简介：Objective:Toreviewtheliteratureonassociationsbetweencardiovasculardiseasesandtobaccouse,includingrecenttrendsinsmokingbehaviorsandclinicalapproachesforcessationofsmoking.Methods:Aliteraturereviewofrecentscientificfindingsforsmokingandcardiovasculardiseasesandrecommendationsforobtainingcessation.Results:Tobaccosmokingiscausallyrelatedtocardiovasculardisease,withnearlyahalfmilliondeathsannuallyattributedtocigarettesmokingintheUnitedStates.Thehuman,economic,medical,andindirectcostsareenormous.Secondhandsmokeasinhaledfromtheenvironmentalsoplaysanimportantroleinthegenesisofcardiovasculardiseases.Arecenttrendintheuseofe-cigarettesisnotedparticularlyamongyouth.Forchildren,preventionisthebeststrategy.Foradultsmokers,behavioraltreatments,self-helpapproaches,andpharmacologictherapiesarereadilyavailable.Clinicianscanhaveasignificantimpactonpatients’smokinghabits.Addingtoindividualstrategies,regulatorycommunityandpublichealthapproachesprovidethepotentialforeliminatingtheuseoftobacco.Conclusion:Tobaccosmokecausescardiovascularmorbidityanddeath.Clinicianscanplayaroleinpreventingsmokingandpromotingcessation.

简介：NoSmokingDaycomesonceayear.Itcallsonpeopletoquitsmoking,butthere'restillsomanysmokersintheworld.Worsestill,thenumberofsmokersisincreasingdaybyday.Asweknow,smokingisabadhabit.Smokingisharmfulnotonlytoasmokerhimselfbutalsotothepeoplearound.Itissaidthatifyousmokeonecigarette,yourlifewillbeasecondshorter.Inotherwords,smokingmeansbuyingdeathwithmoney.I'velearnedfromanewspaperthattensofthousandsofpeopleintheworlddiefr...

简介：Kidswhosmokeliketothinkthattheyareimmortal②-oratleastthatiftheystopintime,theirlungswillheal.Butareportinlastweek'sJournaloftheNationalCancerInstitutesuggestsearlysmokingmaytrigger③changesinDNA④thatputyoungsmokersathigherriskforcancereveniftheylaterquit.Researchersstudyinglungcancerpatientsroundthatthosewiththeworstgenetic⑤damagewerenotthosewhosmokedlongestbutthosewhostartedyoungest.What'smore,theearliertheystarted,themorewerethedamage.

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简介：Purpose:Theaimofthisstudywastoevaluatetheprogram"Nomoresmoking!It’stimeforphysicalactivity",withamixedmethodsdesign,inordertocollectinformationtoimprovetheprogramforfutureapplications.Methods:Fortypatientsacrossfiveanti-smokingclinicsinCentralGreececompletedtheprogram.Counselors’recordsandparticipants’questionnairesandinterviewswereusedasdatainordertoevaluatetheprograms’processandoutcome.Results:Quantitativemeasuresbeforeandaftertheprogramrevealedsignificantdifferencesonsmokingbehavior,physicalactivity(PA)behavior,self-efficacy,andsmokinghabitmeasures.QualitativedataimpliedthatthepromotionofPAasacessationaidwasperceivedaspositivebytheparticipantsandbothparticipants’andcounselors’statementswereencouragingfortheeffectivenessofPApromotionduringtheprogramasacessation-aidtechnique.Conclusion:Evaluationofthe"Nomoresmoking!It’stimeforphysicalactivity"programshowedencouragingresults.PeoplewhotrytoquitsmokingcanbecomemorephysicallyactivethroughtargetedinterventionandtheyregardPAasasignificantaidintheireffortstoquitsmoking.

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简介：AbstractBackground:Tobacco consumption is more life-threatening in people living with human immunodeficiency virus (HIV) than within the general population; therefore, people living with HIV (PLWH) should be highly motivated to take action towards quitting smoking at or after HIV diagnosis. The aim of this systematic review with meta-analysis was to investigate changes in smoking habits among PLWH over time.Main text:We considered prospective and retrospective cohort studies including PLWH aged 15 years and above, which have measured the prevalence of tobacco smoking (current, former or never) at study initiation and completion, and published between January 1, 2000 and April 15, 2018 without language or geographical restriction. We searched PubMed, EMBASE, Web of Science, Africa Journal Online, and Global Index Medicus. We used a random-effects model to pool data. Nine studies were included. The proportion of current and former smokers decreased slightly over time, around 2.5 and 3.8%, respectively. However, the proportion of never smokers decreased sharply by 22.5%, and there were 2.1 and 1.5% PLWH who shifted from never and former smoking to current smoking, respectively. On the other hand, 10.5% PLWH shifted from current to former smoking, 7.1% tried to quit tobacco consumption but failed, and 10.1% stayed in the "never smoking" category over time.Conclusions:PLWH seem not to change positively their smoking habits towards quitting tobacco consumption. There is urgent need to increase actions aimed at helping this vulnerable population to quit tobacco consumption, including individually tailored therapeutic education, psychosocial and pharmacologic supports.

简介：AbstractBackground:The preferred treatment for uncomplicated type B dissection (thoracic endovascular aortic repair [TEVAR] or medical) is still under debate. Since 2001, our center has performed TEVAR for uncomplicated type B dissection. Based on our data, 5- and 10-year survival rates among patients with uncomplicated type B dissection after TEVAR were 96.5% and 83.0%, respectively. We, therefore, believe that TEVAR is preferable for uncomplicated type B dissections. This study analyzed the impact of a pre-operative smoking history on long-term survival after TEVAR in patients with uncomplicated type B dissections.Methods:From May 2001 to December 2013, data from 751 patients with type B dissections were collected and analyzed. Patients were divided into two groups (337 smoking patients and 414 non-smoking patients). The Kaplan-Meier method and log-rank test were used to compare survival curves of the two groups. Multivariable analyses using the Cox proportional hazards model were used to estimate the effects of smoking on survival rates.Results:The 5- and 10-year survival rates of non-smokers were 97.6% (95% confidence interval [CI], 96.0%-99.2%) and 87.0% (95% CI, 81.6%-92.7%), respectively, and 94.9% (95% CI, 92.2%-97.7%) and 73.8% (95% CI, 62.3%-87.5%) for smokers, respectively (Log-rank test, P = 0.006). Multivariable analyses showed that smoking increased the risk of death during follow-up, 2.1-fold when compared to non-smokers (P = 0.039).Conclusion:A pre-operative smoking history increases long-term mortality rates after TEVAR in patients with uncomplicated type B dissections.

简介：AbstractBackground:Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events. This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target lesions.Methods:Consecutive patients with coronary heart disease who underwent two serial coronary angiographies were included. All coronary non-target lesions were recorded at first coronary angiography and analyzed using quantitative coronary angiography at both procedures. Patients were grouped into non-smokers, quitters, and smokers according to their smoking status. Clinical outcomes including rapid lesion progression, lesion re-vascularization, and myocardial infarction were recorded at second coronary angiography. Multivariable Cox regression analysis was used to investigate the association between smoking status and clinical outcomes.Results:A total of 1255 patients and 1670 lesions were included. Smokers were younger and more likely to be male compared with non-smokers. Increase in percent diameter stenosis was significantly lower (2.7 [0.6, 7.1]% vs. 3.5 [0.9, 8.9]%) and 3.4 [1.1, 7.7]%, P= 0.020) in quitters than those in smokers and non-smokers. Quitters tended to have a decreased incidence of rapid lesions progression (15.8% [76/482] vs. 21.6% [74/342] and 20.6% [89/431], P= 0.062), lesion re-vascularization (13.1% [63/482] vs. 15.5% [53/432] and 15.5% [67/431], P= 0.448), lesion-related myocardial infarction (0.8% [4/482] vs. 2.6% [9/342] and 1.4% [6/431], P= 0.110) and all-cause myocardial infarction (1.9% [9/482] vs. 4.1% [14/342] and 2.3% [10/431], P= 0.128) compared with smokers and non-smokers. In multivariable analysis, smoking status was not an independent predictor for rapid lesion progression, lesion re-vascularization, and lesion-related myocardial infarction except that a higher risk of all-cause myocardial infarction was observed in smokers than non-smokers (hazards ratio: 3.00, 95% confidence interval: 1.04-8.62, P= 0.042).Conclusion:Smoking cessation mitigates the increase in percent diameter stenosis of coronary non-target lesions, meanwhile, smokers are associated with increased risk for all-cause myocardial infarction compared with non-smokers.

简介：Objective:ToinvestigatewhethervitaminDreceptorgene(VDR)BsmI-rs1544410andFokI-rs2228570polymorphisms,smokingduration,andbodymassindex(BMI)areriskfactorsforcutaneousmelanoma,especiallymetastaticmelanoma.Methods:Westudied120cutaneousmelanomacases[68stageIandIInon-metastaticmelanoma(NMetM)patients,plus52StageIIIandIVmetastaticmelanoma(MetM)patients],and120matchinghealthycontrolsfromnortheastItaly.VDRpolymorphismsweremeasuredbyrestrictionfragmentlengthpolymorphismanalysis.AbsenceorpresenceofBsmIandFokIrestrictionsiteswasdenotedby'B'and'F'orby'b'and'f,'respectively.Results:VDR-BsmIbbgenotypewasmorefrequentamongMetM(32.7%)thanamongNMetMcases(13.2%),withoddsratio(OR)=3.18.Comparisonofallmelanomapatientsvshealthycontrolsshowedthatthefollowingbiomarkerswereatrisk:≥20yearsofsmoking(OR=2.43);≥20yearsofsmokingcombinedwithbb(OR=4.78),Bb+bb(OR=2.30),Ff(OR=3.04),andFf+ff(OR=3.08);obesity(BMI>30Conclusions:RiskfactorsforcutaneousMetMincludetwoVDRpolymorphismscombinedwithsmokingdurationandobesity.Resultssuggestgene-environmentimplicationsinmelanomasusceptibilityandseverity.Futurestudiesinlargercohortsandinsubjectswithdifferentgeneticbackgroundarewarrantedtoextendourfindings.