简介：Newmarkdesignspectrahavebeenimplementedinmanybuildingcodes,especiallyinbuildingcodesforcriticalstructures.PreviousstudiesshowthatNewmarkdesignspectraexhibitloweramplitudesathighfrequenciesandlargeramplitudesatlowfrequenciesincomparisonwithspectradevelopedbystatisticalmethods.Toresolvethisproblem,thisstudyconsidersthreesuitesofgroundmotionsrecordedatthreetypesofsites.Usingthesegroundmotions,influencesoftheshear-wavevelocity,earthquakemagnitudes,source-to-sitedistancesontheratiosofgroundmotionparametersarestudied,andspectrumamplificationfactorsarestatisticallycalculated.Spectralboundsforcombinationsofthreesitecategoriesandtwocasesofearthquakemagnitudesareestimated.Sitedesignspectrumcoefficientsforthethreesitecategoriesconsideringearthquakemagnitudesareestablished.TheproblemsofNewmarkdesignspectracouldberesolvedbyusingthesitedesignspectrumcoefficientstomodifythespectralvaluesofNewmarkdesignspectraintheaccelerationsensitive,velocitysensitive,anddisplacementsensitiveregions.

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简介：Themechanismofhealtheffectscausedbyorganohalogenpollutants,e.g.,toxinsfromelectronicwaste(e-waste),ispoorlyunderstood.WesupposedthatmicroRNAs(miRNAs),animportantpost-transcriptionalregulator,couldplayaroleinthisprocess.Inthisstudy,fastingperipheralbloodsampleswerecollectedfromresidentslivingatane-wastesiteinnorthernChinaandanearbyreferencepopulation.Concentrationsofe-wasterelatedorganohalogenpollutantsinplasmafromtheexposuregroupwerehigherthanthecorrespondingmeasurementinthereferencegroup.Correspondingly,sixtymiRNAsinplasmashowed>2-foldchangebetweenthetwogroupsinmicroarrayanalysis.Amongthem,miR-125a-5pwasconfirmedtobeupregulatedbyqRT-PCRanditsvalidatedtargetswereenrichedinresponsestoxenobioticsandcancerrelatedpathways.Furthermore,significantpositivecorrelationswerefoundbetweenlevelsofmiR-125a-5pinplasmaandreactiveoxygenspecies(ROS)inpolymorphonuclearneutrophilleukocytes(P<0.05).Theseevidencessuggestedoxidativestressmightbeanintermediatebetweene-wasterelatedPOPsexposureandalterationofplasmamiRNA.