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简介：Inrecentyears,Percutaneouscoronaryintervention(PCI)asaneffectivetreatmentforcoronaryheartdiseasehasbeenwidelycarriedoutinChina.However,peopleisstillconfrontedwiththeproblemthattheincidenceofin-stentrestenosis(ISR)afterPCI.Someriskfactorsofcoronaryheartdiseasehavebeenobviouslyknown,butthein-dependentpredictorfactorsfortheISRhasnotbeenclear.ClarifyingriskfactorsforISRtoestablishinterferingmeas-uresmaybeanewdirectionforPCItreatmentinthefuture.Atpresent,ithasbeenreportedthataldosterone(ALD)maybeinvolvedinISR.InordertofurtherinvestigatetherelationshipbetweentheserumALDlevelsandISR,ourre-searchwastodeterminetheALDandotherserummarkerstoexploretheimpactfactorsofISR.MethodsWemeas-uredserumALD,highsensitivityC-reactiveprotein(hs-CRP),adiponectin(ADP)andotherindicatorsin258pa-tientswithcoronarystenting,andmaderoutinefollow-upfor6-9monthstoperformcoronaryangiography.Accordingtotheresultsofcoronaryangiography,allpatientsweredividedintorestenosisgroupandnon-restenosisgroup.Wean-alyzedtherelationshipbetweenALD,otherindicatorsandISRtoexplorewhetherserumALDwasanindependentriskfactorISR.ResultsSerumALDlevelsweresignificantlyhigherinrestenosisgroupthannon-restenosisgroup.Logis-ticregressionanalysisshowedthatdiabetes,ALD,hs-CRPandcomplexlesionswerealsoindependentriskfactorsforISR(P<0.05),whiletheADPwasasaprotectivefactorforISR(P<0.05).ConclusionsALDisoneofinde-pendentriskfactorsforISRafterundergoingcoronarystentimplantationinpatients.Ithasthepossibilityofbecomingonenewmethodinthismedicalfield.

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