简介：AIM:Todeterminethelong-termeffectsofselectivelasertrabeculoplasty(SLT)onintraocularpressure(IOP)andthenumberofmedicationsusedupto5yfollowingtreatmentinglaucomapatientsreceivingmaximallytoleratedmedicaltherapy(MTMT).·METHODS:TheWillsEyeHospitalGlaucomaResearchCenterretrospectivelyreviewedthechartsofglaucomapatientswhounderwentSLTafterreceivingMTMT.Eyesthatdidnotachievetheirtargetpressurewithin3mofollowingSLTwereexcludedfromthestudy.ChangesinmeanIOPandnumberofglaucomamedicationsusedwereanalyzedat1,3,and5yfollowingSLT.·RESULTS:Seventy-fiveeyesof67patientswereincludedinthestudy.FifteeneyesthatreceivedSLTfailedtoachievetheirtargetpressurewithin3moandwereexcludedfromthestudy.Theaveragefollow-uptimewas37.4mo(±14.4).MeanIOPwassignificantlyreduced1yaftertreatment(P=0.005).Itwasalsoreduced3,5yaftertreatmentwithoutreachingstatisticalsignificance(P=0.20andP=0.072,respectively).Therewasasignificantdecreaseinmeannumberofmedicationsused1,3,5yaftertreatment(P<0.001,P<0.001,andP=0.039,respectively).Inthespanof5y,2eyes(2.7%)underwentrepeatSLT,7eyes(9.3%)underwentglaucomasurgeryandanadditional3eyes(4.0%)underwentboth.·CONCLUSION:SLTsignificantlyreducedthenumberofglaucomamedicationsused5yfollowingtreatmentinglaucomapatientsreceivingMTMT.SLTmaydelayoperating-roomsurgery.

简介：AIM:Toevaluatethelongtermclinicalresultsofmechanicalno-alcohol-assistedlaserepithelialkeratomileusis(LASEK)versusstandardphotorefractivekeratectomy(PRK)forlow-moderatemyopia.METHODS:Twenty-fiveeyestreatedwithLASEKandtwenty-fiveeyestreatedwithPRKwereevaluatedwithameanfollow-updurationof60mo.Mechanicalseparationoftheepitheliumwasperformedwithbluntspatulaandwithoutapplicationofalcohol.LaserablationwasperformedwiththeMEL-70excimerlaser.Allpatientswereexamineddailyuntilepithelialclosure;at1,3,6,and12mo,andeveryyearsubsequently.Mainoutcomemeasureswereuncorrecteddistancevisualacuity(UDVA),correcteddistancevisualacuity(CDVA),manifestrefraction,haze,efficacyandsafetyindexes.RESULTS:Twenty-oneeyesand22eyescompletedfollow-upof60moinLASEKandPRKgrouprespectively.Manifestrefractionat60mofollow-upwas-0.01and0.26inLASEKandPRKgrouprespectively.IntheLASEKgroupmeanUDVAandmeanCDVAafter60mowere20/22and20/20respectively(P>0.01).InthePRKgroupmeanUDVAandmeanCDVAat60mofollow-upwere20/20and20/20after60mo(P>0.01).Theefficacyindexeswere0.87and0.95,andthesafetyindexeswere1.25and1.4respectivelyforLASEKgroupandPRKgroup.CONCLUSION:BothstandardPRKandno-alcoholLASEKoffersafeandeffectivecorrectionoflow-moderatemyopiainthelongtermwithoutanystatisticallysignificantdifferencebetweenthetwogroups.