简介：DNAisacomplexmoleculethatisfoundinsidecells.Thismoleculeissosmallthatyoucan＇tnormallyseeitwiththenakedeye.Inthisexperiment,youwillcollectsomecellsfromtheskinontheinsideofyourmouth,breakthecellsopen,releasetheDNAandconcentratetheminaliquid,soyoucanseethem.

简介：AReviewofChina’sEconomicandSocialDevelopmentin2015Inthepastyear,Chinahasencounteredmanydifficultiesandchallengesinitsdevelopment.However,undertheleadershipoftheCentralCommitteeoftheCommunistPartyofChina(CPC)headedbyGeneralSecretaryXiJinping,andwithconfidenceandcourage,allthepeopleofChinahaveworkedtoovercomeobstaclesandhavepressed

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简介：Aim:ToevaluatetheeffectofaqueousCaricapapayaseedextractonmicroenvironmentofcaudaepididymis.Methods:Adultmalealbinoratswereintrauscularlyadministeredwith0(control)or0.5mgpapayaseedextract/kgbodyweightfor7days.Caudaepididymaltubularcontentwascollectedbymicropuncturetechnique;epididyrealluminalfluidandspermpelletswereseparatelyanalyzed.Results:Theresultsrevealedthattheextracttreatmentcausedsignificantreduction,ascomparedwithcontrol,intotalproteinandsialicacidcontentsinbothepididymalfluidandspermpellet.Ascomparedwithcontrol,significantlyloweredacidphosphataseactivitywasrecordedinspermpelletbutwashigherinepididymalfluidafterthetreatment.TheextracttreatmentalsocausedsignificantreductioninlevelofinorganicphosphorusintheePididymalfluid.Conclusion:Itisconcludedthattheaqueouspapayaseedextractalterscaudaepididymalmicroenvironment.

简介：MajorInitiativesof2015A.WemadenewstridesinkeyareasoflegislationThelawisofgreatvalueinthegovernanceofacountry,andgoodlawsareaprerequisiteforgoodgovernance.Focusingonthekeytaskofraisingthequalityoflegislation,wechanneledgreateffortintoadvancinglegislationinkeyareas.Largeinnumber,

简介：ReviewofWorkin2015In2015,theSPC,underthestrongleadershipoftheCentralCommitteeoftheCommunistPartyofChina(CPC)withComradeXiJinpingasGeneralSecretary,andundertheeffectivesupervisionoftheNationalPeople’sCongress(NPC)anditsstandingcommittee,profoundlystudiedandcarriedoutthespiritsofthe18thNationalCongressoftheCPC,andthethird,fourthandfifthplenarymeetingsofthe18thCPC

简介：Aim:ToevaluatetheantifertilityeffectofAlstoniascholarisbarkextractinmalerats.Methods:InmaleWistarratsAlstoniascholarisbarkextractwasgivenbyoralrouteatadoseof200mg/dayfor60days,Thefertilityandtesticularfunctionwereassessedbymatingtests,spermmotility,spermconcentration,biochemicalindicesandtesticularcellpopulationdynamics.Results:Oralfeedingwiththeextractatadoseof200mg/dayfortheperiodof60daysdidnotcausebodyweightloss,whiletheweightsoftestes,epididymides,seminalvesicleandventralprostateweresignificantlyreduced.Theproductionofstep-19spermatidswasreducedby79.6%intreatedrats.Thepopu-lationofpreleptoteneandpachytenespermatocytesweredecrasedby61.9%and60.1%,respectively.Spematogo-niaandSertolicellpopulationwerealsoaffected.TheseminiferoustubuleandLeydigcellnuclearareawerereducedsignificantly(P<0.01)whencomparedtothecontrols..Reducedspermcountandmotilityyesultedinatotalsupprs-sionoffertility.Asignificantfallintheproteinandsialicacidcontentofthetestes,epididymides,seminalvesicleandventralprostateaswellasglycogencontentoftesteswerealsonoticed.Thefructosecontentintheseminalvesiclewasloweredwhereasthetesticularcholesterolwaselevatedascomparedwiththecontrols.Thefollowingcom-poundswereobtainedfromtheextractwithchromatographicseparationoverSi-gelcolumn;α-amyrin,β-amyrin,lupiolacetate,venenative,rhazineandyohimbine,Conclusion:Atthedoselevelemployed,Alstoniascholarisbarkextracthasasignificantantifertilityeffectinmalerast;theprimarysiteofactionmaybepostmeioticgermcells(Step19spermatids).

简介：这份报告为金nanoparticles的合成描述Fagopyrumesculentum叶子的ethnolic摘录的使用。紫外可见的光谱学分析显示了金nanoparticles的成功的形成。综合nanoparticles被传播电子显微镜学(TEM)描绘，高分辨率TEM(HRTEM)并且被发现在有8.3nm的一种平均尺寸的形状球形、六角形、三角形。金nanoparticles的水晶的性质从X光检查衍射(XRD)和精选区域的电子衍射(SAED)被证实模式。Fourier变换红外线(英尺红外)并且精力散的X光检查分析(EDX)在金nanoparticles的表面上建议了器官的biomolecules的存在。对癌症房间衬里的人的HeLa，MCF-7和IMR-32的Cytotoxicity测试表明金nanoparticles是无毒的并且因此在各种各样的生物医学的应用为使用有潜力。

简介：XADisanapoptosisspecificDNaseinXenopusandcancutthelinker-DNAbetweennucleosomesduringapoptosisinXenopuslaeviseggextractinducedbycytochromec.XADismostlikelytobethehomologuetoDFF40inhumans.TheactivityofDFF40canbeinhibitedbyDFF45.WereportmolecularcloningandidentificationofanXADinhibitor,IXAD(inhibitorofXAD),inXenopuseggs.WeclonedthecompletecDNAoftheDFF45homologue,IXAD.ThereisaspecificDEVDsequenceinitsN-terminal,whichserves

简介：AIM:ToexaminetheprotectiveeffectsofGinkgobilobaextract(GbE)onthelearningandmemoryintheAlzheimerdisease(AD)modelinducedbyaluminumsaltinrats,andtoexaminethepotentialmechanisms.METHODS.TheADmodelofratswasinducedbyadministrationanddrinkingofaluminumchloridesolution.Theabilitiesofspatialleafingand

简介：AmethodforremovimgglucorapheninfromtheextractofRadishpigmentbyanionexchangeresin201×7wasstudied.Theadsorptioncapacityof201×7resinforglucorapheninwas72.8mg/mlresin,theequilibriumtime55minutes,andtheoptinumpH5.5.Allglucorapheninthathadbeenadsorbedon201×7resinwaselutedby1.5BV.hr^-1,eluentinwhincconcentrationofNaOHwas0.05mol·L^-1attheflowrateof1.5BV/h.Extractingsolutionofdeglucorapheninwasenrichedbyvacuumandspraydrying.ApowderproductofRadishpigmentwasobtainedandE1cm^1%=4.30.

简介：Juglansmandshurica格言的绿皮的摘录是为学习它的杀虫的活动并且分析活跃部件的提取bycommon方法。白酒摘录和氯仿摘录分开的Resultsshowed(用氯仿fromalcohol摘录分开了)J的形式绿色皮。mandshurica对LymantriadisparL的幼虫在接触toxicityand胃毒性举办杀虫的活动...在摘录forfive天的申请以后，为两篇摘录的Lymantriadispar的幼虫的改正的死亡是在≥的集中的超过50%in接触毒性和胃毒性5g·L~(-1)。为白酒摘录和摘录的氯仿部分的insecticidalactivity是在在胃毒性的接触toxicitythan的更多的效果，但是在杀虫的活动的重要差别都不是摘录的foundbetween白酒摘录和氯仿部分。在从绿皮of/mandshurica的氯仿partof摘录的活跃部件被GCMS分析。分析结果证明在氯仿的活跃部件摘录分开的thatthe是：(1)juglone(5-hydroxy-l,4-naphthaoquinone)，相对内容27.11%，(2)1,5-Naphthalenediol，相对内容9.52%，(3)7-Methoxy-l-tetralone，相对内容6.81%，(4)Benzofuran，2,3-dihydro-，relativecontent6.76%，(5)4-Hydroxy-2-methoxycinnamaldehyde，相对内容3.99%，(6)2-Methoxy-4-vinylphenol，相对内容3.05%。

简介：Therelationshipbetweentheadsorptionpropertiesfortheactivecomponentsofginkgoleavesandthestructureoftheadsorbentsbasedonurea-formaldehydecondensedpolymerswasinvestigated.Theresultsrevealedthattheseadsorbentsshowedveryhighadsorptonselectivityforbothflavonolglycosidesandterpenelactonescontainedinginkgoleaves.Thus,anadsorptionseparationprocedureforpurificationofginkgoleavesextractswasdeveloped.

简介：Thepresentresearcheffortwasaimedtodevelopcolontargeteddrugdeliverysystem(CTDDS)ofrhubarb,herbaldrugusingamixedfilmofpectinandethylcellulose(EC).Pectinandethylcelluloseweremixedinvariousproportionstocoatthecoretablettotargetcolon.Themethanolicextractofrhubarbwasusedandthedoseoftheextractineachformulationwasfinalizedbyestimatingtheemodincontentinitbyhighperformacethinlayerchromatography(HPTLC).Invitrodrugrelease,erosionstudyinpresenceandabsenceofpectinaseenzymeandreleaseconstant(K)ofzeroorderwasmeasuredforeachformulation.Theformulationwasoptimizedbyusing32fullfactorialdesign.Formulationhaving50%pectinasacoatingpolymerwith12%coatweightwasselectedasanoptimizedformulation(OF)onthebasisof%similaritywithmaximumdesirabilitybutthisformulationwasnotabletoretardthereleaseofdruginstomachandupperintestinefully.SoitwasfurthercoatedwithEudragitS100(ES)(3%coatweight).Theoptimizedformulation,coatedwithESindicatedsignificantlaxativeactivityonloperamideinducedconstipationinrats.TheresultsrevealedthatCTDDSofrhubarbusingtwocombinedapproachesofbiodegrablemicroflora-activatedsystemandpH-sensitivesystemexhibitedapromisingcolontargetingperformance.

简介：Oysterextractisaneffectivebioactivitycomponent.Ithasabundantnutritionalvalueandantiviral,antitumorandimmunedefensefunctions.Theroleofoysterextractintreatingliverinjuryhasbeenpaidmoreattention.WeuseWistarratstomakealcoholicliverdiseasemodelthroughinjectingalcoholintorats'stomachs.Theseratswererandomlydividedintofivegroups:modelgroup,controlgroup,low-dose,middle-doseandhigh-doseexperimentalgroupwithadoseof0.12gkg-1,0.40gkg-1,and1.20gkg-1alcoholic.Afternineweeks,serumbiomarkers(ALT,AST,TGandTCHO),malondialdehyde(MDA),glutathione(GSH),C3a,C5a,IL-17,TNF-ɑ,anti-MAA-HASIgG,CD3+,CD4+,CD8+,NKcellactivationandzinccontentwereassessed.Theresultsshowedthattheserumbiomarkers(ALT,AST,TGandTCHO),MDAcontent,anti-MAA-HSAIgG,serumC3a,C5aIL-17andTNF-ɑlevelsofoysterextracttreatmentgroupsweresignificantlydecreasedincomparisonwithmodelgroup.Onthecontrary,GSHshowedadversetrend.SerumCD3+,CD4+andNKcellactivationweresignificantlyincreasedinmiddle-dosegroupandhigh-dosegroupcomparedwithmodelgroup,andtherewasdecreaseofCD8+activityinhigh-dosegroup.PlasmaZnlevelwasdecreasedinmodelgroupcomparedwiththatincontrolgroup.Meanwhile,MeanplasmaZnlevelsincreaseddramaticallyfollowingthedoseincreaseofagivenoysterextract.

简介：PreliminaryworkbyourresearchteamrevealedthatSchisandra,arenownedtraditionalChinesemedicine,causeslearningandmemoryimprovementsinovariectomizedmice.ThisactivitywasattributedtoactiveingredientsextractedwithN-butylalcohol,namedSchisandraN-butanolextract.Inthisstudy,ovariectomizedmicewerepretreatedwithSchisandraN-butanolextractgivenbyintragastricadministration.Thistreatmentledtotheenhancementoflearning,andanincreaseinhippocampalCA1synaptic,surfaceandpostsynapticdensity.Adecreaseintheaveragesizeofthesynapticactivezonewasalsoobserved.TheseexperimentalfindingsshowingthatSchisandraN-butanolextractimprovedsynapticmorphologyindicateanunderlyingmechanismbywhichtheabilityoflearningisenhancedinovariectomizedmice.

简介：目的methotrexate(MTX)的最重要的副作用是mucositis。这研究的目的是在收到methotrexate的老鼠在肠的损坏和氧化应力上评估沉金摘录的效果。方法实验在划分成六个组的男Wistar白化体老鼠上被执行。首先组织收到的正常盐口头上地，第二个组收到了沉金摘录(100mg瑡潩?????????????????假吗？？

简介：TheaimofthisstudyistoelucidatethemolecularandcellularmechanismsunderlyingtheimmunosuppressiveeffectofSanchiextract(SE)viainvestigatingtheeffectsofSEontheactivationandproliferationofmurinelymphocytesandNOsecretionbyperitonealmacrophagesinvitro.ConAwasusedtoactivatelymphocytes,andexpressionofCD69onTcellsandCFSElabeledcelldivisionweredetectedbyflowcytometry.MurineperitonealmacrophageswerestimulatedwithLPSorlymphocytesculturesupemate(LCS)andtheconcentrationofNOwasdeterminedbyGriessreagentassay.After6hofculture,SErangingfrom50to100μg/mldownregulatedCD69expressiononConA-activatedTcells,whileSErangingfrom12.5to100μg/mlinhibitedtheproliferativeresponseoflymphocytestoConA.Additionally,SE(12.5-100μg/ml)inhibitedsecretionofNObyperitonealmacrophagesstimu-latedbyLPSorLCS.ThisstudyrevealsthatSEinhibitstheactivationandproliferationofmurinelym-phocytesandNOsecretionbyperitonealmacrophages.

简介：Nigellasativa悬崖的种子。(Ranunculaceae)，通常已知的同样黑的枯茗，主要被用作排除胃肠气体，镇痉药，和兴奋剂。现在的学习的主要目的是评估N的效果。越过内脏墙的共同灌输的amoxicillin的浸透上的sativa种子摘录。N的methanolic摘录。sativa以一种剂量依赖者方式在in-vitro实验改进了amoxicillin的肠的渗透。二新glycosides，decanylnigelloic酸diglucoside[n-decanyl-3-aldehydic-4-methoxy-5-hydroxybenzoate-5--D-glucofuranosyl(21)--D-glucopyranosyl-(21)--D-glucopyranoside]]并且nigelabdienoyltriglucoside[homo-labd-5，9(11)-dien-16-onyl--D-glucopyranosyl(21)--D-glucopyranosyl(21)--D-glucopyranoside]与七已知的丰满的酸glycerides/esters一起，从提高摘录的内脏浸透被孤立。这些新glycosides的结构被详细分光镜的分析阐明。

简介：Thesynthesisofnontoxicstablegoldnanoparticlesisimportantformedicalapplications.AnaqueousextractoftheplantStachyslavandulifoliaVahlwasusedtosynthesizegoldnanoparticles.ThisgreenmethodinvolvedtheS.lavandulifoliaVahlextractactingasareducingandstabilizingagent.Thenanoparticleswerecharacterizedbytransmissionelectronmicroscopy,dynamiclightscatteringanalysisandUV-visabsorptionandFouriertransform-infraredspectroscopies.Stabilityunderphysiologicalconditionsisimportantformedicalapplications.Thestabilityofthenanoparticleswascomparedwiththatofconventionalcitrate-cappednanoparticles,underbothsyntheticandphysiologicalconditions.ThenanoparticlessynthesizedfromtheS.lavandulifoliaVahlextractwerestableunderphysiologicalconditions,incontrastwithconventionalcitrate-cappednanoparticles.