简介:Thesimulationofthisprocessandtheeffectsofprotectionirojectslaysthefoundationofitseffectivecontrolanddefence.Themathematicalmodeloftheproblemandupwindsplittingalternatingdirectionmethodwerepresented.Usingthismethod,thenumericalsimulationofseawaterintrusioninLaizhouBayAreaofShandongProvivcewasfinished.Thenumericalresultsturnedouttobeidenticalwiththerealmeasurements,sothepredictionoftheconsequencesofprotectionprojectectsisreasonable.
简介:无
简介:一个适应neuro模糊的推理系统(ANFIS)被介绍预言横梁的动态行为。轴的力量和大排水量的效果在分析被考虑。为横梁的动态特征的测试的一个数据库从试验性的测试被开发。为单个、多重步的横梁的非线性的颤动力量的回答从有限元素方法被计算(女性),为比较的试验性的测试和neuro模糊的模型。neuro模糊的模型为神经网络和模糊逻辑的联合提供一个一般框架。它与合并真实世界的系统的模糊性质的更多的选择是更灵活的并且是为横梁的动态特征的一个有用评价工具。因此,ANFIS能是为受到轴的负担和大排水量的多重步的横梁的动态行为分析的一个有用工具。
简介:Accuratepredictionofunsteadyseparatedturbulentflowsremainsoneofthetoughesttasksandapracticalchallengeforturbulencemodeling.Inthispaper,a2DflowpastacircularcylinderatReynoldsnumber3,900isnumericallyinvestigatedbyusingthetechniqueofunsteadyRANS(URANS).Sometypicallinearandnonlineareddyviscosityturbulencemodels(LEVMandNLEVM)andaquadraticexplicitalgebraicstressmodel(EASM)areevaluated.Numericalresultshaveshownthatahigh-performancecubicNLEVM,suchasCLS,aresuperiortotheothersinsimulatingturbulentseparatedflowswithunsteadyvortexshedding.
简介:Functionalcharacterizationofeverysingleproteinisamajorchallengeofthepostgenomicera.Thelarge-scaleanalysisofacell'sproteins,proteomics,seekstoprovidetheseproteinswithreliableannotationsregardingtheirinteractionpartnersandfunctionsinthecellularmachinery.Animportantsteponthiswayistodeterminethesubcellularlocalizationofeachprotein.Eukaryoticcellsaredividedintosubcellularcompartments,ororganelles.Transportacrossthemembraneintotheorganellesisahighlyregulatedandcomplexcellularprocess.Predictingthesubcellularlocalizationbycomputationalmeanshasbeenanareaofvividactivityduringrecentyears.Thepubliclyavailablepredictionmethodsdiffermainlyinfouraspects:theunderlyingbiologicalmotivation,thecomputationalmethodused,localizationcoverage,andreliability,whichareofimportancetotheuser.Thisreviewprovidesashortdescriptionofthemaineventsintheproteinsortingprocessandanoverviewofthemostcommonlyusedmethodsinthisfield.
简介:Antheoreticalinvestigationwasconductedtodetectthegas-solidinterfaceeffectonlaminarflowcharacteristicsforgasflowingthroughmicropassages.Inthewall-adjacentregion,thechangeinviscosityoffluidvsthedistancefromthewallsurface,asderivedfromthedkinetictheoryofgasesresultinsignificantinfluenceontheflowcharacteristicsinmicropassages.Amodelwasproposedtoaccountforthewalleffect.Analyticalexpressionsforvelocityprofilesandpressuredropwerederived,respectively,forlaminarflowofgasesinmicrotubesandinextremelynarrowparallelplaes.TheKnudsennumber,Kn,asacriterion,thattheflowcanbetreatedreasonablyasflowinmacrochannels,isdiscussed.
简介:Immunotherapyhasbecomeakeystrategyforcancertreatment,andtwoimmunecheckpoints,namely,programmedcelldeath1(PD-1)anditsligand(PD-L1),haverecentlyemergedasimportanttargets.TheinteractionblockadeofPD-1andPD-L1demonstratedpromisingactivityandantitumorefficacyinearlyphaseclinicaltrialsforadvancedsolidtumorssuchasnon-smallcelllungcancer(NSCLC).ManycelltypesinmultipletissuesexpressPD-L1aswellasseveraltumortypes,therebysuggestingthattheligandmayplayimportantrolesininhibitingimmuneresponsesthroughoutthebody.Therefore,PD-L1isacriticalimmunomodulatingcomponentwithinthelungmicroenvironment,butthecorrelationbetweenPD-L1expressionandprognosisiscontroversial.MoreevidenceisrequiredtosupporttheuseofPD-L1asapotentialpredictivebiomarker.ClinicaltrialshavemeasuredPD-L1intumortissuesbyimmunohistochemistry(IHC)withdifferentantibodies,buttheassessmentofPD-L1isnotyetstandardized.Somecommercialantibodieslackspecificityandtheirreproducibilityhasnotbeenfullyevaluated.FurtherstudiesarerequiredtoclarifytheoptimalIHCassayaswellastopredictandmonitortheimmuneresponsesofthePD-1/PD-L1pathway.
简介:Inthispaperourstudiesaboutthesequentialtestingprogramforpredictingandidentificatingcarcinogens,sequentialdiscriminantmethodandcost-effectivenessanalysisaresummarized.Theanalysisofourdatabaseofcarcinogenicltyandgenotoxicityofchemicalsdemonstratestheuncertainty.ofshort-termtests(STTs)topredictcarcinogensandtheresultsofmostroutineSTTsarestatisticallydependent.WerecommendthesequentialtestingprogramcombiningSTTsandcarclnogenicityassay,theoptimalSTTbatteries,therulesofthesequentialdiscriminationandthepreferalchoicesofSTTstorspecificchemicalclass.Forillustrativepmposesthecarclnogenicitypredictionofseveralsamplechamicalsispresented.Theresultsofcost-effectivenessanalysissuggestthatthisprogramhasvastsocial-economiceffectiveness.
简介:Inordertoconstructobjectiverelativelymappingrelationshipmodelbetweencustomerrequirementsandproducttechnicalcharacteristics,anovelapproachbasedoncustomersatisfactionsinformationdiggingfromcaseproductsandsatisfactioninformationofexperttechnicalcharacteristicswasputforwardinthispaper.Technicalcharacteristicsevaluationvalueswereexpressedbyroughnumber,andtechnicalcharacteristicstargetsequencewasdeterminedonthebasisofefficiency,costtypeandmiddletypeinthismethod.UseeachcalculatedsatisfactionsofcustomersandtechnicalcharacteristicsasinputandoutputelementstoconstructBPnetworkmodel.AndweuseMATLABsoftwaretosimulatethisBPnetworkmodelbasedonthecaseofelectricbicycles.
简介:Soilswerecollectedfrom2-year(2-y)and3-year(3-y)oldred-pineseedlingplotsintwotreenurseries,HaywardinthenorthandWilsoninthesouthwesternpartofWisconsinStaterespectively,andequilibratedwith0.01MCa(NO3)2)forsoilsolutionZnandMn(solu-ZnandMn),andwith0.01MCa(NO3)2+0.005MEDTAforsoilabsorbedZnandMn(ad-ZnandMn).BufferingcapacityofsoilZnandMn(b-ZnandMn)wasobtainedfromtheratioofad-ZnandMntothesolu-ZnandMn.Theconcernedtracesinpineseedlingneedles(ndls),stems(sts)androots(rts)weresimultaneouslymeasured.Theresultsobtainedshowthat:About60%ofsolu-andad-Znrangedfrom0.2to0.4andfrom1to2μg/gsoilrespectively.About70%ofb-Znwaswithin3-10.Thehighestcontentofsolu-Zncomparedwiththelowestshowedadiscrepanceofmorethan10-fold.ThetwoformsofsoilZnwerecommonlyhigherinWilsonthaninHaywarkNursery.About80%ofsolu-,ad-andb-Mnwerewithin3-10,5-5.8μg/gsoiland1-2respectively.Influenceoflowbufferingcapacityonsolu-ZnandMnwasabout20timesstrongerthanthatofthehigh.TheE-value,aratioofaccumulatedZnandMninneedlestothoseinthesoilsolution,isprovedtobe:E-Zn>E-Mn;E-sts>E-ndlsorE-rts;andE-2y>E-3y.Curvilinearand/orlinearcorrelationsbetweensoilsolu-,ad-andb-ZnandMnandndls-,sts-,rts-ZnandMnwereatverysignificantorsignificantlevels.Forpredictingndls-ZnandMn,tworealizableandsimplemodelsfromtworegressionequationswereestablishedthroughtheselectionofrelatedparametersanddependentvariables.BinaryregressionanalysisbasicallyeliminatedtheinfluenceofsoilpHonthepredictionofZnandMninneedles.SoilpHwasthusthoughttobeexcludedfromthemodel.