简介:Regenerationinthecentralnervoussystem(CNS)islimited,andCNSdamageoftenleadstocognitiveimpairmentorpermanentfunctionalmotorandsensoryloss.Impairedregenerativecapacityismultifactorialandincludesinflammation,lossofthebloodbrainbarrier,andalterationintheextracellularmatrix(ECM).OneofthemainproblemsistheformationofaglialscarandtheproductionofinhibitoryECM,suchasproteoglycans,that