简介:Traumaticinjuriestospinalcordelicitdiversesignalingpathwaysleadingtounselectiveandcomplexpathologicaloutcomes:deathofmultipleclassesofneuralcells,formationofcysticcavitiesandglialscars,disruptionofaxonalconnections,anddemyelinationofsparedaxons,allofwhichcancontributemoreorlesstodebilitatingfunctionalimpairmentsfoundinpatientswithspinal
简介:Inthispaper,acontrolintegrationmethodbasedonagentcooperation,calledASOJI,isproposed,whichdesignsthearchitectureofintegratedapplicationsystemsindistributedcomputationenvironmentsasanagentcommunitycomposedofnestedagentfed-erationsinthreeaspects:architecturestyle,agentcooperation,andcompositionsemantics.Throughdefiningactivity-sharing-orentedjointintentioninthewayofstepwiserefinement,ASOJIcannotonlysupportthetransparentspecificationofthearchitectureforsoftwarecom-position,butalsoeliminatethegapbetweenagenttheoryandtheengineeringrealiztionofcontrolintegration.
简介:Giventherisingtrendinobesityinchildrenandyouthandage-relateddeclineinmoderate-to-vigorous-intensityphysicalactivity(MVPA)inseveralWestern,African,andAsian-Pacificcountries~1andstrongevidencethatpastphysicalactivity(PA)interventionshavehadonlyasmalleffectonchildren’sandyouth’soverallactivitylevels,~2itisimportanttoclarifywhetherschool-basedPAinterventionswarrantresourceallocation.Schoolsrepresentanaccessibleandcost-effectivesetting
简介:重要信息指差错运动(例如,差错活动时期,紧张,频率,和甚至有活力的背景)当渗出或磨擦时,能被解决差错凿揭示,它是差错运动的结果。地调查包含了样品从QinlingOrogenic带(QOB)的西方的片断的Bailong河差错系统收集;差错凿的44件样品为石英被收集微形态学的分析。这些样品用扫描电子显微镜学的地排放被分析。另外,14件样品为标明日期的热照明被测试。结果证明大多数石英谷物的表面质地被鱼规模,像苔藓的质地,和钟乳石描绘。然而,像皮的破裂和worm-hole-like塑造了的橘子的小数量表面质地被观察。而且,在石英谷物的一些典型conchoids或subconchoidal破裂能被看见。这暗示Bailong河差错在第四级的时期期间反复是活跃的,但是主要运动时期是更新世。标明日期价值的14热照明显示出二个年龄组:343.29-184.06ka和92.18-13.87ka。这些学习数据表明那个差错运动在上新世期间开始了,在更新世的早中间的时期经常发生了,并且运动的山峰频率在早更新世被到达。差错运动被停止在早Holocene终止了。结果为在QOB的西方的片断的自然灾难风险评估是重要的。
简介:在cis的第二上的一个部件的transcriptional活动的直接否定的影响被叫作transcriptional干扰(TI)。U6是通常使用在基于向量的RNAi驾驶小发卡RNA(shRNA)表示的一个类型IIIRNA聚合酶III倡导者。在病毒的向量的设计和构造,多重抄写单位可以在空间有限向量在靠近的最近被安排。决定U6倡导者活动是否能被TI影响为在基因治疗的目标shRNA的表示是批评的或loss-of-function学习。在这研究,我们设计了并且实现shRNA和外长的基因表情由二个独立transcriptional单位被驾驶的一个修改retroviral系统。我们安排了在二倡导者安排驾驶shRNA表示和UbiC倡导者的U6倡导者。在主要巨噬细胞,我们发现U6倡导者活动被UbiC倡导者禁止什么时候在分叉的安排然而并非在双人脚踏车。相反,PKG倡导者没有如此的否定影响。而不是提高U6倡导者活动,CMVenhancer面对UbiC倡导者在U6倡导者活动有重要否定影响。我们的结果显示那项U6倡导者活动能被TI影响在一近似倡导者特定并且安排依赖者举止。
简介:Inthispaper,wemadeasystematicstudyonmorethan40yearsofobservationaldataoftentemporaryfault-crossingmeasurementsitesinthecapitalcircleregionofChina.Wecalculatedhorizontalandvertica1componentsoffaultslip,andhorizontalextensionorcompressioncomponents.Consideringthetectoniccharacteristicsofthecapitalcircleregionandregionalseismicity,weanalyzedthepresentfaultactivityofthecapitalcircleregionandtherelationshipwithearthquakes.Theresultsshowthecomplexityoffaultactivityintheregion:thelevelofactivityofallfaultsislow,mostfaultsareleft-lateralstrike-slipfaults;thereislessverticalactivitythanhorizontalactivityandcrustalmovementiscontrolledbyhorizontalmovement;faultactivityandearthquakeactivityhaveacertainrelationship,regionalfaultactivityincreasesbeforeanearthquake,andfaultactivityhascertainabnormalfeaturesbeforestrongearthquakes.