简介：AbstractAtopic dermatitis (AD) is a chronic inflammatory skin disease with xerosis, itchiness, as well as interconnection with immunoglobulin E (Ig E), mediated foods including airborne allergies. AD is not only related to the diminished stratum corneum barrier but also presents with an unusual expression of tight junctions (TJs) proteins. TJ barrier dysfunction leads to impairment in the stratum corneum (SC) barrier. The significant role of TJs in the epidermal barrier as indicated by Claudin-1 (Cldn-1) deficient mice that undergo high transepidermal water loss (TEWL) and skin dehydration. In atopic dermatitis, downregulation of Cldn-1 was observed due to inflammation. Still, a lack of distinct understanding exists in considering tight junction barrier impairment as a cause or outcome in atopic dermatitis. This review summarizes TJs main role in skin barrier function and TJ proteins (TJPs) expression observed in AD patients.

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简介：在这篇论文，超导的顺序参数和Bogoliubov刺激的精力光谱为铁磁性的超导体(FS)从Bogoliubov-deGennes(BdG)方程被获得。考虑散布效果的不平的接口，我们计算射击噪音和正常金属的绝缘体的微分传导力铁磁性的超导体连接。在FS的交换精力E_h能导致微分射击噪音山峰和传导力山峰切开，这被显示出。二座切开的山峰之间的精力差别等于2E_h。散布力量的不平的接口导致传导力山峰和射击noise-to-current比率的降下，但是增加射击噪音。

简介：<正>来自市场研究机构FutureHorizons的知名分析师MalcolmPenn表示,半导体制造商们的心态已经因为某些因素而改变,他们不再兴建新晶圆厂来因应预期中的需求;他在一场预测2011年市场前景的专题演说中指出:"忘了"轻晶圆厂(fab-lite)"这个名词吧,欢迎来到"晶圆厂产能吃紧(fab-tight)"的时代!"

简介：Carbonnanotubeswithjunctionsmayplayanimportantroleinfuturenanoelectronicsandfuturenanodevices.Inparticular,junctionsconstructedwithmetalandsemiconductingnanotubeshavepotentialapplications.Basedontheorthogonaltight-bindingmoleculardynamicsmethod,wepresentourstudyofthestructurestabilityofI-typecarbonnanotubejunctions.

简介：Tightfocusingofaxiallysymmetricpolarizedvortexbeamsisstudiednumericallybasedonvectordiffractiontheory.Themathematicalexpressionsforthefocusedfieldsarederived.Simulationresultsshowthatthefocusedfieldsandphasedistributionsatfocusarelargelyinfluencedbyboththepolarizationorderandtopologicalchargeoftheincidentbeams.Moreover,focalspotswithflat-toppedortightly-focusedpatternscanbeflexiblyachievedbycarefullychoosingthepolarizationorderandthetopologicalcharge,whichconfirmsthepotentialofsuchbeamsinwideapplications,suchasopticaltweezers,laserprinting,lithography,andmaterialprocessing.

简介：Inthisarticle,weintroduceanotionofnonuniformwaveletframesonlocalfieldsofpositivecharacteristic.Furthermore,wegaveacompletecharacterizationoftightnonuniformwaveletframesonlocalfieldsofpositivecharacteristicviaFouriertransform.OurresultsalsoholdfortheCantordyadicgroupandtheVilenkingroupsastheyarelocalfieldsofpositivecharacteristic.

简介：三个男人，或因为工作．或因为私人原因，分别来到了几个城市，繁华或者朴实，忙碌或者悠闲．在旅行的名义下．懂得人生的意义。

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简介：TheelectricalnonlinearityofsiliconmodulatorsbasedonreversedPNjunctionswasfoundtoseverelylimitthelinearityofthemodulators.Thiseffect,however,wasinadvertentlyneglectedinpreviousstudies.Consideringtheelectricalnonlinearityinsimulation,a32.2dBdegradationintheCDR3(i.e.,thesuppressionratiobetweenthefundamentalsignalandintermodulationdistortion)ofthemodulatorwasobservedatamodulationspeedof12GHz,andthespuriousfreedynamicrangewassimultaneouslydegradedby17.4dB.ItwasalsofoundthatthelinearityofthesiliconmodulatorcouldbeimprovedbyreducingtheseriesresistanceofthePNjunction.Thefrequencydependenceofthelinearityduetotheelectricalnonlinearitywasalsoinvestigated.

简介：AKondomodelinasquaretight-bondinglatticeofconductionelectronsisconsidered.TheKondointeractiontakesad-wave.Usingmean-fieldtheoryandnumericalsimulations,itisfoundthatthereisapseudo-gapfortheimpuritydensityofstatesattheFermilevel.Numericalresultsalsoshowthattheexponentsofthelowtemperaturethermodynamicquantitiesarenon-universalbutdependentontheinteraction.

简介：摘要目的比较Tight Rope联合锚钉固定与单纯Tight Rope固定治疗重度肩锁关节脱位的临床效果。方法回顾性研究。纳入2017年4月—2020年12月南京医科大学附属逸夫医院骨科收治的45例重度肩锁关节脱位患者临床资料，其中男30例、女15例，年龄25～61（47.8±10.5）岁。按照Rockwood分型：Ⅳ型31例，Ⅴ型14例。根据患者手术方法不同分为2组，采用Tight Rope联合锚钉固定治疗25例为Tight Rope+锚钉组，其中男17例、女8例，年龄25～60（48.1±9.9）岁；采用单纯Tight Rope固定治疗20例为Tight Rope组，其中男14例、女6例，年龄27～61（47.4±10.8）岁。比较2组患者临床基线资料、手术切口长度、手术时间、住院时间，以及术后伤口感染、关节活动受限、内固定松动等并发症发生情况。术后3个月，采用疼痛视觉模拟评分法（VAS）评价患肢疼痛程度，应用Constant-Murley评分（CMS）、美国加州大学洛杉矶分校（UCLA）肩关节评分系统评价肩关节功能；同时拍摄肩关节正位及改良Alexander位X线片，评定锁骨的垂直稳定程度和水平稳定程度。结果2组患者年龄、性别、受伤部位、受伤原因、受伤至手术时间等基线资料比较差异均无统计学意义（P值均>0.05）。2组患者均顺利完成手术，术中无相关并发症发生。2组手术切口长度、手术时间、住院时间差异均无统计学意义（P值均>0.05）。Tight Rope+锚钉组1例患者术后出现切口愈合不良，予相应处理后愈合良好。45例患者术后均获随访，随访时间6～26个月。随访期间2组患者均无关节活动受限、内固定松动等并发症发生。术后3个月，Tight Rope+锚钉组患肢疼痛VAS评分低于Tight Rope组，CMS评分、UCLA评分均高于Tight Rope组，差异均有统计学意义（t=2.96、14.16、18.26，P值均<0.01）。术后3个月影像学评估锁骨的垂直稳定程度，Tight Rope+锚钉组优20例、良5例，优良率为100.0％（25/25），Tight Rope组优10例、良8例、差2例，优良率为90.0％（18/20），差异无统计学意义（χ2=2.62，P=0.106）；锁骨的水平稳定程度，Tight Rope+锚钉组优20例、良5例，优良率100.0％（25/25），Tight Rope组优5例、良10例、差5例，优良率75.0％（15/20），Tight Rope+锚钉组优良率高于Tight Rope组，差异有统计学意义（χ2=7.03，P=0.008）。结论Tight Rope固定联合锚钉固定治疗重度肩锁关节脱位效果可靠，可有效减少术后的疼痛，提高锁骨的水平稳定程度和肩关节功能。

简介：ThetunnelingspectrumofanelectronandaholeinasuperlattieeofNSjunctionsiscomputedusingtheBTKapproachandthetransfermatrixmethod.Itshowssharpresonancesatsomeenergiesabovethesuperconductinggap.Thesharpertheresonanceisthemorelayersthesuperlatticehas.Wefindforthefirsttimeamechanismtobalancetheincidentandoutgoingcurrentsonthesuperlatticebyaveragingoverthephasebetweentheincidentelectronandtheincidenthole.Thismechanismismorenaturalandphysicalthanthoseinliteratures.

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简介：有有光线的波浪前面分布的旋涡的嵌套的对的一根放射状地极化的Gaussian横梁的紧张的集中性质被向量衍射理论理论上调查。在焦点的区域的光紧张能被改变旋涡的地点更加改变的结果表演在一根放射状地极化的Gaussian横梁嵌套。到在横向的方向的一个高度限制的焦点的点的从一个环形的焦点的模式的焦点的进化被观察，这被注意相应于在在输入飞机的光旋涡的地点的变化。产生的焦点的洞或点在合适的光线的阶段调整下面显著地沿着光轴导致焦点的移动，这也被观察。因此建议系统可以被使用为高、低的折射索引粒子构造悦耳的光陷井。

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简介：Ballisticthermalresistanceofgraphenenano-junctionsisinvestigatedusingnon-equilibriummoleculardynamicssimulation.Thesimulationsystemisconsistedoftwosymmetricaltrapezoidalorrectangulargraphenenanoribbons(GNRs)andaconnectingnanoscaleconstrictioninbetween.Fromthesimulatedtemperatureprofile,abigtemperaturejumpresultedfromtheconstrictionisfound,whichisproportionaltotheheatcurrentandcorrespondstoalocalballisticthermalresistance.FixingtheconstrictionwidthandthelengthofGNRs,thisballisticthermalresistanceisindependentofthewidthoftheGNRsbottomlayer,i.e.,theconvexangle.Butinterestingly,thisthermalresistancehasobvioussizeeffect.Itisinverselyproportionaltotheconstrictionwidthandwilldisappearwiththeconstrictionbeingwider.Moreover,basedonthephonondynamicstheory,atheoreticalmodeloftheballisticthermalresistanceintwo-dimensionalnano-systemsisdeveloped,whichgivesagoodexplanationonmicrocosmiclevelandagreeswellwiththesimulationresultquantitativelyandqualitatively.

简介：Itisprovedthatevery3-connectedlooplessmultigraphhasmaximumgenusatleastone-thirdofitscyclerankplusoneifitscyclerankisnotlessthanten,andifitscyclerankislessthanten,itisupper-embeddable.Thislowerboundistight.Thereareinfinitelymany3-connectedlooplessmultigraphsattainingthisbound.

简介：Thefocusingofaradiallypolarizedbeamwithoutannularapodizationoraphasefilterattheentrancepupiloftheobjectiveresultsinawidefocusandlowpurityofthelongitudinallypolarizedcomponent.However,thepresenceofaphysicalannularapodizationorphasefiltermakessomeapplicationsmoredifficultorevenimpossible.Weproposearadiallypolarizedandamplitude-modulatedannularmulti-Gaussianbeammode.Numericalsimulationshowsthatitcanbefocusedintoasharperfocalspotof0.125λ~2withoutadditionalapodizationsorfilters.Thebeamqualitydescribingthepurityoflongitudinallypolarizedcomponentisupto86%.