简介:AbstractPhenuiviridae, a member of the Bunyavirales order, can lead to significant human morbidity and mortality. Various phenuiviruses target specific cellular proteins and have strategies to counteract the effects of type I interferon (IFN). Previous studies have shown that phenuiviruses infection inhibits the synthesis of type I IFNs, and viral nonstructural proteins (NSs) had been further identified as an IFN antagonist. This study found that the NSs proteins of Dabie bandavirus (DBV), Sandfly fever Sicilian virus (SFSV), and Uukuniemi virus (UUKV) can inhibit Sendai virus-induced activation of IFN-β promoter and phosphorylation of IFN regulatory factor 3 (IRF3). Moreover, detailed analysis revealed that the phenuivirus NSs protein could directly interact with retinoic acid inducible gene-I (RIG-I) and degrade it via a proteasome-dependent pathway. In short, this study demonstrate a novel mechanism of phenuiviruses to resist host antiviral immunity, which may help understand these pathogens and suggest novel therapeutic approaches.
简介:摘要随着社会人口老龄化趋势不断加剧,老年性聋的发病率逐年增加,严重影响着老年人生活质量。老年性聋的发病原因及机制复杂,也缺乏规范有效的预防及治疗手段。本文就老年性聋干预措施最新研究进展从药物治疗、验配助听器、人工耳蜗植入以及基因治疗等方面做一系统综述。
简介:摘要 聋生英语学习是学习中的一个难点,本文从环境,聋生和教师三个方面分析了聋生英语学习薄弱的原因,并提出了一些相应的建议:1. 营造学习氛围;2. 树立学习信心;3. 激发学习兴趣;4. 传授学习方法; 5. 提高课堂效率;6. 提高教师水平。