简介：一种新型碳酸酐酶抑制剂（CAI）：通过抑制睫状体中的碳酸酐酶的活性，减少房水生成和减少房水流量，从而能有效降低眼内压。服用后一般在2—4小时内生效，在6-8小时内达到最佳疗效，10—18小时仍有效。

简介：AIM:ToinvestigatetheeffectofintravitrealinjectionofDL-alpha-aminoadipicacid(DL-α-AAA)onocularrefractivestateandretinaldopamine,transforminggrowthfactor-β2(TGFβ2),vasoactiveintestinalpolypeptide(VIP)inguineapigform-deprivedmyopia.METHODS:Four-week-oldpigmentedguineapigswererandomlyassignedto4groups:normalcontrol,deprivation,deprivationplusDL-α-AAA,deprivationplussaline.Formdeprivationwasinducedwiththeself-madetranslucenteyeshields,andlastedfor14days.8μgDL-α-AAAwasinjectedintothevitreouschamberofdeprivedeyes.Thecornealradiusofcurvature,refractionandaxiallengthweremeasured.Retinaldopaminecontentwasevaluatedbythehigh-performanceliquidchromatographywithelectrochemicaldetection,andTGFβ2andVIPproteinweredetectedbyWesternblotting.RESULTS:Fourteendaysofeyeocclusioncausedtheaxiallengthtoelongateandbecomemyopicintheform-deprivedeyes,withthedecreaseofretinaldopamineandtheincreaseofTGFβ2andvasoactiveintestinalpolypeptide(VIP)protein.IntravitrealinjectionofDL-α-AAAcouldinhibitthemyopicshiftfrom(-3.65±1.06)Dto(-1.48±0.63)D,P<0.01duetogogglesoccludingandcausethedecreaseofretinalTGFβ2proteininthedeprivedeyes.However,intravitrealinjectionofDL-α-AAAhadnosignificanteffectonretinaldopamineandVIPproteinindeprivedeyes.RetinalTGFβ2proteincorrelatedhighlywiththeocularrefraction(y=-3.34+0.31/x,F=74.75,P<0.001)andaxiallength(y=8.39-0.02/x,F=48.32,P<0.001)indifferenttreatmentgroups.·CONCLUSION:IntravitrealinjectionofDL-α-AAAiseffectivelyabletosuppressthedevelopmentofformdeprivationmyopia,whichmaybeassociatedwithretinalTGFβ2proteininguineapigs.

简介：目的：分析总结2．5g／L马来酸噻吗洛尔眼液（timolol）对准分子激光原位角膜磨镶术（laserinsitukeratomileusis，LASIK）后屈光回退的治疗效果。方法：选取我院准分子中心2007—08／2008—08接受LASIK手术病例1400例2650眼，随访0．5a以上，发生屈光回退者有53例66眼，按手术时间随机分为两组，试验组使用2．5g／L马来酸噻吗洛尔眼液进行治疗，对照组使用1g／L玻璃酸钠眼液进行治疗，两组治疗时间均为2wk，治疗结束后将试验组与对照组进行分析比较（视力提高行数）。结果：试验组视力提高-1～4（平均1．45±1．09）行，对照组视力提高．2～2（平均0．61±0．86）行，行成组t检验显示，两组差异有统计学意义（t=3．500，P〈0．05）。结论：马来酸噻吗洛尔眼液2．5g／L对LASIK术后屈光回退具有显著疗效。

简介：目的：研究视网膜血管疾病在印度喜马偕尔邦丘陵地带（海拔500～4500m）的患病模式/分布。方法：对西姆拉三级医院眼科自2008-08/2013-04期间的视网膜疾病患者进行回顾/前瞻性研究。选取5600位中的4323名患者作为研究对象。该数据均来自于医院记录,随后根据患者的年龄,性别分布情况和诊断结果进行分析。所有患者都进行了视力,屈光,裂隙灯和眼底检查。以眼底临床记录和眼底照相记录来确定诊断。应用眼底照像机（KowaFundusCameraVX-10）进行照相,必要时进行眼底荧光素血管造影。结果：在4323例患者中,男性视网膜疾病患者有2563例（59.29%）,多于女性1760例（40.71%）。在525例（12.14%）糖尿病视网膜病变患者中,轻度非增殖性糖尿病视网膜病变133例（3.08%）,中度156例（3.60%）,重度120例（2.78%）,增殖性糖尿病视网膜病变116例（2.68%）。在393例（9.10%）高血压性视网膜病变患者中,I级高血压性视网膜病变患者130例（3.01%）,II级111例（2.57%）,III级131例（3.03%）,IV级21例（0.49%）。在660例（15.27%）其他视网膜血管疾病中,视网膜分支静脉阻塞229例（5.30%）,视网膜中央静脉阻塞55例（1.27%）,半视网膜中央静脉阻塞8例（0.19%）,视网膜中央动脉阻塞20例（0.46%）,视网膜分支动脉阻塞4例（0.09%）,眼部缺血综合征1例（0.02%）,早产儿视网膜病变9例（0.21%）,视网膜大动脉瘤5例（0.12%）,近中心凹毛细血管扩张6例（0.14%）,贫血性视网膜病变16例（0.37%）,白血病视网膜病变10例（0.23%）,视网膜前出血52例（1.20%）,Coats病8例（0.19%）,睫状视网膜动脉阻塞1例（0.02%）例,Eales病10例（0.23%）,血管炎17例（0.39%）以及有临床意义的黄斑水肿209例（4.83%）。结论：糖尿病视网膜病变是最常见的视网膜血管疾病。视网膜疾病已经成为印度一个主要公共卫生问题。此研究将有利于对喜�

简介：AIM:ToinvestigatetheexpressionsoftypeIcollagen,α2integrinandβ1integrinintheposteriorscleraofguineapigswithdefocusmyopiaandwhetherbasicfibroblastgrowthfactor(bFGF)injectioninhibitstheformationanddevelopmentofmyopiabyupregulatingtheexpressionoftypeIcollagen,α2integrinandβ1integrin.METHODS:After14daysoftreatment,therefractivestateandaxiallengthweremeasuredandthelevelsoftypeIcollagen,α2integrinandβ1integrinwereassayedintheposteriorscleraeofgroupsofguineapigsthatworeamonocular-7Dpolymethylmethacrylate(PMMA)lensorhad-7DlenswearfollowedbytheperibulbarinjectionofPhosphateBufferSolution(PBS)orbFGF.Theuntreatedfelloweyeservedasacontrol.Guineapigswithnotreatmentservedasnormalgroup.·RESULTS:Theresultsshowedthat14daysofmonoculardefocusincreasedaxialeyelengthandrefraction,whilebFGFdeliveryinhibitedthemmarkedly.Further,itwasalsofoundthatthemonocular-7DlenscoulddecreasethelevelsoftypeIcollagen,α2integrinandβ1integrinexpressions,while,unlikePBS,bFGFincreasedthemsignificantlyincomparisontocontralateralcontroleyesandnormaleyes.CONCLUSION:bFGFcanpreventtheformationanddevelopmentofdefocusmyopiabyupregulatingtheexpressionsoftypeIcollagen,α2integrinandβ1integrin.Takentogether,ourresultsdemonstratethatbFGFpromotesscleraremodelingtopreventmyopiainguineapigs.