简介:BACKGROUND:Conventionalmethods(suchasocclusiontherapy,finemanipulation,complementary,andalternativemedicine)takeeffectsslowly,aretimeandlaborconsuming,andhaveuncertaincurativeeffectsinthetreatmentofamblyopia.Perceptuallearning,anewmethodfortreatingamblyopia,improvestheabilitytoprocesssignalsfromthecerebralopticnervesystembyspecificvisualstimulationandvisuallearning,aswellasactivationofthevisualsignalpathwayutilizingbrainnervoussystemplasticity.OBJECTIVE:Thisstudyinvestigatedandevaluatedthecurativeeffectsofperceptuallearning,whichcandirectionallyincreasebrainplasticity,onthetreatmentofamblyopiainchildren.Therelationshipbetweencurativeeffectandtimewasalsoanalyzed.DESIGN:Aself-controlexperiment.SETTING:VisualScienceandOptometryCenter,People'sHospitalofGuangxiZhuangAutonomousRegion.PARTICIPANTS:Atotalof125amblyopicchildren(250amblyopiceyes),73males,52females,averaging(6±2)yearsofage,receivedtreatmentattheVisualScienceandOptometryCenter,People'sHospitalofGuangxiZhuangAutonomousRegionbetweenSeptember2006andFebruary2007andwererecruitedforthisstudy.Allchildrenpresentedwithnostructuraldiseaseoftheeyeballs.Writteninformedconsentfortherapeuticregimentswasobtainedfromeachchild'sparent.TheprotocolreceivedapprovalfromtheHospital'sEthicsCommittee.METHODS:Visualfunctionwastestedwithaperceptuallearningsystem(ResearchCenterforHumanHealthandDevelopmentofSunYat-senUniversity,NationalEngineeringTechniqueResearchCenterforMedicalCareImplement)forvisualnoise,positionnoise,contourdiscrimination,contrastsensitivity,gratingstereogram,andrandom-dotfusion.Thesetestshelpedtoevaluatetheefficiencyofvisualinformationprocessingofthesechildren,andtodeterminethedegreeofdefectsoftheopticnervecellsandtheconnectionsofvisualcorticalneurons.Accordingtoresultsofvisualfunct
简介:AIM:TodeterminethevisualoutcomesinadultpatientswhosustainedopenglobeinjuriesandtodeterminewhetherthevisualprognosisfollowinganeyeinjuryinanAfricansettingdiffersfromthepredictedoutcomesaccordingtotheOcularTraumaScore(OTS)study.AsecondaryaimwastoestablishtheeviscerationratefortheseinjuriesandassesshowthisformofinterventionaffectedoutcomesincomparisontotheOTS.·METHODS:Aprospectivecaseseriesofallpatientsadmittedwithopenglobeinjuriesoveratwo-year(July2009toJune2011)period.InjurieswerescoredusingtheOTSandthesurgicalinterventionwasrecorded.Thebestcorrectedvisualacuityatthreemonthswasregardedasvisualoutcome.·RESULTS:Therewere249openglobeinjuries,ofwhich169patients(169eyes)completedthe3-monthfollow-up.Allpatientsunderwentprimarysurgery,175(70.3%)repairs,61(24.5%)eviscerationsand13(5.2%)otherprocedures.GlobeeviscerationsweremainlydoneonOTSCategory1cases,butoutcomesinthiscategorywerenotfoundtobedifferentfromOTSoutcomes.OutcomesweresignificantlyworseinCategory2,butwhentheentiredistributionwastested,thedifferenceswerenotstatisticallysignificant.TheoverallassociationbetweenOTSoutcomesandthefinalvisualoutcomesinthisstudywasfoundtobeastrong(P<0.005).·CONCLUSION:Reliableinformationregardingtheexpectedoutcomesofeyeinjurieswillinfluencemanagementdecisionsandpatientexpectations.TheOTSisavaluabletool,theuseofwhichhasbeenvalidatedinmanypartsoftheworld-itmayalsobeavalidpredictorinanAfricansetting.
简介:蜜蜂(Apismellifera)是有强壮的感觉能力和多样的行为的全部剧目的一只社会昆虫并且为学习学习和记忆的neurobiological基础作为一个好模型有机体被认出。在这研究,我们在microRNA(miRNA)和跟随用下一代的小RNA定序和介绍的Solexa/lllumina数字基因表示标签(DGE)的基于迷宫的视觉学习的送信人RNA(mRNA)分析了变化。为定序的小RNA,我们分别地从迷宫和控制组获得了13367770和13132655个干净标签。40差别的一个总数表示了已知的miRNAs在这二件样品之间被检测,并且所有他们在与控制组相比的迷宫组是起来调整的。为DGE,5681320和5939855个干净标签分别地从迷宫和控制组被检测。有388差别的一个总数表示了在这二件样品之间的基因,与起来调整的45基因和在迷宫组下面调整的343基因,与控制组相比。另外,10差别的表示层次表示了基因被量的反向的抄写聚合酶链反应(qRT-PCR)证实,他们中的八个的表示趋势与DGE结果一致,尽管变化的度在振幅是更低的。miRNA和mRNA表示的综合分析显示出那,在表示的40差别之中已知的miRNAs和388差别表示了基因,miRNA/mRNA的60pairs是在我们的现在的学习共同表示被识别。这些结果建议miRNA和mRNA可以在在蜜蜂学习和记忆的进程起一个枢轴的作用。我们的定序的数据为基于迷宫的视觉学习提供全面miRNA和基因表达式信息,它将便于蜜蜂学习和存储器的分子的机制的理解。
简介:为neovascular在诊断和预后调查neutrophil-to-lymphocyte比率(NLR)和platelet-to-lymphocyte比率(PLR)的地方年龄相关的有斑点的退化(AMD).METHODSOne百个AMD病人和100健康控制在学习被包括。血样品从静脉的血被获得,它被用于平淡的分析,并且这些样品被使遭到完成血计数。NLR被定义为淋巴细胞的数字划分的嗜中性的计数,并且PLR被定义为lymphocytes.RESULTSNo的数字划分的血小板计数统计上重要的差别以人口统计的特征在考虑下面在二个组之间被观察(P>0.05)。在耐心的组的平均NLR被发现在健康控制组比那显著地高(P<0.05)。平均PLR作为与控制组相比在耐心的组是显著地更高的(P<0.05)。当最好改正的视觉尖酸(BCVA)增加了,NLR和PLR减少了(在49.8%和63.0%点的重要否定关联,分别地)而当中央有斑点的厚度(CMT)增加了,NLR和PLR增加了(在59.3%和70.0%点的重要积极关联,分别地).CONCLUSIONNLR和PLR层次作为与健康控制相比在neovascularAMD病人之中是更高的组。NLR和PLR层次被发现与BCVA并且直接相反地成正比与CMT成正比。
简介:AIMTo调查经历了intravitrealranibizumabmonotherapy对待neovascular的病人的长期的视觉、解剖的结果年龄相关的有斑点的退化(AMD)并且为经历了ranibizumabmonotherapy因为neovascularAMD在这回顾的study.RESULTSThe一般水准病人年龄被包括的74个病人的74只眼睛的至少2y.METHODSA总数跟随起来是72.1
简介:AbstractObjective:To compare and correlate the efficacy of the NOSE score & the VAS score in determining the symptomatic benefit in patients undergoing septoplasty.Materials and methods:Eighty patients with deviated nasal septum undergoing septoplasty were included in the study. NOSE score & VAS score (out of 100) was documented before and after surgery. Results were correlated and compared statistically.Results:In the NOSE score, the most bothersome symptom was trouble breathing through the nose (85.83); followed by Nasal obstruction or blockage (82.50). Wilcoxon test showed significant improvement with NOSE score and VAS score in all patients at 1 month and 3 months. Spearman’s coefficient showed a positive correlation between the two, though the score improvement and patient satisfaction rate was significantly high with NOSE score.Conclusions:NOSE score and the VAS score both provide effective framework for evaluating treatment responses after septoplasty. However, the NOSE score showed higher improvement and better patient satisfaction rate when used to measure of nasal obstruction as compared to the VAS score.
简介:AIMTo在situkeratomileusis(FS-LASIK)在femtosecond激光以后比较视觉质量,在之间同轴地角膜的轻反射(CSCLR)组和常规脱离视觉(LOS)衬里的sightedgroup.METHODSIn总数,243只眼睛(122个病人)在CSCLR(视觉轴)上与centration被对待,238只眼睛(119个病人)在学生中心(LOS)上与centration对待。手术后的结果[未改正的视觉尖酸(UCVA),最好的改正景色的视觉尖酸(BSCVA)],安全索引,功效索引,折射结果,从视觉轴的脱离中心距离,角膜的高顺序的错误,主观不快瞪视和shadowing发生率,和对比在1点的敏感,3,并且6mo被测量,compared.RESULTSThe平均数年龄是27.77
简介:AIM:Toinvestigatetheinfluencingfactorsofvisualfieldimprovementaftertrans-sphenoidalresectionofpituitarymacroadenomas.·METHODS:Thisretrospectivecohortstudyincluded201patients(366eyes)withvisualfielddefectinducedbypituitarymacroadenomas.Allofthemweretreatedwithtrans-sphenoidalsurgery.Ophthalmologicevaluation,best-correctedvisualacuity(BCVA),andvisualfieldexaminationwereperformedbeforeand3moaftersurgery.BCVA,visualfielddefectindexmeandeviation(MD),durationofsymptoms,age,sex,andvolumeoftumorswerecompared.Expressionofvascularendothelialgrowthfactor(VEGF)andKi-67oftumortissueweredetectedbyimmunohistochemicaltechnique.·RESULTS:Themeanageofpatientswas44.23±1.29y.Ninety-threepatientswerefemaleand108weremale.Themeantumorvolumewas14.36±6.23cm~3.Themeandurationofpreoperativesymptomswas11.50±0.88mo.MeanpreoperativeMDwas-17.50±0.82dB.MeanPreoperativevisualacuitywas0.64±0.04.Postoperativevisualfieldimprovedin270(73.77%)eyes,unchangedin96(26.23%)eyes.Multivariatelogisticregressiondisplayedthatthefactorsindependentlyinfluencingvisualfieldimprovementwereyoungage(OR=1.71,95%CI:1.325-2.387,P=0.013),lowpreoperativeMDabsolutevalue(OR=1.277,95%CI:1.205-1.355,P<0.001),smallvolumeoftumor(OR=1.458,95%CI:1.060-4.289,P<0.001),lowexpressionofVEGFintumortissue(OR=1.554,95%CI:1.089-2.457,P=0.022),andlowexpressionofKi-67intumortissue(OR=1.552,95%CI:1.161-2.847,P=0.026).·CONCLUSION:Afterpituitarymacroadenomastranssphenoidalresection,theindependentinfluencingfactorsofthevisualfieldsrecoverywerelowpreoperativeMDabsolutevalue,youngage,smallvolumeoftumor,andexpressionlevelsofVEGF/Ki-67.
简介:摘要:指出了建筑工程造价行业成果文件编制的现状;介绍利用Visual Basic6.0编程读对Excel数据实现编制Word造价成果报告的方法。在文章中给出了实现这些功能的关键程序源代码,在最后指出了应用Visual Basic6.0编程应该注意的事项。
简介:AIM:Tostudytheeffectsofdifferentflapsizesonvisualacuity,refractiveoutcomes,andaberrationsafterfemtosecondlaserforlaserkeratomileusis(LASIK).·METHODS:Ineachofthefortypatientsenrolled,1eyewasrandomlyassignedtoreceivetreatmentwitha8.1mmdiametercornealflap,definedasthesmallflap,whiletheothereyewastreatedwitha8.6mmdiametercornealflap,definedasthebigflap.Refractiveerrors,visualacuity,andhigher-orderaberrationswerecomparedbetweenthetwogroupsatweek1,month1and3postoperatively.·RESULTS:Thepostoperativerefractiveerrorsandvisualacuityallconformedtotheintendedgoal.Postoperativehigher-orderaberrationswereincreased,especiallyinsphericalaberration(Z12)andverticalcoma(Z7).Therewerenostatisticallysignificantdifferencesbetweenthetwogroupsintermsofpostoperativerefractiveerrors,visualacuity,rootmeansquareoftotalHOAs(HO-RMS),trefoil30°(Z6),verticalcoma(Z7),horizontalcoma(Z8),trefoil0°(Z9),andsphericalaberration(Z12)atanypointduringthepostoperativefollow-up.·CONCLUSION:Boththesmallandbigflapsaresafeandeffectiveprocedurestocorrectmyopia,providedtheexposurestromameetstheexcimerlaserablations.Thepersonalizedsizecornealflapisfeasible,aswecandesignthesizeofcornealflapbasedontheprinciplethatthecornealflapdiametershouldbeequaltoorgreaterthanthesumofthemaximumablationdiameterandapparatuserror.
简介:摘要目的研发一款"酸碱平衡紊乱分析软件",用于快速判断酸碱平衡紊乱(酸碱失衡)的类型。方法以Henderson-Hasselbalch方程式和代偿公式为基础建立数学模型,确定酸碱失衡分析的重要参数,制定分析流程。使用Visual Basic 2010.NET编程语言完成软件的编译,调试后生成安装程序包。用计算机检索PubMed、万方和中国知网数据库中从1980至2015年发表的酸碱失衡案例文献,详细记录每个案例提供的血气参数〔pH、动脉血二氧化碳分压(PaCO2)、碳酸氢根(HCO3-)和阴离子隙(AG)〕及酸碱失衡类型(文献结果);使用软件对上述案例的酸碱失衡类型重新进行分析得出判断(软件分析结果),对两种判断结果进行Kappa一致性检验和McNemar配对χ2检验。结果以"四参数-四步骤"程序化分析方法作为判断酸碱失衡类型的分析流程。其中,"四参数"指pH、PaCO2、HCO3-和AG。"四步骤"概述为:①根据pH初步判定血气的酸碱状态,结合HCO3-、PaCO2判断酸碱失衡的原发类型;②根据代偿情况判断是否存在双重混合型酸碱失衡(DABD);③根据AG判断是否存在三重混合型酸碱失衡(TABD);④使用ΔAG↑/ΔHCO3-↓比值,判断AG增高型代谢性酸中毒(AG↑型代酸)是否同时伴有代谢性碱中毒(代碱)或AG正常型代酸。"酸碱平衡紊乱分析软件"具备界面简洁、操作方便、判断迅速、分析结果系统而全面的特点,可以判断除"AG正常型代酸合并代碱"以外的所有酸碱失衡类型。应用"酸碱平衡紊乱分析软件"对文献报道的112例酸碱失衡案例进行再次分析,软件分析结果与文献结果的一致率为87.50%,具有较好的一致性(Kappa检验:κ=0.84,P<0.01;McNemar检验:χ2=0.87,P=0.65)。结论"酸碱平衡紊乱分析软件"可以作为判断酸碱失衡类型的重要工具,为临床医生提供诊断参考,具有很高的实用价值和应用前景。