简介：Accumulatingevidencefromepidemiologicalandexperimentalstudiesindicatethatobesity,anditsrelatedmetabolicconsequencesofinsulinresistanceandtype2diabetes,areassociatedwithacceleratedcognitivedecline(Yatesetal.,2012).Theetiologyofneurodegenerationinobesityisundoubtedlycomplex,withvascular,metabolic,inflammatory,andstructuralchangesalllikelytoplayarole(Yatesetal.,

简介：TheRho/Rho-associatedcoiled-coilcontainingproteinkinase(Rho/ROCK)pathwayisamajorsignalingpathwayinthecentralnervoussystem,transducinginhibitorysignalstoblockregeneration.Aftercentralnervoussystemdamage,themaincauseofimpairedregenerationisthepresenceoffactorsthatstronglyinhibitregenerationinthesurroundingmicroenvironment.ThesefactorssignalthroughtheRho/ROCKsignalingpathwaytoinhibitregeneration.Therefore,athoroughunderstandingoftheRho/ROCKsignalingpathwayiscrucialforadvancingstudiesonregenerationandrepairoftheinjuredcentralnervoussystem.