简介：AIM:Toevaluatewhetherthelevelofthrombospondin-1(TSP-1)inaqueoushumorcanpredicttheprognosisoftrabeculectomyinpatientswithprimaryangle-closureglaucoma(PACG).METHODS:Thiscase-controlstudyinvolved26patientswithPACGwhoexperiencedafailedtrabeculectomy(casegroup)and78age-andsex-matchedpatientswithPACGwhounderwentsuccessfultrabeculectomy(controlgroup).AqueoushumorwascollectedatthetimeoftrabeculectomyandtestedforTSP-1andTGF-β2levelswithanenzyme-linkedimmunosorbentassaymethod.Logisticregressionmodelingwasusedtoassesstheriskfactorsforfailedtrabeculectomy.RESULTS:ThemeanTSP-1aqueousconcentrationsweresignificantlyhigherinthecasegroup(20.67±9.79ng/mL)thanthecontrolgroup(5.17±2.29ng/mL)(P<0.001).Thetransforminggrowthfactor-β2(TGF-β2)aqueousconcentrationsweresignificantlydifferentbetweenthecaseandcontrolgroup,at3633.25and1090.24pg/mL,respectively(P<0.001).LogisticregressionanalysisrevealedTSP-1levelasanindependentriskfactorforafailedtrabeculectomy(OR=3.540;95%CI=1.092-11.482).CONCLUSION:TheaqueoushumorTSP-1andTGF-β2levelsarehigherinPACGeyeswithfailedtrabeculectomythanwithsuccessfultrabeculectomyatoneyear.TheaqueoushumorTSP-1levelisanindependentriskfactorassociatedwithfailedtrabeculectomy.

简介：·Descemet’smembranedetachment(DMD)canbeapotentiallyseriouscomplicationofintraocularsurgeryoroculartrauma.Thecauseisnotveryclear.WearetryingtoremindanawarenessofthespectrumofDMDresultingfromtrabeculectomybypresentingacaseofextensiveDMDaftertrabeculectomywhichwassuccessfullyrepaired.

简介：AIMTo系统地基于快速的培植和trabeculectomy(Trab)的功效和费用考察当前的证据因为不受管束的glaucoma.METHODSClinical审判被电子数据库(PubMed，EMBASE，科学的ISI网和Cochrane图书馆)识别，并且数据例如intraocular压力(IOP)，完全、合格的成功率，手术后的复杂并发症和费用，是从这些相关研究的exacted。加权的吝啬的差别(WMD)，机会比率(或)并且95%信心间隔(CI)用相关出版物和二篇摘要遇见了的随机效果的model.RESULTSEleven被计算并且被分享包括标准。快车的功效在1点类似于在IOP减小(IOPR%)的百分比的Trab的，2y(WMD：-2.01；95%CI：-7.92-3.90；P=0.50和WMD：2.89；95%CI：-8.05-13.83；P=0.60，分别地)。快车拥有了重要更高完全、合格的成功率(或：1.59；95%CI：1.07-2.35；P=0.02并且或：1.74；95%CI：1.06-2.86；P=0.03，分别地)。而且，快车比Trab施加了hypotony和hyphema的显著地更低的频率(或：0.39；95%CI：0.21-0.72；P=0.003并且或：0.27；95%CI：0.10-0.69；P=0.003，分别地)。然而，根据以前的三studies.CONCLUSIONBothTrab和快车在二个组之间的费用上没有一致结果在阴沉的IOP有相等的功效，还快速比Trab有hypotony和hyphema的更低的风险。不过，快车的费用是否是不到Trab的应该进一步被调查长远来说保证基于证据的结论。

简介：·AIM:Toinvestigatetheantifibroticeffectoffreeze-driedbilayeredfibrin-bindingamnioticmembraneontrabeculectomyinarabbitmodel.·METHODS:Twenty-fourJapanesewhiterabbitswererandomizedintothreegroups:theexperimentalgroup(oculartrabeculectomyincombinationwithfreeze-driedbilayeredfibrin-bindingamnioticmembranetransplantation),thecontrolgroup(oculartrabeculectomyincombinationwithnaturalbilayeredfibrin-bindingamnioticmembrane)andtheblankgroup(singletrabeculectomy).Clinicalobservation,hematoxylin-eosinstaining,Massionstaining,real-timePCRandimmunohistochemistryforα-SMAwereperformedondays7,14,21and30followingsurgery.·RESULTS:Statisticaldifferenceswerenotedinsurvivalanalysisandintraocularpressure(IOP)amonggroupsondays7,14,21and30followingsurgery.Histology,immunoh-istochemistryandreal-timePCRfurtherdemonstratedthattrabeculectomyincombinationwithfreeze-driedbilayeredfibrin-bindingamnioticmembraneresultedingoodwoundhealingandnoscarformation.·CONCLUSION:Self-madefreeze-driedbilayeredfibrin-bindingamnioticmembranemayinhibittheformationofscarringinglaucomaaftertrabeculectomy.·