简介：Ourpreviousstudieshavehistomorphologicallyconfirmedthatnanofibrouspoly(3-hydroxybutyrateco-3-hydroxyvalerate)conduitcanbeusedtorepair30-mm-longsciaticnervedefects.However,therepaireffectsonratbehaviorsremainpoorlyunderstood.Inthisstudy,weusednanofibrouspoly(3-hydroxybutyrate-co-3-hydroxyvalerate)conduitandautologoussciaticnervetobridge30-mm-longratsciaticnervegaps.Within4monthsaftersurgery,ratsciaticnervefunctionalrecoverywasevaluatedpermonthbybehavioralanalyses,includingtoeoutangle,toespreadanalysis,walkingtrackanalysis,extensorposturalthrust,swimmingtest,open-fieldanalysisandnociceptivefunction.Resultsshowedthatratsciaticnervefunctionalrecoverywassimilarafternanofibrouspoly(3-hydroxybutyrate-co-3-hydroxyvalerate)conduitandautologousnervegrafting.Thesefindingssuggestthatnanofibrouspoly(3-hydroxybutyrate-co-3-hydroxyvalerate)conduitissuitableinuseforrepairoflong-segmentsciaticnervedefects.