简介:AIM:Toevaluatethelong-termresultsandcomplicationsofahmedglaucomavalve(AGV)implantationinrefractoryglaucoma.·METHODS:Aretrospectivereviewof13patients(13eyes)withrefractoryglaucomawhounderwentAGVimplantationandhadaminimumfollow-upof18monthswasperformed.Allpatientsunderwentacompleteophthalmologicexaminationandintraocularpressure(IOP)measurementbeforesurgeryandat1month,3months,6months,1yearaftersurgeryandyearlyafterwards.Complicationsandthenumberofantiglaucomamedicationsneededwererecorded.·RESULTS:Meanagewas27.3±16.0years.Alleyes(100%)hadatleastonepriorincisionalsurgery.Meanfollow-upwas61.3±30.8months.IOPwasreducedfromameanof35.0±7.0mmHgto18.2±7.9mmHgat12monthsandto17.0±4.1mmHgat96months(P<0.05)withalowernumberofmedicationsfrombaseline,76.9%patientsrequiredadditionalprocedurestoachievethesuccesscriteriasetbypreviouslypublishedseries.Themostcommoncomplicationswereencapculatedcystformationineighteyes(61.5%)andtubeexposureinfoureyes(30.8%).·CONCLUSION:EncapsulatedcystformationwasthemostcommoncomplicationwhichhinderedsuccesfulIOPcontrolafterAGVimplantinsertionforrefractoryglaucoma.Despitecystexcisionwithanti-fibroticagents,successfulIOPreductionwasnotachievedin76.9%ofthepatientswithoutantiglaucomamedication.
简介:·Glaucomaisoneoftheleadingcausesofvisualimpairmentandblindnessworldwide.Ofknownriskfactorsforglaucoma,anincreasedinintraocularpressureismosthighlycorrelatedwithglaucomatousdamage.Irrespectiveofthecause,apoptosisoftheretinalganglioncellsistheeventualoutcome.Itiswidelyacceptedthatglaucomaisaneurodegenerativediseasethatisstronglycorrelatedwithcentralnervoussystemdisorders,suchasAlzheimer’sdisease.Thesetwodisordersalsosharesomesimilaritiesinpathogenicmechanisms.Recentstudiessuggestthatthetransientreceptorpotentialcanonical6channelcouldworktogetherwithbrain-derivedneurotrophicfactortopromoteneuronsurvivalinbrainandretina.Inthisstudy,weproposethattransientreceptorpotentialcanonical6maycontributetothepathogenesisofhumanglaucomaandbecomeapotentialtherapeutictarget.
简介:目的:观察MoriaM2型90与110μm角膜刀制作角膜瓣在准分子激光角膜原位磨镶术(laserinsitukeratomileusis,LASIK)的疗效和并发症,探讨MoriaM2型90刀头在LASIK中应用的有效性、安全性和优点。方法:选取通过术前检查并自愿行LASIK手术的患者105例202眼,按随机数字表分成两组,使用MoriaM2型90刀头LASIK患者51例98眼,110刀头LASIK患者54例104眼做对照,术后即使用光学相干断层扫描仪(OCT)检测两组角膜瓣厚度,观察两组术后1d;1wk;1,3mo裸眼视力、矫正视力和角膜瓣形态、对合情况、并发症。结果:90刀头组术后角膜瓣厚度为118.3±15.2μm,110刀头组术后角膜瓣厚度为130.5±17.1μm,有显著性差异。90刀头组均未发现层间点状金属碎屑,110刀头组有层间点状金属碎屑个例(12例),有显著性差异。两组角膜瓣形态、对合情况、术后反应、术后裸眼视力相当。结论:应用90刀头LASIK的疗效及并发症和110刀头LASIK相当,但90刀头保留角膜基质床相对较厚,可矫治的屈光度更大,术后层间点状金属碎屑并发症更少,具有更好的安全性和更宽的适应范围。