简介：SHANDONG,abigindustrialandagriculturalprovincewithalargepopulation,hassummarizedaclearurbanizationconcept.TheprovinceunveiledonSeptember3,2014itsdevelopmentplan（2014-2030）foranewruralcommunityandnewruralarea.Asaresult,some14,ooovillages,ofapopulationofaround14million.

简介：Thisarticlefirsttracestheoriginoffourconcepts:InternationalPolitics(IP),InternationalRelations(IR),WorldPolitics(WP)andGlobalPolitics(GP)anddiscussesthesimilaritiesamongthesefourparadigms.Itthenanalysestheirapplicationbothathomeandabroad.Finally,itarguesforthedesirabilityofselectingtheconceptofIPinacademictraining,thusfacilitatingpracticalapplicationofconcepts.ItassertsthatthiswillnotonlyenhanceacademicdiscussionaboutIPamongdifferentChineseschoolsofthought,butalsohelpblazingnewideas.

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简介：肌肉损害在运动仍然是最普通的损害之一，还尽管有这，几乎没有怎么有效地描述或决定特定的肌肉损害的预后到也上的很少一致。肌肉分类的众多的途径并且药分级在最后世纪被使用了，但是在最后十年，历史性的途径的限制被认出了。作为后果，在过去的10年里，临床的研究组开始询问了历史性的途径并且重新考虑肌肉损害被分类并且描述的方法。用一条记事途径，这张手稿描述几次最近的尝试分类并且分级肌肉损害并且加亮每个系统的相对力量和软弱。当时每新分类和分级的系统有力量，几乎在那里不在全面的一个系统和基于的证据上仍然是很少一致。很少在分级的系统以内的当前识别的特征有关联到精确地决定预后。

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简介：国际组织具有很多种类，也具有着多种目的。这些各种各样的国际组织在国际社会存在的理由是什么呢?为了回答这个问题，首先要考虑特定的时期内有怎样的国际组织研究Paradigm(范式)。因为代表一个时期的国际组织研究范式对解决特定时期的国际问题起到了有效的职能，而且这种范式的存在和多样的国际组织的设立也有一定的联系。对于如此多样的国际组织的研究从很久以前就已经开始存在，但是事实上仅仅进行某一种国际组织范式研究，其理论无法提供总括性的、体系性的说明。

简介：很多人认为UPS的技术发展已到巅峰的阶段，艾默生网络能源有限公司凭借其技术雄厚的研发实力，以及多年引领行业发展带来的敏锐嗅觉，倾力开发出新一代高频化、数字化、纯在线双变换的智能UPS产品-Pamdigrn，为广大用户寻求更为理想的网络能源解决方案提供了新的可能。

简介：Combininglaw,computerscienceandfinaneeinunprecedentedways,＂smart＂contracthasthepotentialtoreshapeourunderstandingofcontractlaw.Basedonblockchaintechnology,a＂smart＂contractisacontractcapturedincode,whichautomaticallyperformstheobligationsthepartieshavecommittedtointheagreement.Byremovingtheneedfordirecthumaninvolvement,oncea＂smart＂contracthasbeendeployedontoatrustlesspublicledger（TPL）.

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简介：从大规模人的活动的增加的碳排出物贡献了全球气候变化，它导致了重要人的危机的增加。因此，作为碳，消退是公众好，应付气候变化也是一公众好；然而，它受不了许多免费骑手的刺激，导致commons的一个悲剧。从一个全身的观点克服这挑战，要求象全球、国家、地区性的层次上的工业，管理，和公民那样的所有部门从事低碳的开发和晴朗、有效的气候政策的实现。通过碳消退的理论探索和对低碳的系统的全身的描述，这份报纸为应付气候变化开发了一个控制论的框架，它为数据分析，为决定支持的元合成的工程，广泛的咨询的一条多中心的途径和各种各样的功能的目标成就模块由一个云平台组成。在这个基础上，由联合不可见的手和可见的手并且由在全球水平集成协商，在国家水平的合作和在本地水平的知识，一个multilevel决策模型被建议到地址建筑群气候变化问题。基于的创新途径能提供的这个控制论的范例珍贵照明到寻求应付气候的股东变化。

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简介：Laryngealsquamouscellcarcinoma(LSCC)remainsahighlymorbidandfataldisease.Historically,ithasbeenamodelexamplefororganpreservationandtreatmentstratificationparadigms.Unfortunately,survivalforLSCChasstagnatedoverthepastfewdecades.Astheeraofnext-generationsequencingandpersonalizedtreatmentforcancerapproaches,LSCCmaybeanidealdiseaseforconsiderationoffurthertreatmentstratificationandpersonalization.Here,wewilldiscusstheimportanthistoryofLSCCasamodelsystemfororganpreservation,uniqueandpotentiallytargetablegeneticsignaturesofLSCC,andmethodsforbringingstratified,personalizedtreatmentstrategiestothe21~(st)century.

简介：Precisionmedicineaimstoidentifytherightdrug,fortherightpatient,attherightdose,attherighttime,whichisparticularlyimportantincancertherapy.Problemssuchasthevariabilityoftreatmentresponseandresistancetomedicationhavebeenlongstandingchallengesinoncology,especiallyfordevelopmentofnewmedications.Solidtumors,unlikehematologicmalignanciesorbraintumors,areremarkablydiverseintheircellularoriginsanddevelopmentaltiming.Theabilityofnext-generationsequencing(NGS)toanalyzethecomprehensivelandscapeofgeneticalterationsbringspromisestodiseasesthathaveahighlycomplexandheterogeneousgeneticcompositionsuchascancer.HereweprovideanoverviewofhowNGSisabletofacilitateprecisionmedicineandchangetheparadigmofcancertherapy,especiallyforsolidtumors,throughtechnicaladvancements,moleculardiagnosis,responsemonitoringandclinicaltrials.

简介：AbstractThe gold standard of cancer diagnosis has long been based on histological characteristics. With the rapid advancement of genetic medicine, such standard algorithm of diagnostic approach is facing a challenge. The genetic findings have been changed from being a "supporting character" into the role of a "main character" . More and more disease diagnosis and classification has to be defined by genetic basis. In this article, we focus on the challenges in the field of pediatric oncology. We cited 2 scenarios where genetic information plays a pivotal role in identifying the underlying pathology. The first scenario is that same genetic mutation can lead to variable clinical phenotypes, this includes EWSR1-PATZ1 fusion related neoplasms; BCOR neoplasms; and GATA-2 deficiency related immunodeficiency and myelodysplastic syndrome. Another scenario is relatively more common that is the same clinical and histopathological phenotype with different underlying genotypes. The genotypes actually impact on the treatment response and outcome. We used medulloblastoma as an example. In fact, we can also find similar scenario in many pediatric cancers such as Ewing sarcoma, ependymoma, etc. The essence of this article is to remind clinicians of the rapid development in genetic medicine and it has been reshaping the landscape of the modern disease classification and therapeutic approach. In the near future, it may even lead to a paradigm shift in our disease diagnostic algorithm.

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简介：我学习的最近的阶段报导了单个代理人的活动poly(自动数据处理核糖)聚合酶(PARP)禁止者在分散并且在BRCA变异的前列腺癌症。在前列腺癌症，et基因重新整理和PTEN的损失的二最普通的基因改变，在现出症状之前的潜的模型被连接了到增加的敏感到PARP禁止者。新兴的证据也建议PARP1在调停起一个重要作用雄激素受体(AR)和et基因重新整理的transcriptional活动。在这篇文章，在为变形前列腺癌症作为一个新治疗范例开发PARP基于禁止者的治疗的现出症状之前的潜的工作和早阶段的临床的审判被考察。

简介：Nonceliacglutensensitivity(NCGS)isasyndromecharacterizedbyacohortofsymptomsrelatedtotheingestionofgluten-containingfoodinsubjectswhoarenotaffectedbyceliacdisease(CD)orwheatallergy.Thepossibilityofsystemicmanifestationsinthisconditionhasbeensuggestedbysomereports.Inmostcasestheyarecharacterizedbyvaguesymptomssuchas‘foggymind’,headache,fatigue,jointandmusclepain,legorarmnumbnessevenifmorespecificcomplaintshavebeendescribed.NCGShasanimmune-relatedbackground.IndeedthereisastrongevidencethataselectiveactivationofinnateimmunitymaybethetriggerforNCGSinflammatoryresponse.ThemostcommonlyautoimmunedisordersassociatedtoNCGSareHashimotothyroiditis,dermatitisherpetiformis,psoriasisandrheumatologicdiseases.ThepredominanceofHashimotothyroiditisrepresentsaninterestingfinding,sinceithasbeenindirectlyconfirmedbyanItalianstudy,showingthatautoimmunethyroiddiseaseisariskfactorfortheevolutiontowardsNCGSinagroupofpatientswithminimalduodenalinflammation.Onthesebases,anautoimmunestigmainNCGSisstronglysupported;itcouldbeacharacteristicfeaturethatcouldhelpthediagnosisandbesimultaneouslymanaged.ApossibleneurologicalinvolvementhasbeenunderlinedbyNCGSassociationwithglutenataxia,glutenneuropathyandglutenencephalopathy.NCGSpatientsmayshowevenpsychiatricdiseasessuchasdepression,anxietyandpsychosis.Finally,alinkwithfunctionaldisorders(irritablebowelsyndromeandfibromyalgia)isatopicunderdiscussion.Inconclusion,thenoveltyofthismatterhasgeneratedanexpansionofliteraturedatawiththeunavoidableconsequencethatsomereportsareoftenbasedonlowlevelsofevidence.Therefore,onlystudiesperformedonlargesampleswiththeinclusionofcontrolgroupswillbeabletoclearlyestablishwhetherthelargeinformationfromtheliteratureregardingextra-intestinalNCGSmanifestationscouldbesupportedbyevidence-basedagreements.