简介：

简介：AbstractBackground:Whether smoking is related to a decreased risk of meningioma in women is still controversial. We conducted a systematic review and meta-analysis examining the association between smoking and risk of meningiomas in women.Methods:Two authors independently performed a systematic literature review in the PubMed, Cochrane Library, and EMBASE databases. We identified case-control and cohort studies quantifying associations between smoking and risk of meningioma in women. A meta-analysis by pooling studies was performed according to the multivariate-adjusted risk estimates and 95% confidence intervals (CIs) preferentially. We further conducted additional subgroup and sensitivity analyses to explore possible explanations of the results.Results:A total of seven observational studies were included, with a total of 2132 female patients diagnosed with meningiomas. Ever smoking was associated with a significantly reduced risk of meningioma in women, with pooled odds ratio (OR) of 0.83 (95% CI 0.70-0.98). Similar findings were noted for current (OR 0.78, 95% CI 0.66-0.93) and past (OR 0.82, 95% CI 0.71-0.94) smokers. However, considering the areas, the OR of ever smoking was 0.77 (95% CI 0.68-0.87) in three American studies, but 0.99 (95% CI 0.73-1.35) in four studies conducted in other countries.Conclusions:Based on limited epidemiological evidence, a decreased risk of meningioma in women smokers was only observed in American studies rather than studies conducted in other countries.