简介：摘要 目的：探究基因组DNA污染及乳腺癌单样本预测器(single sample predictor, SSP)在RNA-seq中鉴定Basal-like亚型乳腺癌的一致性与稳健性。方法：使用4种SSP联合3种数据校正方法，按比例随机去掉一定比例的非Basal-like亚型样本，并使用正态分布模拟基因组DNA对基因表达量的影响。结果：数据校正方法影响乳腺癌SSP鉴定Basal-like亚型的一致性(κ=0.733-0.964)；乳腺癌SSP可以一致鉴定出Basal-like亚型(κ=0.846-0.958)，对Basal-like亚型鉴定的稳健性高；基因组DNA污染对Basal-like亚型鉴定的一致性影响较小(κ=0.922-1)。结论：Basal-like亚型的鉴定具有高度的一致性与稳健性且受基因组DNA污染影响较小。

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简介：上一期中，我们介绍了Lucy的家人，你还记得吗？今天，来认识一下Lucy在学校的英语老师和Mary的法语老师!Mary是谁？去文中找找看!

简介：我喜欢春天，因为我喜欢暖暖的风。我喜欢夏天，因为我喜欢冰激凌。我喜欢秋天，因为我喜欢新鲜的苹果。我喜欢冬天，因为我喜欢堆雪人。

简介：“wouldlike”和“feellike”都有“想要”之意，但它们的含义和用法又有不同，下面谈谈它们的差异。

简介：AbstractIntroduction:Basal cell carcinoma (BCC) is the most common human malignancy commonly in white people, but in less than 1% of cases it may appear on unexposed areas, like the perineal and anal regions. Vulvar BCC is often diagnosed late because it grows slowly and tends to be asymptomatic, with no specific physical findings. Here, we present a rare Latin patient with a 10-year history of vulvar BCC with dermatoscopic and histopathologic findings.Case report:A 65-year-old Latin woman presented with a nodule on her left labium majus, which she first noted 10 years ago, and that had grown slowly but constantly. She also reported a 20-year history of pruritus and occasional pain. Physical examination showed a 3.5 cm × 3.0 cm erythematous lesion with a central rough without inguinal lymphadenopathy. Contact dermatoscopy (Dermalite DL3 Gen.) showed one blurred cluster of arborising vessels in a pinkish background with white homogeneous areas and lines radial converging. An incisional biopsy was realized, and histopathology diagnosed BCC.Discussion:Vulvar BCC is a rare malignancy that affects mainly Caucasian women over 70 years of age. The most common etiology for BCC is ultraviolet radiation, but as the vulva is unexposed its cause is unclear. Mutations in tumor suppressor and regulatory genes such as p53 are present in 50% of cases. Gorlin syndrome, chronic radiation, chronic arsenic exposure, xeroderma pigmentosum, and immunosuppression have been considered as risk factors.Conclusion:Vulvar BCC characteristics are the same as other cutaneous forms, featuring blue ovoid nests and arborizing telangiectasia, confused with inflammatory diseases, such as eczema, psoriasis, and chronic infection (especially if it is accompanied by pruritus), this makes diagnosis complex, with a delay of 5 to 6 years on average, with an average size of 2.1 cm. Diagnosis is enhanced with dermatoscopy, as the preferred treatment for most BCC cases is wide surgical excision.

简介：AbstractIntroduction:Basal cell carcinoma (BCC) is the most common skin cancer which mainly affects the population over 50 years of age. In addition to surgical treatment, nonsurgical treatment is also an attractive option for some patients.We herein report a case of an 82-year-old man with BCC successfully treated with acitretin.Case presentation:An 82-year-old man presented with BCC on his left nose wing more than 2 years ago. Due to his unwillingness to accept treatment that may lead to pain, discomfort, or trauma, the patient was prescribed oral acitretin 25 mg twice daily [0.8 mg/(kg·d)] and was instructed to apply 2% fusidic acid cream topically once daily for trauma protection. The lesion progressively shrank in size after 4 weeks of treatment, and was almost completely resolved after 28 weeks of follow-up. The patient reported mild adverse effects, such as mild skin fragility and cheilitis, and apparent scaling skin, which caused minor discomfort but did not affect the continuation of treatment.Discussion:The pathogenesis of BCC is still unclear, but it has been demonstrated to be linked to overactive hedgehog signaling and its crosstalk with other pathways such as phosphoinositide 3-kinase and mammalian target of rapamycin. Acitretin could obviously inhibit cell growth and proliferation and down-regulate AMP-dependent protein kinases that plays critical role in the blocking of malignant progression of several tumors including BCC.Conclusion:We provide an effective alternative for the patients with BCC who are unwilling to receive surgical therapy.

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简介：Yearsonthescene,musicianandpromoterJonCampbellhaslearnedwhatChina'smusicfanswanttohear-andpayfor.

简介：DongWenguangwasagrandsonofDongHe.HewasbornatthebeginningoftheNorthernSongDynasty.Theemperoradvocatdeforcultureandlaunchedimperialexaminations.DongWenguangwasfar-sightde.Hebegantorunschools.Helaiddownstrictfamilyrules,tellingthesonsanddaughtersofthefamilytoreadbooks.

简介：Ilovepotatoes.Potatoesareverydelicious.Therearemanywaystocookpotatoes,suchasmashedpotatoes,Frenchfries,potatosalad.AndIlikeFrenchfriesbest,it’smyfavoritesnack.Besides,potatoesarefullofnutrition.Weshouldeatmorepotatoes.Trythem,Ithinkyou’lllikethem.(指导老师:钱莹)

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简介：like是中学英语中相当活跃的一个词，其用法和意义非常广泛，可以充当动词、形容词、连词、介词等，而且高考试题对like也多有测试。笔者认为很有必要对like的用法及考点予以归纳，供同学们学习参考。

简介：Ilikelanternsverymuch.Look,thislanternlookslikeatiger.Thatlanternlookslikeabutterfly.Thisonelookslikealotus.Thatonelookslikeabigpeach.Theyaresobeautiful.

简介：Rabbitsareverycute.Theyhavetwolongearsandtworedeyes.Theyhavefourlegsandasmalltail,too.Theycanrunandjump.Theylikecarrots.Ilikerabbitsverymuch.指导老师:周兆群

简介：Therearefourseasonsinayear.Myfavoriteseasonisspring.Becausesummeristoohotandwinteristoocold.Springiswarmandsunny.Animalswakeupfromwintersleep.Plantsbegingrowingandturninggreenagain.Peoplecanspendtimeoutdoors,dosomeexerciseorgopicnicing.Everyspringislikeanewbeginning.