简介：HeparinwascovalentlyimmobilizedontopolyurethanesurfaceviaaPEGspacerbyamicrowave-assistedapproachtoimprovebloodcompatibility.Firstly,amino-terminatedpoly(ethyleneglycol)(APEG)wasrapidlygraftedontoPUsurfacewithin20minbyatwo-stepmethodinvolvingmicrowave-assistedMDI-functionalizationandsubsequentmicrowave-assistedAPEGcoupling.Then,heparinwascovalentlyimmobilizedthroughanamidelinkagebythedirectcouplingofthecarboxylicacidofheparinwiththeaminogroupofAPEGonPUsurfaceusingcarbodiimidecouplingreaction.ThesurfacestructureandpropertieswerecharacterizedbyX-rayphotoelectronspectroscopy(XPS),atomicforcemicroscopy(AFM)andwatercontactanglemeasurements.Theresultsrevealedthatheparin-immobilizedPUsurfacehadslightlyincreasedroughnessandsignificantlyimprovedhydrophilicityincomparisontotheoriginalPUsurface.Theanticoagulantactivityoffilmswasevaluatedbywholebloodclottingtime(CT)andprothrombintime(PT).Complementactivationwasassessedbydetectingcomplementfragment3aconcentrationsofserumexposedtothefilms.Theresultsrevealedthatthemicrowave-assistedheparin-immobilizedPUfilmshadexcellentantithrombogenicityandsuppressedcomplementactivation,indicatingimprovedbloodcompatibility.

简介：与优秀biomechanical相容性开发新钛合金是一个重要研究方向外科植入材料。现在的纸总结生物医学的钛合金的国际研究和开发。瞄准增加biomechanical相容性，它也介绍合金设计的探索和改进，机械处理，微观结构和阶段转变，并且以后最后为关于生物医学的钛合金的科学研究构画出方向。