简介：AbstractThe global spread of SARS-CoV-2 is currently continuing, and the World Health Organization has announced the risk assessment of the viruses as high. In this study, we analyzed virology features of SARS-CoV-2 causing a family cluster outbreak. Among the six family members, five have been laboratory-confirmed infection of SARS-CoV-2 viruses. A total of five SARS-CoV-2 viruses have been isolated from the nasopharyngeal swabs. The complete genome of the viruses exhibited 100% nucleotide identity with each other. Only two nucleotide differences have been observed between genomes of the isolated viruses and the HCoV/Wuhan/IVDC-HB-01/2019 strain. Therefore, SARS-CoV-2 has been confirmed as the causation of the family cluster infections.

简介：AccordingtonewsfromthewebsiteofNationalHealthandFamilyPlanningCommission(NHFPC)onApril17,MinistryofFinanceandNHFPCrecentlyissuedOpinionsonFurtherImprovingtheInputMechanisminFamilyPlanning,toimprovethesystemofspecialsubsidy

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简介：在谷物的含纤维的根系统包括首先偶然根(艺术)，它在营养素和水举起起重要作用。关于位于AR开发下面的分子的机制的当前的知识仍然是有限的。我们这里报导四米饭(OryzasativaL.)的隔离异种从不同基因背景，所有哪个在AR是有缺点的形成。这些异种展出了侧面的根(LR)和gravitropism的部分损失的减少的数字。也显示的异种提高了敏感到N-1-naphthylphthalamic酸，极的植物生长素运输的一个禁止者(轻拍)，显示变化影响了植物生长素运输。用四异种之一的位置的克隆表明它被一个guanine核苷酸交换因素的loss-of-function为ADP-ribosylation因素(OsGNOM1)引起。转基因的植物显示出的promoter::GUS的RT-PCR和分析那OsGNOM1在ARprimordia，脉管的纸巾，LR，根尖端，叶子，花药和词根静脉被表示，与类似于植物生长素的一个分发模式。另外，OsPIN2，OsPIN5b和OsPIN9的表情在异种被改变。一起拿，这些调查结果显示OsGNOM1通过调整影响艺术的形成轻拍。

简介：On2016March24,NationalHealthandFamilyPlanningCommission(NHFPC)heldtheleadinggroupmeetingonpovertyalleviationandpairing-assistance,whichplannedtheimplementationof2016healthandpovertyalleviationproject.LiBin,thegroupleaderandministerofNHFPC,

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简介：ThebiggestmassmigrationinhumanhistoryiscurrentlyunderwayinChina.Populationmovementandmigrationplayaleadingroleinthetransformationofurbanandruralpopulationstructureandareaffectingtheevolutionofbothpopulationsizeandstructureofvariousregions.Togranturbanresidencytomigrantsisatopprior-

简介：TheconvergenceproblemofthefamilyofEuler-HalleymethodsisconsideredundertheLipschitzconditionwiththeL-average,andaunitedconvergencetheorywithitsapplicationsispresented.

简介：AbstractObjectives:Hearing loss is a worldwide disease. In 50% of the patients, hearing loss is caused by genetic problems associated with GJB2, MTRNR1, SLC26A4, and other genes. Considering the recent development and cost reduction of whole-exome sequencing, it is possible to filter out the normal genes and find which among the more novel genes contributed to the loss of hearing.Methods:After prescreening all individuals for GJB2, MTRNR1 and SLC26A4 mutations, whole-exome sequencing was performed in the proband, and the pathogenic variant was confirmed via Sanger sequencing.Results:The compound-heterozygous variant namely c.8076G>C:p.E2692D and c.6362T>C:p.V2121A in OTOG was identified as a candidate gene of a consanguineous Kazakh family.Conclusion:This is the first reported case of severe deafness caused by an OTOG compound-heterozygous variant in the world and the first case of deafness caused by an OTOG variant in China. This discovery identified the important contribution of OTOG toward deafness and expanded the spectrum of variants responsible for human hearing loss.

简介：ByusingtheperturbationresultsofsumsofrangesofaccretivemappingsofCalvertandGupta(1978),theabstractresultsontheexistenceofsolutionsofafamilyofnonlinearboundaryvalueproblemsinL^2(Ω)arestudied.TheequationdiscussedinthispaperandthemethodsusedhereareextensionandcomplementtothecorrespondingresultsofWeiLiandHeZhen'spreviouspapers.Especially,somenewtechniquesareusedinthispaper.

简介：《德伯家的苔丝》是托马斯·哈代的代表作之一。它描写了一个美丽、天真、勤劳的农家姑娘苔丝的悲剧一生。通常苔丝的悲剧被归结为社会的影响,即资本主义入侵带来的小农经济的解体以及针对女性的不公正道德标准。本文将深入分析社会意识力量,聚焦造成苔丝悲剧的错误、不公正的社会观点。揭示出父权社会中苔丝不可避免成为婚姻和家庭的牺牲品,同时也突出了小说的女性主义主题。

简介：Quantileregressionisgraduallyemergingasapowerfultoolforestimatingmodelsofconditionalquantilefunctions,andthereforeresearchinthisareahasvastlyincreasedinthepasttwodecades.Thispaper,withthequantileregressiontechnique,isthefirstcomprehensivelongitudinalstudyonmathematicsparticipationdatacollectedinAlberta,Canada.Themajoradvantageoflongitudinalstudyisitscapabilitytoseparatetheso-calledcohortandageeffectsinthecontextofpopulationstudies.Oneaimofthispaperistostudywhetherthefamilybackgroundfactorsalterperformanceonthemathematicalachievementofthestrongeststudentsinthesamewayasthatofweakerstudentsbasedonthelargelongitudinalsampleof2000,2001and2002mathematicsparticipationlongitudinaldataset.Theinterestingfindingssuggestthattheremaybedifferentialfamilybackgroundfactoreffectsatdifferentpointsinthemathematicalachievementconditionaldistribution.

简介：ForagiventriangulationΔofaregionRofinterest,letS82（Δ）:={s∈C2（R）:s|1∈P8,l∈Δ}bethespaceofallsplinesofdegree8andsmoothness2,wheretdenotesanytriangleofΔandP8thespaceofpolynomialsoftotaldegree≤8.Furthermore,letS82（Δ）:={s∈S83（Δ）:s∈C3atv,v∈Δ}beasupersplinesubspaceofS82（Δ）.WeconstruelacollectionoflocallysupportedsplinesinS82（Δ）whichcanbeusedtoachievelhefullapproximationorderofS82（Δ）anditscardinalilyislessthanthedi-mensionofsupersplinespacespaceS82（Δ）.

简介：Colorectalcancer(CRC)isthethirdmostcommoncancerinmenandthesecondmostcommoncancerinwomen,worldwide.Intheearlystagesofthedisease,biomarkerspredictingearlyrelapsewouldimprovesurvivalrates.Inmetastaticpatients,theuseofpredictivebiomarkerscouldpotentiallyresultinmorepersonalizedtreatmentsandbetteroutcomes.TheCXCfamilyofchemokines(CXCL1to17)aresmall(8to10kDa)secretedproteinsthatattractneutrophilsandlymphocytes.Thesechemokinessignalthroughchemokinereceptors(CXCR)1to8.Severalstudieshavereportedthatthesechemokinesandreceptorshavearoleineitherthepromotionorinhibitionofcancer,dependingontheircapacitytosuppressorstimulatetheactionoftheimmunesystem,respectively.Ingeneralterms,activationoftheCXCR1/CXCR2pathwayortheCXCR4/CXCR7pathwayisassociatedwithtumoraggressivenessandpoorprognosis;therefore,thespecificinhibitionofthesereceptorsisapossibletherapeuticstrategy.Ontheotherhand,thelesserknownCXCR3andCXCR5axesaregenerallyconsideredtobetumorsuppressorsignalingpathways,andtheirstimulationhasbeensuggestedasawaytofightcancer.Thesepathwayshavebeenstudiedintumortissues(usingimmunohistochemistryormeasuringmRNAlevels)orserum[usingenzyme-linkedimmunosorbentassay(ELISA)ormultiplexingtechniques],amongothersampletypes.CommonvariantsingenesencodingfortheCXCchemokineshavealsobeeninvestigatedaspossiblebiomarkersofthedisease.ThisreviewsummarizesthemostrecentfindingsontheroleofCXCchemokinesandtheirreceptorsinCRCanddiscussestheirpossiblevalueasprognosticorpredictivebiomarkersaswellasthepossibilityoftargetingthemasatherapeuticstrategy.

简介：NationalTeleconferenceonFamilyPlanningWorkwasheldinBeijingonFebruary27,2014.LiKeqiang,MemberoftheStandingCommitteeofCPCCentralCommitteePoliticalBureauandPremieroftheStateCouncilmadeimportantinstructions,'Adjustingandimprovingfertilitypolicies

简介：SincetheestablishmentofthenewChinese,familyplanningpolicyinourcountryhasexperiencedthedevelopmentcourseofwavetype.Wefoundthatchangesinfertilitypolicyalongwiththecontinuousadjustmentofsocialmechanism,fromthe1950smainlybyadministrativeplanandcontrolmode,graduallytothe1990smainlybyguide-serviceandsecuritymode.Thecurrentfertilitypolicy,leapthelimitationsofpureadministrativeorders,underthecareofsocialmechanism,softentheinstitutionalpowersingleimpliedinthewholesocialframework,throughthepowersystemofmultilevel,reconcilethegapbetweennationalpopulationawarenessandindividualreproductivebehavior,providetheharmoniousstrengthforpopulationdevelopment.

简介：In2012,inaccordancewiththedecisionsandplansofthePartyCentralCommitteeandtheStateCouncil,healthandfamilyplanningdepartmentsatalllevelshadacceleratedtheestablishmentandimprovementofnationalmedicalinsurancesystem,reinforcedandimprovedthebasicdrugsystemandthenewoperationalmechanismforgrass-roots;orderlypromotedreformonpublichospitalsandmadeeffortstoimprovemedicalandhealthservices;putfortheffortstostrengthentheprevention

简介：Membersoftheactivityofbc1complex(ABC1)familyareproteinkinasesthatarewidelyfoundinprokaryotesandeukaryotes.PreviousstudiesshowedthatseveralplantABC1genesparticipatedintheabioticstressresponse.Here,wepresentthesystematicidentificationofriceandArabidopsisABC1genesandtheexpressionanalysisofriceABC1genes.Atotalof15and17ABC1genesfromthericeandArabidopsisgenomes,respectively,wereidentifiedusingabioinformaticsapproach.Phylogeneticanalyseso...