简介：AIM:ToexaminetheprotectiveeffectsofGinkgobilobaextract(GbE)onthelearningandmemoryintheAlzheimerdisease(AD)modelinducedbyaluminumsaltinrats,andtoexaminethepotentialmechanisms.METHODS.TheADmodelofratswasinducedbyadministrationanddrinkingofaluminumchloridesolution.Theabilitiesofspatialleafingand

简介：Thepresentresearcheffortwasaimedtodevelopcolontargeteddrugdeliverysystem(CTDDS)ofrhubarb,herbaldrugusingamixedfilmofpectinandethylcellulose(EC).Pectinandethylcelluloseweremixedinvariousproportionstocoatthecoretablettotargetcolon.Themethanolicextractofrhubarbwasusedandthedoseoftheextractineachformulationwasfinalizedbyestimatingtheemodincontentinitbyhighperformacethinlayerchromatography(HPTLC).Invitrodrugrelease,erosionstudyinpresenceandabsenceofpectinaseenzymeandreleaseconstant(K)ofzeroorderwasmeasuredforeachformulation.Theformulationwasoptimizedbyusing32fullfactorialdesign.Formulationhaving50%pectinasacoatingpolymerwith12%coatweightwasselectedasanoptimizedformulation(OF)onthebasisof%similaritywithmaximumdesirabilitybutthisformulationwasnotabletoretardthereleaseofdruginstomachandupperintestinefully.SoitwasfurthercoatedwithEudragitS100(ES)(3%coatweight).Theoptimizedformulation,coatedwithESindicatedsignificantlaxativeactivityonloperamideinducedconstipationinrats.TheresultsrevealedthatCTDDSofrhubarbusingtwocombinedapproachesofbiodegrablemicroflora-activatedsystemandpH-sensitivesystemexhibitedapromisingcolontargetingperformance.

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