简介：

简介：

简介：摘要：在《义务教育英语课程标准（2011年版）中，对小学阶段语音二级目标做了如下要求：了解简单的拼读规律；能根据拼读的规律读出简单的单词。人教版PEP小学英语教材（三年级起点）从三年级（下）到五年级（下）安排了Let’s spell板块的语音教学，但是教学内容和操练比较单薄和单调，不利于调动学生学习的积极性和学习效果，提升学生的思维品质。本文中，笔者将结合自己的教学实例，探讨如何从不同的维度入手，以多样的语音训练方式，提升学生的学习兴趣，从而深化学生们对英语语音的感知，拓宽学生的思维。

简介：摘要：“创新是一个民族的灵魂”，随着人工智能的不断发展和深化，小学信息技术课程标准中添加了程序设计模块，目标是为了让孩子理解编程的基本思想，培养学生发现问题、分析问题、解决问题和学生的创造能力。

简介：摘要：分部积分法是解决积分问题的常用方法，但u和dv选择不正确就难解出题目，所以恰当的选择u和dv是运用分部积分法解题的关键。本文将被积函数中u和dv的选择固化，解决选择的困惑。

简介：摘 要 该文主要为了介绍U型槽围护桩施工中，长螺旋钻孔灌注桩施工的机械配置，钻孔排土原理、混凝土压灌法施工，后插钢筋笼，适用范围，实际应用及持力层与电流关系等进行了叙述。

简介：摘要：自古以来，人工开凿水道一直是农业灌溉的关键环节。伴随我国农业的迅速发展，以灌溉为目的的人工渠道形式也呈现出梯形、U形等多种形式。其中，通过大量的实践活动，得出的理论基础是：U型渠道与其他渠道相比，具有耐久、方便等特点，在中小型农田灌溉中能起到比较广泛的作用。U形沟道在农业灌溉的具体应用中，需要综合考虑沟道的地形、地势、海拔、温度等因素，在荒漠、戈壁等干旱地区，实际设计沟道时，需适当改变沟道外倾角，以减少水分蒸发，提高水资源利用率，节约用水；在高纬度地区、高原地区等低温条件下，沟道内衬混凝土时，需适当增加U形沟道外倾角，增加其抗寒能力和稳定性，防止沟道在极端气候条件下遭到破坏。

简介：

简介：摘要：“国际表达、中国故事”，既是一种媒介实践与创新，也是一个关于如何实现中国故事他者表述的学术命题。本文选取B站中五个国家的知名UP主作为研究样本，通过对其创作成果的内容分析与叙事分析，探寻他者视角下国际UP主的创作特征与叙事策略，分析其意义与问题，进而为走出海外、讲好中国故事提供新的有效思路。

简介：

简介：［摘要] 语言教学需要有浸润式的“亲身感受”环境，听说课需要教师利用活动载体设计有效任务等来训练学生的听说能力。本文从观察发现制约学生听说能力因素着手，结合自身教学实践，提出听说课教学“三五”模式:“五个设定”、“五个挖掘”和“五个夯实”。

简介：

简介：【摘要】思维可视化工具以视觉表征的形式呈现思维过程和思维结果。在阅读教学中，带领学生利用思维可视化工具对文章进行可视化解读，能够锻炼学生总结提炼的能力，加强对文章内容和逻辑的深层次理解，同时增强学生学习兴趣，实现从知识灌输到能力发展的转变。

简介： 摘 要：长期演进（ Long-Term Evolution， LTE）与 WiFi是分别工作在授权频段及非授权频段的异构系统， 需解决二者的共存问题。本文基于 Q学习建立了一种共存机制，可 提高信道利用率和系统总吞吐量及传输比例 。

简介：摘 要：本文主要讲述河涌改移遇到U型槽深基坑开挖段如何同步施工，通过对设计方案的优化和调整，编制合理的施工方案，减少两个基坑的相互干扰，既保证基坑安全，又要完成节点工期。本文总结了并行基坑开挖过程中的施工控制要点，结合现场实际问题分析了并行基坑施工过程中存在的施工风险和管理措施，对后续并行基坑开挖提供了借鉴，希望对后续的类似施工有所帮助。

简介：摘要：

简介：摘要：PVC-U管材的全称为硬聚氯乙烯管材，其制造原料主要是聚氯乙烯树脂，辅助的原料还有填充剂以及稳定剂等等。将相关材料进行充分的搅拌、混合、加热，最后制作成具有一定形态的硬聚氯乙烯管材。PVC-U管材从形态上分析和结构上均有多个种类，如常见的有芯层发泡管、中空壁管、多孔管、实壁管、消音螺旋管等等。正因为PVC-U管材种类划分较多，所以在社会各方面的应用范围也比较广泛，因此，PVC-U管材的质量问题则显得非常重要。以下就是从PVC-U管材生产的工艺流程入手，进而分析PVC-U管材的成型工艺参数、PVC-U管材的工艺条件及控制措施、PVC-U管材质量问题的表现以及产生质量问题的原因分析等步骤进行阶段性的质量现状分析，从而提出提高PVC-U管材质量的措施和建议，以便为以后的工程建筑质量更添一份保证。

简介：AbstractImportance:Congenital tuberculosis (TB) is a rare, potentially fatal disease. There is currently a lack of detailed clinical information available regarding this disease.Objective:This retrospective study investigated the clinical manifestations, treatment, and long-term prognosis of congenital TB.Methods:Patients were treated in Beijing Children’s Hospital, Capital Medical University (Beijing, China) between 2009 and 2018. Their demographic data, maternal and family histories, symptoms and signs, treatment information, and follow-up data were retrospectively collected using the hospital’s electronic information system.Results:Ten infants with congenital TB were enrolled. The mean gestational age was 36.6 ± 2.2 weeks and mean birth weight was 2517 ± 487 g. All 10 patients exhibited fever, nine patients (90%) had anemia, and six patients (60%) had extrauterine growth retardation. On chest computed tomography scans, all 10 patients presented multiple pulmonary nodules and four patients (40%) had mediastinal adenopathy. Nine out of ten (90%) completed the T-spot test, and eight of them (8/9, 89%) were positive. Anti-TB treatment was initiated upon diagnostic confirmation. All patients (100%) received combined treatment with isoniazid (INH) and rifampicin (RIF). Eight of 10 patients (80%) received combined treatment with INH, RIF, and pyrazinamide. The survival rate was 100%. One patient was lost to follow-up and four patients are currently continuing treatment. Three of nine patients (33%) achieved normal developmental milestones at 6 months of age.Interpretation:Early diagnosis based on maternal history, typical imaging results, and timely treatment can improve outcomes in infants with congenital TB.

简介：AbstractBackground:Previous studies have demonstrated that various circular RNAs are involved in the malignant proliferation of cancers, such as liver cancer, lung cancer, breast cancer, and others. The potential role of circular RNAs in glioblastoma, however, is still uncertain. In this study, we aimed to study the potential role of hsa_circ _01844 in glioblastoma.Methods:Using reverse transcription-polymerase chain reaction (RT-PCR) method, hsa_circ_01844 expression was measured in five glioblastoma samples and five normal brain samples. To evaluate the potential function of hsa_circ_01844 in glioblastoma, hsa_circ_01844 was overexpressed in glioblastoma cell lines (U251 and U87 cells). Using these two cell lines, in vitro experiments including the flow cytometry assay, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay, Transwell assay, and cell apoptosis assay were performed to investigate the role of hsa_circ_01844 in glioblastoma. Student t test and one-way analysis of variance were used for statistical analysis.Results:The expression of circular RNA hsa_circ_01844 was lower in glioblastoma tissues when compared with the normal brain tissues by RT-PCR method (0.034 ± 0.036 vs. 1.630 ± 0.891, P < 0.001). Using two glioblastoma cell lines, we found that overexpression of hsa_circ_01844 in glioblastoma cells suppressed their proliferation, colony formation, migration, and increased the apoptotic rate compared with empty vector group and blank control group (all P < 0.05).Conclusion:Hsa_circ_01844 shows decreased expression in glioblastoma and its overexpression induces apoptosis and inhibits proliferation, migration, and invasion of glioblastoma cells.

简介：无