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简介：Agluten-freedietiscurrentlytheonlyeffectivemeansoftreatingindividualswithceliacdisease.Suchadietenablesceliacpatientstocontroltheirsymptomsandavoidvariouscomplicationsassociatedwiththiscondition.However,whilethequalityofgluten-freefoodshassignificantlyimprovedduringrecentdecades,maintenanceofagluten-freedietdoesnotnecessarilyensureadequatenutritionalintake.Becauseoatsareanimportantsourceofproteins,lipids,vitamins,minerals,andfibre,theirinclusioninagluten-freedietmightimprovethenutritionalstatusofaceliacpatient.AlthoughoatsareincludedinthelistofglutenfreeingredientsspecifiedinEuropeanregulations,theirsafetywhenconsumedbyceliacpatientsremainsdebatable.Somestudiesclaimthatpureoatsaresafeformostceliacpeople,andcontaminationwithothercerealsourcesisthemainproblemfacingpeoplewiththisdisease.However,itisnecessarytoconsiderthatoatsincludemanyvarieties,containingvariousaminoacidsequencesandshowingdifferentimmunoreactivitiesassociatedwithtoxicprolamins.Asaresult,severalstudieshaveshownthattheimmunogenicityofoatsvariesdependingonthecultivarconsumed.Thus,itisessentialtothoroughlystudythevarietyofoatsusedinafoodingredientbeforeincludingitinagluten-freediet.

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简介：Generally,ROSareregardedashostdefensemoleculesthatarereleasedbyneutrophilstodestroyexogenouspathogenssuchasbacteriaandtoactassecondarymessengersinsignaltransduction.However,increasedproductionofROSisalsoinvolvedininducingpathophysiologicalchangessuchasapoptosis,cellcycledisruption,andnecrosis.Forthisreason,inductionofROS-mediateddamageincancercellsbypharmacologicalagentsthateitherpromoteROSgenerationordisablethecellularantioxidantsystemisconsideredapotentialtherapeuticstrategyforpreferentiallykillingcancercells[1].

简介：Inthispaper,IwillbrieflyanalyzetheroleofmassmediainthedevelopmentofTibettourism.ThroughsomeexamplesandsometheoreticalanalysiswewillmainlydiscusstheproblemsandtheprospectsofTibettourismmedia.IsincerelyhopethisthesiswillprovidesomegoodsuggestionsandviewstothedevelopingofTibettourism.

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简介：Renewableenergyisclearlyaveryimportanttopicnowadays.Theriskandthedamagethatcouldbecausedbyconventionalenergyresourcescannotbehidden.Thereisanenormousneedthatpeoplestartformulatingabetterattitudetowardsrenewableenergyandchangetheirconsumptionbehaviour.Otherwise,thefutureofenvironmentandthecominggenerationsaredefiantlynotgoingtobepromising.Thispaperdiscussestheimportanceofsustainableenergyandhowtheenergyrelatedbehaviouriscreated.Itpresentsaframeworktoinfluencethecurrentbehaviourandpushittobemoregreenoriented.Itisalsoimportanttoknowtillwhatlimitaregovernmentsresponsibleinthischange,andwhatarethetoolsthattheyhavetopushtowardsgreendirection.

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简介：Inthispaper,weanalyzedtheOneFoundationsreliefandreconstructionactivitiesaftertheYaanearthquake.TheanalysisshowsthattheparticipationofNGOsindisasterreliefactivitieshasundergonedifferentstages.IntheJiujiangearthquake,NGOsparticipationwasintherudimentarystage.IntheWenchuanearthquake,theybecameoneoftheactiveparticipants.IntheYaanearthquake,theyplayedanactiverolethroughacooperationmechanism.ThatmeansNGOshavehadthecapabilityofresourcemobilizationandcooperationwiththemwillimprovedisastermanagementcapacities,especiallyinthenationalsignificantseismicmonitoringandprotectionregions.

简介：Weinvestigatethetargetandintensitydependenceofplateauinhigh-orderabovethresholdionization(HATI)bysimulatingthetwo-dimensional(2D)momentumdistributionsandtheenergyspectraofphotoelectronsinHATIofraregasatomsthroughusingthequantitativerescatteringmodel.Thesimulatedresultsarecomparedwiththeexistingexperimentalmeasurements.ItisfoundthattheslopeoftheplateauintheHATIphotoelectronenergyspectrumhighlydependsonthestructureofelasticscatteringdifferentialcrosssection(DCS)oflaser-inducedreturningelectronwithitsparention.Theinvestigationsofthelong-andshort-rangepotentialeffectsintheDCSsrevealthattheshort-rangepotential,whichreflectsthestructureofthetarget,playsanessentialroleingeneratingtheHATIphotoelectronspectra.

简介：Definitiveconclusionsconcerningtheimpactofexerciseinterventionsonchildren'smentalfunctioningaredifficulttoascertainbecauseofproceduraldifferencesamongstudies.Anarrativereviewofstudieswasconductedtoevaluatetheroleoftwotypesofexerciseinterventionsonchildren'scognition.Acuteandchronicexerciseinterventionswereclassifiedasquantitativeorqualitativeonthebasisofmanipulationsoftaskcomplexityand,byinference,mentalengagement.Bothtypesofinterventionsenhanceaspectsofchildren'scognition;however,theireffectsonmetacognitiveprocessesareunknown.Theroleofmetacognitiveprocessesandtheirregulationofchildren'sbehaviorandacademicperformancearehighlighted.

简介：Accumulatingevidencefromepidemiologicalandexperimentalstudiesindicatethatobesity,anditsrelatedmetabolicconsequencesofinsulinresistanceandtype2diabetes,areassociatedwithacceleratedcognitivedecline(Yatesetal.,2012).Theetiologyofneurodegenerationinobesityisundoubtedlycomplex,withvascular,metabolic,inflammatory,andstructuralchangesalllikelytoplayarole(Yatesetal.,

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简介：Survivalratesformetastaticlungcancer,includingnon-smallcelllungcancer(NSCLC)andsmallcelllungcancer(SCLC),arepoorwith5-yearsurvivalsoflessthan5%.Theimmunesystemhasanintricateandcomplexrelationshipwithtumorigenesis;agroundswellofresearchontheimmunesystemisleadingtogreaterunderstandingofhowcancerprogressesandpresentingnewwaystohaltdiseaseprogress.Duetotheextraordinarypoweroftheimmunesystem—withitscapacityformemory,exquisitespecificityandcentralanduniversalroleinhumanbiology—immunotherapyhasthepotentialtoachievecomplete,long-lastingremissionsandcures,withfewsideeffectsforanycancerpatient,regardlessofcancertype.Asaresult,arangeofcancertherapiesareunderdevelopmentthatworkbyturningourownimmunecellsagainsttumors.Howeverdeeperunderstandingofthecomplexityofimmunomodulationbytumorsiskeytothedevelopmentofeffectiveimmunotherapies,especiallyinlungcancer.

简介：AIM:Todeterminewhetherretinalcirculatorychangesplayaroleinthepathogenesisofmaculardisordersinpatientswhoareotherwisehealthy.METHODS:Patientswithmaculardisordersthatrequiredangiographicimagingwereincludedinthisprospectivecaseseries.Afteracompleteocularexam,fluoresceinangiographywasperformedusingastandardizedtechniqueontheHRA-II(HeidelbergEngineering,Heidelberg,Germany)withspecialfocusontheposteriorpole.Onlypatientswithgoodqualityimageswereincludedintheanalysis.Circulatoryparametersrecordedincludedthearm-choroidtime,choroid-retinalartery,andfinallytheretinalartery-veintime.Zonalasymmetry(betweentheupperandlowerzonesdividedbyalinepassingthroughthecentreofthefovea)intransittimes,ifanywasalsonoted.Appropriatestatisticalanalysiswasdone.Circulationtimeswerecomparedwithagematchedhistoricalcontrols.Changesinretinaldyetransittimesrelativetohistoricalagematchedcontrols,ifany,werenotedandcomparedbetweenvariousdisorders.RESULTS:Atotalof156eyesof156patients(120males)wereincludedinthestudy.Meanage:49.14±14.93y.Maculardisordersstudiedwereagerelateddegeneration,polypoidalvasculopathy,centralserouschorioretinopathy(CSCR)andparafovealtelangiectasia.DelayedcirculationtimewasnotedinCSCRpatientsonly.CONCLUSION:CSCRpatientsappeartohavedelayedarterialfilling,retinalcirculatorydisturbancesdonotseemtocontributetothepathogenesisofothermaculardisorders.

简介：<正>Aftermorethan30yearsofreformandopeningup,significantchangeshavetakenplaceinChina’seconomictieswiththerestoftheworld.InordertobringChina’sopeningupdrivetoanewlevelinlinewiththelatestdevelopmentstoeconomicglobalization,weneedtotakemoreproactivestepsandopenupfurthertotherestof

简介：Transforminggrowthfactor-β(TGF-β)isakeyfactorincancerdevelopmentandprogression.TGF-βcansuppresstumorigenesisbyinhibitingcellcycleprogressionandstimulatingapoptosisinearlystagesofcancerprogression.However,TGF-βcanmodulatecancer-relatedprocesses,suchascellinvasion,distantmetastasis,andmicroenvironmentmodificationthatmaybeusedbycancercellstotheiradvantageinlatestages.Correspondingmechanismsincludeangiogenesispromotion,anti-tumorimmunitysuppression,andepithelial-to-mesenchymaltransition(EMT)induction.ThecorrelationbetweenTGF-βexpressionandcancerprognosishasalsobeenextensivelyinvestigated.ResultssuggestthatTGF-βpathwaycanbetargetedtotreatcancer;assuch,thefeasibilityofthistreatmentisinvestigatedinclinicaltrials.

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