysite:aprocesstermedsecondaryinjury.Acrolein,ahighlyreactiveunsaturatedaldehyde,hasbeenshowntoplayamajorroleinthesecondaryinjurybycontributingsignificantlytobothmotorandsensorydeficits.Inparticular,effortshavebeenmadetoelucidatethemechanismsofacrolein-mediateddamageatthecellularlevelandtheresultingparalysisandneuropathicpain.Inthisreview,wewillhighlighttherecentdevelopmentsintheunderstandingofthemechanismsofacroleininmotorandsensorydysfunctioninanimalmodelsofSCI.Wewillalsodiscussthetherapeuticbenefitsofusingacroleinscavengerstoattenuateacrolein-mediatedneuronaldamagefollowingSCI.
简介:Inordertoimprovetheperformanceoflinespectrumdetection,accordingtothefeaturethattheunderwatertargetradiatednoisecontainingstablelinespectrum,thedifferencesofthephasedifferencebetweenlinespectrumandbackgroundnoise,aweightedlinespectrumdetectionalgorithmbasedonthephasevarianceisproposedinfrequencydomain.Afterphasedifferencealignment,thephasevarianceoflinespectrumandthephaseofbackgroundnoise,respectively,aresmallandbiginfrequencydomain,thismethodutilizestheweightedstatisticalalgorithmtocumulatethefrequencyspectrumbasedonthephasevariance,whichcanrestrainthebackgroundnoisedisturbance,andenhancethesignaltonoiseratio(SNR).Thetheoryanalysisandexperimentalresultsbothverifythattheproposedmethodcanwellenhancetheenergyoflinespectrum,restraintheenergyofbackgroundnoise,andhavebetterdetectionperformanceunderlowerSNR.
简介:Theaccuratedetectionofcooperativetargetsplaysakeyandfoundationalroleinunmannedaerialvehicle(UAV)landingautonomously.Thestandardmethodbasedonfixedthresholdistoosusceptibletobothilluminationvariationsandinterference.Toovercomeissuesabove,arobustdetectionalgorithmwithtripleconstraintsforcooperativetargetsbasedonspectralresidual(TCSR)isproposed.Firstly,bydesigninganasymmetriccooperativetarget,whichcomprisesredbackground,greenHandtriangletarget,thecapturedoriginalimageisconvertedintoaLabcolorspace,whosesaliencymapisyieldedbyconstructingthespectralresidual.Then,thetripleconstraintsaredevelopedaccordingtothepriorknowledgeofthecooperativetarget.Finally,thesalientregioninsaliencymapisconsideredasthecooperativetarget,anditmeetsthetripleconstraints.ExperimentalresultsincomplexenvironmentsshowthattheproposedTCSRoutperformsthestandardmethodsinhigherdetectionaccuracyandlowerfalsealarmrate.