简介：无

简介：Theauthorsofthepresentpapertreated50casesofmigrainebyscalpacupuncturepluselectro-combstimulationfrom1995to1999andachievedsatisfactorytherapeuticeffects.Itisreportedasfollows.

简介：Monoclonal(mAb)成功地被用于长期的疾病的治疗，例如癌症，发炎和有免疫力的疾病。与在抗体工程的技术进展，当有减少的immunogenicity的高亲密关系治疗学在聚光灯下面变得，小重组体抗体的开发碎裂。设计重组体抗体碎片的一种流行格式是单个链的改正变量(scFv)分子，父母抗体的VH和VL区域被一个多肽连接器一起在连接。scFv碎片保留目标特性和未经触动的抗体，和罐头的抗原绑定亲密关系被在房间从单个cDNA表示VH和VL区域的宫外的联盟者遗传上在大数量设计并且生产。由于它的更小的尺寸，scFv分子表演在肿瘤穿入改进了pharmacokinetics并且被主人免疫系统更好容忍。

简介：目的:观察针灸治疗萎缩性胃炎的临床疗效.方法:取中脘、足三里穴,用阳中隐阴法治疗38例萎缩性胃炎患者,评定疗效,并与药物组进行疗效比较.结果:针灸组与药物组临床综合疗效比较,有效率分别为81.6%和84.2%,两者统计学处理P＞0.05,临床无显著性差异.结论:表明针灸治疗萎缩性胃炎具有与药物相同的治疗效果.

简介：

简介：

简介：

简介：目的：观察经皮穴位电刺激对粘连前期肩关节周围炎的治疗作用。方法：采用大样本、多中心、随机化等循证医学研究方法，对163例粘连前期肩关节周围炎患者分别进行经皮穴位电刺激治疗和电针治疗，观察经皮穴位电刺激对粘连前期肩周炎的治疗作用及与电针治疗的效应比较。结果与结论：经皮穴位电刺激对粘连前期肩周炎的总有效率达到96．59％，与电针比较无明显差异；该疗法不仅具有明显的止痛效应，对肩关节活动障碍也有明显的改善作用。经皮穴位电刺激为治疗肩周炎有效、简便的疗法。

简介：在男孩，中央早熟的发身(CPP)是以前垂体促性腺激素分泌物驾驶的第二等的性别特征的外观9年的年龄。在最后年里，在CPP的处理的相关改进被完成了。因为CPP在男孩是稀罕的，这个问题上的报纸的多数集中于女孩并且不关于结束结果和安全探讨男病人的特定的特征。在现在的纸，有在男人的GnRH类似物的CPP管理的最近的进展被总结。在未经治疗、对待的病人的结束结果被最近出版的文学的分析也在男人在CPP的治疗上考察。可得到的数据显示没有重要不利短期、长期的效果，有GnRH类似物的那治疗能改进最后的高度进目标高度的范围，但是病人的更大的系列的更长的后续是仍然要求了得出权威的结论。

简介：Objective:　Toanalyzethecausesofdistalfemoralnonunionanddelayedunionandassesstheoutcomeofthecorrespondingtreatment,retrogradeintramedullaryinterlockingnail(RIIN).　　Methods:　FromJune1995toDecember1998,15patients(9malesand6females)withdistalfemoralnonunionanddelayedunionweretreatedwithRIIN.Theaverageageofthepatientswas34.5years(23-46years).Bonegraftingwasperformedin10patients,closedreamingwasdoneintheother5patients.Correctionosteotomywasperformedin2patients,andintra-articularreleaseofkneeadhesionin11patients.X-rayexaminationandkneesocietyclinicalratingsystem(KSS)wereusedtoevaluatetheresults.　　Results:　Allfractureswerefollowedupforatleast9monthswithaveragefollow-updurationof14.5months(9-33months).Solidunionwasdocumentedinallpatientsat6.4monthsonaverage.Therewerenoinfectionsormalunionsinthisseries.Basedonthefinalfollow-updata,acceptablefunctionalrangeofmotion(ROM)ofover90°wasachievedinmostpatients.TheaverageROMwas93.5°withsignificantimprovementof28°(42.7%,P＜0.05)comparedwiththepreoperativeROM.Theaveragekneescorewas96.ExcellentROMemergedin13patients.Thekneefunctionscorewas90.5onaverage.　　Conclusions:　Themaincausesofdistalfemoralnonunionanddelayedunionareimproperindicationsandimproperuseoftheimplants.RIINisaneffectivealternativefortreatmentofdistalfemoralnonunionanddelayedunionbecauseitcanprovideastableandreliablefixationwhichisbeneficialforearlyfunctionalexerciseofknee.Bonegrafting,closedreamingandintra-articularreleaseofkneeadhesionshouldbeconsideredinordertoenhancethebonehealingandimproveROMandthekneefunction.

简介：AbstractImportance:Neuroblastoma is the most common extracranial malignant solid tumor in children. Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed, treated, and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months; 80.8% of the patients were younger than 5 years of age. Notably, 243 patients (23.3%) were classified as low-risk, 249 patients (23.9%) were classified as intermediate-risk, and 549 (52.7%) were classified as high-risk. Furthermore, 956 patients underwent surgical resections; 986 (94.7%) patients received chemotherapy; and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation. The 5-year event-free survival (EFS) rate was 91.3% and 5-year overall survival (OS) rate was 97.5% in low-risk group; in the intermediate-risk group, these rates were 85.1% and 96.7%, respectively, while they were 37.7% and 48.9% in the high-risk group (P < 0.001 for both). The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014 (P < 0.001). In total, 278 patients (26.7%) exhibited tumor relapse or progression; the median interval until relapse or progression was 14 months. Of the 233 patients who died, 83% died of relapse or progression of neuroblastoma and 4.3% died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients, compared with low-and intermediate-risk patients. Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma. Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma.

简介：

简介：“开火的复合真空”和熄灭的水技术在LiFePO4的合成被介绍阴极粉末。样品被加热在真空石英试管封上的预先分解的先锋混合物准备，走水路在sintering温度熄灭跟随。结果显示使用“快熄灭”的处理能成功控制最后的产品的谷物尺寸的增生并且改进它活跃材料的利用比率。样品由这种技术综合了有高可逆的分泌物特定的能力和好周期的电气化学的性能。

简介：目的：观察采用具有通经活络作用的推拿、针刺、穴位注射三种方法综合治疗小儿臂丛神经损伤的临床效果。方法：用一指禅推法、拿法、揉法等手法放松患侧颈项及上肢部，点按颈夹脊、肩井、扶突、极泉、肩髑、曲池等穴位；针刺采用毫针刺颈夹脊、天窗、扶突、极泉、曲池、外关、阳池、合谷等主穴及相应的配穴，平补平泻；穴位注射用曲力甲钴胺注射液，选取肩髑、肩髂、曲池、手三里、外关、阳池、合谷等分别注射，隔日一次。结果：35例患儿中，痊愈22例，显效9例，好转4例。结论：”通络三法”治疗小儿臂丛神经损伤具有临床效果好，疗程短的优点。

简介：AbstractMilitary training is intense, difficult and often dangerous, so all kinds of injuries or diseases frequently occur during training. Most of the previous studies and reviews on military training-related injuries focused on musculoskeletal system, whereas there are no reviews of abdominal injuries and diseases. Although the incidence of military training-related abdominal injuries and diseases is relatively low, the patients’ condition is often critical especially in the presence of abdominal organ injury, leading to multi-organ dysfunction syndrome and even death. This paper elaborates on common types of military training-related abdominal injuries and diseases as well as the prevention and treatment measures, which provides some basis for scientific and reasonable training and improvement of medical security.

简介：AbstractTreatment of multiple myeloma (MM) has advanced dramatically in the past two decades. However, under the conditions of the COVID-19 pandemic, treatment strategies have been modified accordingly. Numerous novel agents, updated trials, and major advances in myeloma have been reported in the American Society of Hematology 2020 annual meeting, either for transplant-eligible or ineligible patients. Hot topics such as the significance of autologous stem cell transplantation (ASCT), development of novel agents, and chimeric antigen receptor-T (CAR-T) cells have been widely discussed. The triplet regimen bortezomib, lenalidomide, and dexamethasone (VRd) is recommended as the standard first-line treatment, and the addition of a fourth drug improves efficacy and survival. The value of ASCT remains undoubtful, even in the era of quadruplet induction. Dual-drug maintenance, including proteasome inhibitors and immunomodulatory drugs, overcomes unfavorable outcomes in high-risk patients. For relapsed/refractory myeloma (RRMM) patients, novel agents such as selinexor and venetoclax are superior. CAR-T cells and other cell-surface-targeted therapies also appear promising.

简介：AbstractPost-traumatic osteomyelitis (PTO) is a worldwide problem in the field of orthopaedic trauma. So far, there is no ideal treatment or consensus-based gold standard for its management. This paper reviews the representative literature focusing on PTO, mainly from the following four aspects: (1) the pathophysiological mechanism of PTO and the interaction mechanism between bacteria and the body, including fracture stress, different components of internal fixation devices, immune response, occurrence and development mechanisms of inflammation in PTO, as well as the occurrence and development mechanisms of PTO in skeletal system; (2) clinical classification, mainly the etiological classification, histological classification, anatomical classification and the newly proposed new classifications (a brief analysis of their scope and limitations); (3) imaging diagnosis, including non-invasive examination and invasive examination (this paper discusses their advantages and disadvantages respectively, and briefly compares the sensitivity and effectiveness of the current examinations); and (4) strategies, including antibiotic administration, surgical choices and other treatment programs. Based on the above-mentioned four aspects, we try to put forward some noteworthy sections, in order to make the existing opinions more specific.

简介：AbstractGastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the digestive system and are not sensitive to traditional chemotherapy. Therefore, historically, surgical resection was the only effective therapy. However, the emergence of tyrosine kinase inhibitors (TKIs) has revolutionized the treatment of GISTs, because they target c-Kit and PDGF receptor-α (PDGFRA), which are important in GIST development and progression. As research into c-Kit and PDGFRA continues, an increasing number of different TKIs are being used in the clinical setting. This review aims to discuss the current state of chemotherapy for the treatment of GISTs with different genotypes.

简介：Objective:　Toreportamethodandremotetherapeuticeffectofearlynervetranspositionintreatmentofobstetricalbrachialplexuspalsy.　　Methods:　FromMay1995toAugust1996,12patientswhohadnorecoveryofbiceps3monthsafterbirthweretreatedwithnervetransposition.Eighthadneuromaattheuppertrunkand4hadruptureoravulsionoftheuppertrunk.Mallettestwasusedtoevaluatetheresults.　　Results:　Thefollow-upof40-52monthsshowedthatexcellentandgoodrecoveryinfunctionswasfoundin75%ofthepatientsandtheexcellentrateofphrenicnerveandaccessorynervetranspositionwas83.3%and66.7%respectively.Acompleterecoveryinshoulderandelbowjointfunctionwasin3patientsandMalletⅣwasin6patients.　　Conclusions:　Satisfactoryoutcomecanbeobtainedbyusingearlynervetranspositionintreatingobstetricalbrachialplexus.Paralysis,obstetric;Peripheralnerves;Nervetransposition

简介：我学习的最近的阶段报导了单个代理人的活动poly(自动数据处理核糖)聚合酶(PARP)禁止者在分散并且在BRCA变异的前列腺癌症。在前列腺癌症，et基因重新整理和PTEN的损失的二最普通的基因改变，在现出症状之前的潜的模型被连接了到增加的敏感到PARP禁止者。新兴的证据也建议PARP1在调停起一个重要作用雄激素受体(AR)和et基因重新整理的transcriptional活动。在这篇文章，在为变形前列腺癌症作为一个新治疗范例开发PARP基于禁止者的治疗的现出症状之前的潜的工作和早阶段的临床的审判被考察。