简介：新奇的碳基于强壮的稳固的酸催化剂成功地被综合了。为acetalization和ketalization的催化活动被调查。结果证明新奇催化剂与超过92%的平均收益是很有效的。新奇异构的催化剂也有高活动，甚至到7membered戒指缩荃和ketals的准备的宽适用性，惊人地简单的workup过程，非污染和可重用性的优点，它将极大地贡献绿过程。

简介：一系列新奇1,3,4-thiadiazole衍生物被CCK-8试金对人的肝癌症房间SSMC-7721，人的乳癌房间MCF-7和人的肺癌症房间A549在vitro为他们的cytotoxicity基于benzisoselenazolone综合并且评估。结果证明混合物7e，7f，7h，7k，7l和7m对MCF-7房间线显示了好cytotoxicity。复合7l在测试混合物之中展出了大多数有势力antitumor活动。

简介：Tetradecyldimethylbenzylammoniumsalt(TDMBA)cationswereintercalatedintosodiummontmorillonite(Na-MMT)byanionexchangereaction.TheresultingTDMBA-MMTwascharacterizedbyFourier-transforminfraredspectroscopy(FTIR),thermogravimetricanalysis(TGA),andX-raydiffraction(XRD).Moreover,theantibacterialactivityandwater-resistanceofTDMBA-MMTwereinvestigated.TheresultsshowthatTDMBAcationsareintercalatedintotheNa-MMT.TheonsettemperatureofdecompositionofTDMBAcationsinTDMBA-MMTisraisedabout60℃higherthanthatoftetradecyldimethylbenzylammoniumchloride(TDMBACl),andthed_((001))spacingenlargedfrom1.23nmto2.10nm.0.1mg/mLTDMBA-MMTisfullyenoughtokillalltheStaphylococciaureus(S.aureus)andmorethan99.99%oftheEscherichiacoli(E.coli)inasamplesolutionwithin6.0htouch,andtheTDMBA-MMTalsoshowslongactingproperties.

简介：Thesixmultiimidazolecopper(Ⅰ)complexesareutilizedtomimictyrosinase.Themainproductis3,5-di-t-butylcatecholfromo-hydroxylationofthesubstrate2,4-di-t-butylphenol.Thehighestyieldofcatecholisupto82.2%andselectivity94.8%by[Cu(I)_(3b)(MeCN)_2](ClO_4)_2andO_2undermildconditions,whicharefoundtobemoreefficientthanthatalreadyreported.

简介：在allosteric酶和底层之间的有约束力的过程上的使活跃之物分子和压抑的分子的效果被考虑绑在allosteric酶的调整分子的heterotropic效果讨论。有heterotropic效果的allosteric酶的一个模型被介绍。在规定过程的cooperativity和anticooperativity被学习。

简介：Inordertocreateanewmimicofglutathioneperoxidase(GPx),bioimprintingwasusedtogenerategluta-thione(GSH)bindingsiteandchemicalmodificationwasusedtoincorporatecatalyticgroupselenocystine(Sec).Humanserumalbumin(HSA)andS-substituteddinitrophenylglutathione(GSH-S-DNP)werechosenastheimprintedmatrixandimprintingtemplate,respectively,togenerateaGSH-imprintedprotein(GSH-HSA)bybioimprinting.SecwasincorporatedintotheGSH-HSAbychemicalmodificationtogiveanewGPxmimic(Se-GSH-HSA).Se-GSH-HSAdisplayedconsiderablyhigherGPxactivitythannon-printedHSA(Se-HSA).TheenzymicpropertiesandkineticsofSe-GSH-HSAwerestudied.Moreover,Se-GSH-HSAwasconfirmedtohavestrongerantioxidantabilitytoprotectmitochondriaagainstoxidativedamagewithferroussulfate/ascorbate-inducedmitochondriadamagemodel,indicatingthatSe-GSH-HSAhaspotentialapplicationinmedicine.

简介：Fivenewcephalosporincompoundsweredesignedandsynthesized,andtheantibacterialactivitieswereevaluatedbythestandardserial2-foldagardilutionmethodinvitro.TheresultsshowedthattheactivitiesofthecompoundsⅠaandⅠbagainstESBLE.coliandK.pneumoniaearecomparabletothoseofCefepime.

简介：Tostudytheeffectofthesugarchainsinglycoalkaloidsagainstcancercells,6-O-sulfatedsolamargineandacid-catalyzedhydrolyticproductsofα-solamargineandα-solasoninewereprepared.ThesulfationatO-6ofsolamarginewasproceededinfivesteps.The6-OHgroupwasfirstselectivelyprotectedwithDMT-Cl,andthenthesecondaryhydroxylgroupsonthesugarringwereacetylated.AftertheprotectivegroupDMTrwasremoved,thefree6-OHgroupwassulfated.Finally,theacetylgroupswereremovedtogive6-O-sulfatedsolamargineinagoodyield.Thehydrolysesofsolamargineandsolasoninewereperformedindilutedhydrogenchlorede.Threeandtwohydrolyzedproductswereobtainedfromsolamargineandsolasonine,respectively.TheantiproliferativeactivitiesagainstHCT-8tumorcellsoftwoglycoalkaloidsandtheirderivatieswereexaminedviaaMTTassay.Theresultsshowthatα-solamargineandα-solasonineexhibitstrongcytotoxicactivitieswithanIC50of10.63and11.97μmol/L,respectively,wherastheirderivatiesseemtobelessactivities.

简介：一系列新与酉分的抗氧化剂消炎痛结合为提高的antiinflammatory被综合活动以及减少的ulcerogenic力量。都结合，这被发现很在vitro的有势力抗氧化剂。他们能显著地禁止类脂化合物peroxidation，当11b11e和13b13e能也与DPPH交往时。然而这些对巴豆油结合显示出的小抑制导致的老鼠耳朵胀大。

简介：Solasodine11是有各种各样的生物活动的steroidal碱。此处，8新奇solasodine衍生物被综合，他们前列腺癌症房间增长上的效果在vitro被估计。在antiproliferative活动的重要改进在一些合成类似物之中被完成。特别地，19展出了大多数有势力对PC-3房间线的增长的禁止的效果(IC50=3.91渭mol/L)。

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简介：Sulfonylureaherbicideshavebeenwidelyusedbecauseoftheirlowapplicationrates,goodcropselectivitiesandlowmammaliantoxicities.However,somesulfonylureasmightpersistunfavourablyintheenvironmentwithresidualproblems.Inordertolookforecologicallysaferandenvironmentallybenignsulfonylureas,andonkeepingthepyrimidineringbeingmonosubstituted,15novelC5-monosubstitutedbenzenesulfonylureacompoundsweresynthesized.Thestructuresofallthecompoundssynthesizedwereconfirmedbyelementalanalysisand1HNMR.PreliminaryherbicidalactivitiesofthesenewsulfonylureacompoundsweredeterminedbyALSscreening(invitro)andpotbioassayexperiments(invivo).TheherbicidalresultsshowthatsomenovelsulfonylureasarecomparabletocommercialForamsulfuronandMonosulfuron.

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简介：Fivebenzamidederiativescontainingcapsaicinweresynthesizedwhichhavesimilarstructurestocapsaicin.Theiryieldwashigh.ThemonomerssynthesizedwerecharacterizedbyIR,1HNMRandMSspectroscopy.Cha-racterizationdataareinagreementwiththeproposedstructuresoftheproducts.ThesefivecompoundsexhibitbacterialinhibitionandN-[4-hydroxy-2-methyl-5-(methylthio)benzyl]benzamide(HMMBBA),forinstance,showsthattheminimalinhibitoryconcentrations(MIC)ofHMMBBAare0.125and0.25mg/mLonStaphyloccocusaureusandEscherichiacoli,respectively.Astatictestsitewassetupintheeighthharbortoinvestigatetheantifoulingeffectivenessofthefivenewantifoulants.Five-monthexposureexperimentswereperformedonsetsofpanelscoatedwitheachofantifoulingcoatings,andtheresultswerecomparedtothatofthetestpanelwithoutantifoulingcoating.TestboardswithantifoulingcoatingwerecoveredwithjustamacroscopicfoulingorganismsuchasBalanus.Theresultsofthepresentpaperdemonstratethatnewantifoulantsrepresentanalternativetothebiocidalantifoulingpaint.

简介：EachofKeggintypeheteropolytungstosilicicandheteropolytungstogermanicacidsreactedwith8-quinolinol,p-aminodimethylanilineandpyridine,respectively,yieldingsixchargetransferheteropolycomplexes(CTHPCs),whichwerepurifiedandcharacterizedbyelementalanalysis,IR,UVand183WNMR.Theanti-HIV-1activitiesofCTHPCswereevaluatedbyELISAofHIV-P24antigen.ThetoxicityagainstMT-4cellswasmeasuredbyMTT.Theresultsshowthatmedianinhibitoryconcentration(IC50)foreachCTHPCtoinhibitHIV-P24antigenincellculturewaslowerthan5μg/mL,whilemediantoxicityconcentration(IC50)againstMT-4cellswashigherthan268μg/mL.Thefollowingmechanismsmightbeconsideredfortheiranti-HIV1activity,namely,(1)inhibitingthepenetrationofHIV-1virusintotargetcellsforitcanblockadeCD4receptorofMT-4cellsand(2)inhibitionofsyncytiumformation.

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简介：Thymopentinderivative(septapeptide)waspreparedbymeansofthesolid-phasepeptidesynthesismethodinwhichstepwiseandsegmentcondensationswereinvolved.ThestructuresofthekeyintermediateandtargetmoleculewereconfirmedbyESI-MS,elementaryanalysis,IR,1HNMRand13CNMRspectrometriesinourexperiments.Inthisstudy,theauthorsfoundthatboththymopentinderivetive(septapeptide)andthymopentincouldpromoteTcellproliferationandincreaseofE-rosefomationcells.

简介：一系列新奇phthalimides对七phytopathogenic真菌在vitro为抗真菌的活动作好准备并且测试:Rhizoctoniasolani，镰刀霉oxysporumf.sp。cucumerinum欧文，Botrytiscinerea，Fulviafulva，SclerotiniasclerotiorumdeBary，Phytophthoracapsici，Botryosphaeriaberengeriama。结果证明保持6-methylpyridin-2-yl的结构的那些混合物对Phytophthoracapsici和Botrytiscinerea展出了好活动。

简介：PolysiliconMicroelectromechanicalsystems(MEMS)arethesubjectofintensiveresearches.SurfacechemistryandtopographyofaMEMSteststructurefabricatedatSandiaNationalLaboratory,USA,werestudiedbymeansofscanningelectronmicroscopy(SEM),X-rayphotoelectronspectroscopy(XPS)andatomicforcemicroscopy(AFM).XPSC()andSi2,spectrafromthepolysilieoncomponents,siliconnitridesubstrateandareferencesiliconwaferwerecompared.Theresultsconfirmthepresenceofaself-assembledmonolayer(SAM)ontheMEMSsurface.Anisland-likemorphologywasfoundonbothpolysiliconandsiliconnitridesurfacesoftheMEMS.Theislandstaketheformofcaps,beingupto0.5μmindiameterand20nminheight.Itisconcludedthattheco-existenceofcolumnargrowthandequiaxedgrowthduringthelowpressurechemicalvapordeposition(LPCVD)oftheselayersleadstotheobservedmorphologyandtheislandsarecapstothecolumnarstructures.

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