简介：Athree-dimensionalmodelofGaAs/A1GaAsquantumdoubleringsinthelateralstaticelectricfieldisinvestigatedtheoretically.Theeigenvalueproblemwiththeeffective-massapproximationissolvedbymeansofthefinite-elementmethod.Theenergylevelsandwavefunctionsofquantum-confinedelectronsandheavyholesareobtainedandshowanagreementwithourprevioustheoreticalandexperimentalstudies.ItisshownintheapproximationofneglectingtheCoulombattractionbetweentheelectronandheavyholethatarelativelylargeStarkshiftofexcitonemissionof4meVisattainablewithanappliedelectricfieldof0.7kV/cm.

简介：WecreateaGaNphotocathodebasedongradedAlxGa1-xNbufferlayerstoovercometheinfluenceofbuffer-emissionlayerinterfaceonthephotoemissionoftransmission-modeGaNphotocathodes.Agateshapedspectralresponsewitha260-nmstartingwavelengthanda375-nmcut-offwavelengthisobtained.Averagequantumefficiencyis15%andshortwavelengthresponsesarealmostequivalenttolongwavelengthones.Thefittedinterfacerecombinationvelocityis5×104cm/s,withnegligiblemagnitude,provingthatthedesignofthegradedbufferlayersisefficientinobtaininggoodinterfacequalitybetweenthebufferandtheemissionlayer.

简介：Mitoxantrone,aclinicallyusefulantitumourantibioticforleukaemiaandbreastcancer,hasreceivedmoreattentions.Inthispaper,theinteractionbetweenmitoxantroneandcalfthymusDNAisinvestigatedbyRamanandfluorescencespectroscopies,andthebindingsiteofmitoxantronetocalfthymusDNAisexplored.TheresultsshowedthatmitoxantroneinteractswithcalfthymusDNAbasesbytheintercalationofanthracyclineintothebasepairplaneofadenine(A)andthymine(T),anditresultsinthedisruptionofthehydrogenbondsbetweencalfthymusDNAbases,andthusthecalfthymusDNAdouble-strandcanbedisruptedintotheB-formDNAdouble-strandsegments.

简介：Asecondgenerationsolaradaptiveoptics(AO)systemisbuiltandinstalledatthe1-mNewVacuumSolarTelescope(NVST)oftheFuxianSolarObservatory(FSO)in2015.TheAOhigh-ordercorrectionsystemconsistsofa151-elementdeformablemirror(DM),acorrelatingShack–Hartmann(SH)wavefrontsensor(WFS)witha3500Hzframerate,andareal-timecontroller.ThesystemsawfirstlightonMar.16,2015.Thesimultaneoushigh-resolutionphotosphereandchromosphereimageswithAOareobtained.Theon-skyobservationalresultsshowthatthecontrastandresolutionoftheimagesareapparentlyimprovedafterthewavefrontcorrectionbyAO.

简介：银纳米团簇因其独特的与尺寸相关的光、电、磁和催化性能,引起了相关研究人员的高度关注,我们团队一直专注于研究用基于DNA保护的银纳米团簇监测DNA、Hg2＋和巯基化合物。发现发生在DNA/银纳米复合物与G-四链体/血红素之间光诱导电子转移（PET）,伴随着DNA/银纳米荧光减弱。这一新的PET系统使目标生物分子,如DNA和敏感性高的ATP获得特异性和多样性的检测。首次提出一种以DNA单体作为支架的高产率银纳米簇的合成方法。在这项研究中,采用密度泛函计算理论解释了DNA保护的银纳米团簇的形成机理以及为什么富胞嘧啶DNA是荧光银纳米簇的良好支架。研究结果对DNA保护荧光银纳米簇进一步实验和理论研究提供了基本指导思想,最终可能有助于程序化合成具有光致发光性能的DNA稳定银纳米团簇。

简介：DNAtetrahedralnanostructuresareconsideredtobenewnanocarriersbecausetheycanbepreciselycontrolledandholdexcellentpenetrationabilitytothecellularmembrane.AlthoughtheDNAtetrahedralnanostructureisextensivelystudiedinbiologyandmedicine,itsbehaviorinthecellswithnanoscaleresolutionisnotunderstoodclearly.Inthisletter,wedemonstratesuperresolutionfluorescenceimagingofthedistributionofDNAtetrahedralnanostructuresinthecellwithasimulatedemissiondepletion(STED)microscope,whichisbuiltbasedonaconventionalconfocalmicroscopeandcanprovidearesolutionof70nm.

简介：近年来,石墨烯（GN）由于具有非凡的物理和化学性质而受到广泛关注,这为分析化学的发展带来了新的活力。电化学器件与GN的耦合提供了一个很好的平台,来实现对许多生物材料的诊断和检测。我们小组首次报道,利用石墨烯电极电化学自发检测存在于ssDNA和dsDNA的所有4个DNA碱基,该检测是在生理pH条件下,并且不需要预水解步骤。我们研究证明了利用独特的GO/适配体相互作用和特异性核酸适体目标识别,GO/适配子系统可以程序化地完成较复杂的ORandINHIBIT逻辑门。在不同输入相同波长的不同荧光强度下,进行多靶点调节荧光强度和ORandINHIBIT逻辑门,从而组合成组合逻辑门。组合逻辑门可利用荧光成像进行高通量诊断。在组合逻辑门的输出的基础上,我们可以找出ATP和凝血酶是否存在。这个概念的证明可以为多重分析和纳米生物医学器件对多个输入的化学物质响应提供一种新方法。

简介：肿瘤是严重威胁人类健康和生命的第二大疾病,尽管已发展多种治疗方法,目前仍然是医学界所面临的挑战之一。针对癌症发生的根源,我们发展了新型激光免疫疗法。激光免疫疗法有效结合光热靶向治疗和免疫治疗,通过局部肿瘤损伤,激发宿主免疫防御系统,诱导宿主产生特异性抗肿瘤免疫反应。临床前和初步临床研究表明,激光免疫疗法能够有效地治疗转移肿瘤,并在对晚期恶性黑色素瘤患者及乳腺癌患者治疗中取得令人满意的疗效。基于原位自体全细胞抗肿瘤疫苗的原理,激光免疫疗法能够局部产生全细胞疫苗,诱发机体系统、长期的抗肿瘤免疫反应。本文将介绍激光免疫疗法的发展及临床应用。

简介：Anall-fiberopticallaserpulsemulti-passstretcherusingachirpedfiberBragggrating(CFBG)isdemonstrated.Pulsesfroma1053-nmmode-lockedfiberseedoscillatorarestretchedbymultiplepassingthroughachirpedfibergratingsetinafiberregenerativeamplifierstructure.Westretchthepulsefrom16psto1.855nsafterittransmitssevenloopsinthestretcher.Themainfactorsthataffectthestretchingresultsarediscussed.

简介：SiO_2thinfilmscontainingSi_(1-x)Ge_xquantumdots(QDs)arepreparedbyionimplantationandannealingtreatment.Thephotoluminescence(PL)andmicrostructuralpropertiesofthinfilmsareinvestigated.ThesamplesexhibitstrongPLinthewavelengthrangeof400—470nmandrelativelyweakPLpeaksat730and780nmatroomtemperature.Blueshiftisfoundforthe400-nmPLpeak,andtheintensityincreasesinitiallyandthendecreaseswiththeincreaseofGe-dopingdose.Weproposethatthe400—470nmPLbandoriginatesfrommultipleluminescencecenters,andthe730-and780-nmPLpeaksareascribedtotheSi=OandGeOluminescencecenters.

简介：荧光共振能量转移（FRET）技术作为一种能在生物活体和体外检测纳米级距离变化的工具，为研究生物大分子内部结构、性质、反应机理及其动态监测，乃至定量分析等提供了一条快速简便的途径。由于量子点（QDs）具有独特的光学性质（宽吸收、窄发射、抗光漂白及荧光可调），近年来基于QDs的FRET体系已在生物医学传感、免疫及活细胞内生物大分子的相互作用方面得到了广泛应用。