简介:Anumberofpreviousstudiesofacupunctureacupointspecificityhaveusedshamacupoints,shamacupunctureormeridianacupointsatagreatdistancefromeachotherascontrolsinfunctionalMRI(fMRI)experiments.However,fewstudieshavecompareddifferentmeridianacupointswithinthesamesegment,whichareassociatedwithsimilarlyintenseneedlesensations.WeperformedfMRIon12healthyyoungvolunteersandobserveddifferencesinbrainactivationelicitedbyacupunctureoftheTaixi(KI3)andQiuxu(GB40)acupoints.AcupuncturewasappliedattheTaixiandQiuxuacupoints,usingamultiple-blockfMRIdesignwiththreeblocks,involvingthreealternationsofrestingandtaskphases.Afterscanning,needlesensationwasassessed.ThebehavioralresultsrevealedthatthesubjectiveneedlesensationwassimilarbetweentheTaixiandQiuxuacupoints.ThefMRIresultsrevealedthatacupunctureattherightTaixiacupointactivatedtherightsuperiortemporalgyrus(BA22),leftmiddlefrontalgyrus(BA46)andinferiorfrontalgyrus(BA45),bilateralparietallobepostcentralgyrus(BA2),rightparietallobe(BA3),andleftparietallobe(BA40).AcupunctureattherightQiuxuacupointactivatedtheleftsuperiortemporalgyrus(BA42),rightparietallobepostcentralgyrus(BA40,BA43),rightinferiorfrontalgyrus(BA47),bilateralsuperiortemporalgyrus(BA22),andrightinsulaBA13.TheseresultssuggestthattherightTaixiandQiuxuacupointsactivateddifferentbrainareas.
简介:Severalstudieshavedemonstratedthattheamountofbeta-amyloid(Aβ)proteininthebraincanbeloweredbydown-regulatingAβproduction,promotingAβdegradation,reducingAβoligomerizationordeposition,therebyalleviatingsymptomsofAlzheimer'sdisease.Curcuminhasbeenknowntobeaperoxisomeproliferatoractivatedreceptorgamma(PPARγ)agonistandcanobviouslyinhibitAβproductionandoligomerization.Thisstudyinvestigatedtheeffectsofcurcuminontheβ-siteAPPcleavingenzyme1(BACE1)activityandPPARγexpressioninhumanneuroblastomaSH-SY5Ycells,andvalidatedtheinhibitoryeffectsofcurcuminonAβ40/42expressioninthebrain.ResultsrevealedthatPPARγmRNAandproteinexpressioninthehumanneuroblastomaSH-SY5Ycellssignificantlyincreasedwithincreasingcurcuminconcentrationandtimecourse(P<0.05);BACE1mRNAandproteinexpressionandAβ40/42productionsignificantlydecreasedwithincreasingcurcuminconcentrationandtimecourse(P<0.05).ThechangesinPPARγandBACE1expressionduringAβproductioncouldbereversedbythePPARγantagonistGW9662.ThesefindingsindicatethatcurcuminreducedAβproductionbyactivatingPPARγexpressionandinhibitingBACE1expressioninaconcentration-andtime-dependentmanner.
简介:目的研究杏仁核注射β-淀粉样肽(Aβ25-35)所致阿尔茨海默病(AD)模型大鼠脑内Aβ1-40、Bax的表达变化,以及葛根素(Pue)的影响。方法将30只SD大鼠随机分为假手术组、AD模型组和Pue治疗组,以Aβ25-35。右侧杏仁核注射制备大鼠AD模型,用Y-型迷宫检测大鼠学习记忆能力,用免疫组织化学方法检测大脑皮层与海马组织Aβ1-40。和Bax的表达。结果假手术组脑内有Aβ1-40、Bax的少量表达,两者均以皮层内为多,海马组织内少;AD模型组大鼠皮层和海马组织Aβ1-40与Bax的表达增加.较假手术组大鼠有显著性差异.P〈0.01;Pue能改善AD模型组大鼠的学习记忆能力,Pue治疗组大鼠皮层和海马组织Aβ1-40、Bax表达减少,与AD模型组比较有显著性差异,P〈0.05。结论Pue可能通过下调脑组织Aβ1-40和Bax表达,抑制β-淀粉样肽的神经毒性,减轻脑皮层和海马神经元凋亡.具有神经保护及抗痴呆作用。
简介:目的:探讨腹腔镜下子宫-阴道骶骨固定术(HY+CSP)治疗中重度盆腔器官脱垂(POP)的安全性、疗效以及并发症。方法:回顾性分析2014年1月至2016年1月我院收治的应用的腹腔镜阴道骶骨固定术(HY+CSP)治疗的POP患者40例,对患者手术前后的POP-Q评分、PISQ评分、PSQI评分予以分析。结果:患者术后盆腔各位点与术前相比较,差异有统计学意义(P〈0.05);术后12个月PSQI评分低于术前,差异有统计学意义(P〈0.05);术后6个月、12个月PISQ评分均高于术前,差异有统计学意义(P〈0.05)。结论:腹腔镜阴道-子宫骶骨固定术可有效恢复POP患者阴道正常解剖位置,治疗效果良好,可有效改善患者的生命质量、睡眠质量,值得推广使用。
简介:目的了解北京市朝阳区八里庄地区40岁以上人群脑卒中危险因素、暴露水平及其人群分布特征。方法研究为横断面调查研究,以年龄≥40岁的人群作为研究对象,采取整群抽样方法,对8888例研究对象采用统一问卷调查和体格检查,通过统一的脑卒中风险评估表进行脑卒中风险评估;对初步筛查为高危人群的研究对象进行体格检查和实验室检查。结果经过脑卒中风险评估,低危5622例(63.25%),中危1537例(17.29%),高危1729例(19.45%)。研究对象男性平均年龄为62.1±13.2岁,女性60.2±12.2岁。在40~69岁年龄段,高血压病、心房颤动或瓣膜性心脏病、糖尿病、明显超重等因素呈现随年龄增长而增加的趋势;而吸烟率则呈现随年龄增长而降低的趋势。〈50岁组的人群体力活动量最少519(28%)。高危人群中男性453例(26.20%),女性1276例(73.80%)。男性吸烟率(41.9%)显著高于女性(5.6%);血脂异常率、卒中家族史因素女性高于男性,差异有统计学显著意义(P均〈0.05),人群中具有一个危险因素的比例最高为3397例(53.63%),具有4个以上危险因素者643例(10.15%)。结论八里庄地区≥40岁人群中,脑卒中危险因素整体水平较高;高血压病、心房颤动或瓣膜性心脏病、糖尿病等因素在40~70岁年龄段内,呈现增加趋势;高危人群中,高血压病、血脂异常、卒中家族史为人数分布前三位的危险因素。
简介:目的探讨脑多巴胺转运体(DAT)^99Tc^m-TRODAT-1SPECT显像与多巴胺D2受体(D2R)^131I-epideprideSPECT显像在早期帕金森病(PD)中的临床应用价值。方法10例正常对照者及46例早期未经替代治疗的PD患者分别接受脑DAT^99Tc^m-TRODAT-1SPECT与多巴胺D2R^131I-epideprideSPECT断层显像,利用感兴趣区技术计算纹状体与枕叶、额叶的放射性比值(ST-OC/OC和ST-FC/FC)。结果PD患者起病肢体对侧脑DAT比值ST-OC/OC和ST-FC/FC比同侧均降低,双侧ST-OC/OC较对照组均降低。PD患者起病肢体对侧脑D2R比值ST-OC/OC和ST-FC/FC比同侧均增高。PD患者起病肢体对侧脑DAT比值ST-OC/OC与患者病程呈负相关,起病肢体对侧脑D2R比值ST-OC/OC与患者年龄及UPDRS运动评分呈负相关。结论人脑DAT^99Tc^m-TRODAT-1SPECT显像与D2R^131I-epideprideSPECT显像均有助于PD的早期诊断及病情监测。
简介:Thisstudyadaptedastatisticalprobabilisticanatomicalmapofthebrainforsinglephotonemissioncomputedtomographyimagesofdepressiveend-stagerenaldiseasepatients.Thisresearchaimedtoinvestigatetherelationshipbetweensymptomclusters,diseaseseverity,andcerebralbloodflow.Twenty-sevenpatients(16males,11females)withstages4and5end-stagerenaldiseasewereenrolled,alongwith25healthycontrols.Allpatientsunderwentdepressivemoodassessmentandbrainsinglephotonemissioncomputedtomography.Thestatisticalprobabilisticanatomicalmapimageswereusedtocalculatethebrainsinglephotonemissioncomputedtomographycounts.AsymmetricindexwasacquiredandPearsoncorrelationanalysiswasperformedtoanalyzethecorrelationbetweensymptomfactors,severity,andregionalcerebralbloodflow.ThedepressionfactorsoftheHamiltonDepressionRatingScaleshowedanegativecorrelationwithcerebralbloodflowintheleftamygdale.Theinsomniafactorshowednegativecorrelationswithcerebralbloodflowintheleftamygdala,rightsuperiorfrontalgyrus,rightmiddlefrontalgyrus,andleftmiddlefrontalgyrus.Theanxietyfactorshowedapositivecorrelationwithcerebralglucosemetabolisminthecerebellarvermisandanegativecorrelationwithcerebralglucosemetabolismintheleftglobuspallidus,rightinferiorfrontalgyrus,bothtemporalpoles,andleftparahippocampus.Theoveralldepressionseverity(totalscoresofHamiltonDepressionRatingScale)wasnegativelycorrelatedwiththestatisticalprobabilisticanatomicalmapresultsintheleftamygdalaandrightinferiorfrontalgyrus.Inconclusion,ourresultsdemonstratedthatthediseaseseverityandextentofcerebralbloodflowquantifiedbyaprobabilisticbrainatlaswasrelatedtovariousbrainareasintermsoftheoverallseverityandsymptomfactorsinend-stagerenaldiseasepatients.