简介：自然数集按（mod6）排列后，将自然数符号螺旋对称分布的规律与自然律有机关联起来研究，从中发现数集中部分合数M中所包含相同素因子P，q周期分布与等距传递的规律，即双重素数P,q实项、虚项原构、同构同因子对应组螺旋对称分布结构的形式与规律，可模拟宇宙万物的时空螺旋运动状态，模拟DNA双螺旋结构碱基（A、T、G、C）序列遗传密码结构与形式。亦可作为一种创新方法开发应用研究，为研究DNA序列结构的数学编码，研究宏观宇宙、中观生物、微观质量的对应螺旋运动状态，预测宇宙万物相互关联相互作用的变化规律与趋势，构建基于宇宙中空时序的自然数双重素数因子对应组（多组）螺旋延伸的数码模型，高度抽象探讨与理解宇宙万物运动变化的原本规律，为相关问题的表述与解决提供数码螺旋的解决方案。

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简介：DNAcondensationisanimportantprocessinmanyfieldsincludinglifesciences,polymerphysics,andappliedtechnology.Inthenucleus,DNAiscondensedintochromosomes.Inpolymerphysics,DNAistreatedasasemi-flexiblemoleculeandapolyelectrolyte.Manyagents,includingmulti-valentcations,surfactants,andneutralpoorsolvents,cancauseDNAcondensation,alsoreferredtoascoil–globuletransition.Moreover,DNAcondensationhasbeenusedforextractionandgenedeliveryinappliedtechnology.ManyphysicaltheorieshavebeenpresentedtoelucidatethemechanismunderlyingDNAcondensation,includingthecounterioncorrelationtheory,theelectrostaticzippertheory,andthehydrationforcetheory.Recentlyseveralsingle-moleculestudieshavefocusedonDNAcondensation,sheddingnewlightonoldconcepts.Inthisdocument,themulti-fieldconceptsandtheoriesrelatedtoDNAcondensationareintroducedandclarifiedaswellastheadvancesandconsiderationsofsingle-moleculeDNAcondensationexperimentsareintroduced.

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简介：AdoublehelixmodelofchargetransportinDNAmoleculeisgivenandthetransmissionspectraoffourDNAsequencesareobtained.ThecalculatedresultsshowthatthetransmissioncharacteristicsofDNAarenotonlyrelatedtothelongitudinaltransportbutalsotothetransversetransportofmolecule.Theperiodicsequencewiththesamecompositionhasstrongerconductionability.Withtheincreasingofbasescomposition,theconductiveabilityreduces,buttheweightofθdirectionrisesinchargetransfer.

简介：由直接diagonalizing脱氧核糖核酸酸(DNA)的梯子模型的Hamiltonian分子，状态的密度被获得。DNA作为一个售票员表现，这被发现什么时候内部链跳跃比小两次intrachain不那样，DNA作为一个半导体表现。

简介：Chaosgamerepresentation(CGR)isaniterativemappingtechniquethatprocessessequencesofunits,suchasnucleotidesinaDNAsequenceoraminoacidsinaprotein,inordertodeterminethecoordinatesoftheirpositionsinacontinuousspace.Thisdistributionofpositionshastwofeatures:oneisunique,andtheotherissourcesequencethatcanberecoveredfromthecoordinatessothatthedistancebetweenpositionsmayserveasameasureofsimilaritybetweenthecorrespondingsequences.ACGR-walkmodelisproposedbasedonCGRcoordinatesfortheDNAsequences.TheCGRcoordinatesareconvertedintoatimeseries,andalong-memoryARFIMA(p,d,q)model,whereARFIMAstandsforautoregressivefractionallyintegratedmovingaverage,isintroducedintotheDNAsequenceanalysis.ThismodelisappliedtosimulatingrealCGR-walksequencedataoftengenomicsequences.Remarkablylong-rangecorrelationsareuncoveredinthedata,andtheresultsfromthesemodelsarereasonablyfittedwiththosefromtheARFIMA(p,d,q)model.

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简介：采用Br模型研究了控制螺旋波破碎问题。考虑到螺旋波破碎是由于多普勒不稳定产生的,我们提出在均匀介质中引入不可激发介质缺陷和可变性介质缺陷,通过让螺旋波波头绕缺陷运动来稳定螺旋波。研究结果表明,不同的介质缺陷稳定螺旋波的能力有所不同,可变性介质缺陷防止螺旋波破碎的能力更强。这些研究结果能够为心脏学家防止心颤致死提供有用的信息。

简介：TheDNA-dependentproteinkinasecatalyticsubunit(DNA-PKcs)playsamajorroleinDNAdamagesignalingandrepair,andisalsofrequentlyover-expressedintumormetastasis.WeusedisogeniccelllinesexpressingdifferentlevelsofDNA-PKcstoinvestigatetheroleofDNA-PKcsinmetastaticdevelopment.Interestingly,ourresultsshowedthatX-rayirradiationinducedthemetastasisofDNA-PKcspositive(M059K)butnotnegative(M059J)cells;however,genisteincouldsuppresstheradiation-inducedmetastaticpotentialofM059Kcells(Fig.1).Theconcretemechanismsunderlyingthisphenomenonwillbeinvestigatednextyear.

简介：Heavyionirradiationattractalargeinterestfortwoapplications:radiotherapyandspaceradiationprotectioninmannedspacemissions.ExposuretoheavyionsradiationresultsinmultipleeffectsthroughDNAdamageinduction.Single-cellgelelectrophoresisorcometassayisknownforitsabilitytodetectDNAdamageatthesinglecelllevelandhasbeenusedforyearstoassessDNAdamage.ItcandetectlowlevelsofDNAstrandbreaksinashorttime,justusingafewsamplecells.DNAdoublestrandbreaks(DSBs)aremeasuredattheneutralcometassaycondition;underthealkalinecometassayconditionbothDNAsinglestrandbreaks(SSBs)andpartDSBsaredetected.Thetwodimensionalcometassayisamodificationofthetwooriginalcometassay,cansimultaneouslydetectDNASSBsandDSBsinthesamehumanspermatozoa.

简介：AlterationsinDNArepair,cellcycle,andapoptoticpathwaysareoftenassociatedwithcancerriskandradiationsensitivity.IndividualswithreducedDNAdamageresponsefaceagreatersensitivitytomutagenchallenge.Interindividualvariabilityinmutagenorradiationsensitivityandincancersusceptibilitymayalsobetracedbacktopolymorphismsofgenesaffectinge.g.DNArepaircapacity[1].

简介：Amongthemanyspecialfactorsinthespaceenvironment,spaceradiationespeciallyhighenergyheavyionradiationiswidelyregardedasoneofthecrucialfactorsthathazardthehealthandsafetyofastronaut.Itiswellknownthatbiologicaleffectsofradiationaredependentonthelinear-energy-transfer(LET)oftheemergentbeam.HeavyionshavehighLETandcouldinducecomplexandclusteredDNAdamage,whichismoredifficulttoberepairedthanindividuallesionsandisevenirreparable.

简介：数值模拟研究了钾离子电流对心脏系统中的螺旋波的影响,通过适当减小GK1可以有效抑制心脏中的螺旋波。抑制的物理机制为适当减小GK1可以抑制各种离子电流的激发,导致螺旋波无法自我维持。

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简介：在流体力学数值模拟中，最基本的有Lagrange方法和Euler方法。Lagrange方法可用来计算多介质系统，能够刻划多介质界面，但网格的扭曲，翻转，长宽比失调等网格大变形是一个突出问题。在Euler方法中，计算网格是固定的，但是，当系统中包含多种介质时，一定会出现在一个Euler网格中包含多种介质的情形，网格中的物理量的处理比较困难。为提高精度．一般将Lagrange方法和Euler方法结合。这时网格最优问题是一个重要的内容。

简介：微细结构在工程中的应用逐渐增多，常规的切削加工方法及手段无法直接实现微细结构的加工。针对一种特定微细结构，研究了其车削加工工艺技术。