简介:Interleukin-18(IL-18)wasdiscoveredasaninterferon-γ-inducingfactorandhadacriticalroleininflammatoryandimmuneresponse.Itstimulatesnaturalkiller(NK)andTcellsandenhancesTh1immuneresponse.Theseactivatedimmunecellseliminatecancercellsandvirus-infectedcellseffectively.However,IL-18hasalsobeenfoundtopromotetumorprogression.HigherexpressionorsecretionlevelofIL-18isdetectedinvariouscancercellsincomparisonwithnormalcontrol,andIL-18isabletoinduceangiogenesis,migration/metastasis,proliferationandimmuneescape.ThesedualeffectsandthemechanismofIL-18needtobeinvestigatedfurtherasitrelatestocancer.
简介:摘要目的探讨HIV阳性合并泌尿系肿瘤患者的手术处理特点及经尿道等离子膀胱肿瘸电切术治疗膀胱癌的疗效和安全性。方法回顾性分析我院2009年—2013年经尿道膀胱肿瘤电切术治疗HIV感染合并膀胱癌18例的临床资料。结果本组18例患者膀胱肿瘤均一次性切除,无严重并发症。术后随访1—3年,肿瘤复发6例,复发率为33.3%。结论经尿道膀胱肿瘤电切术具有手术操作安全、创伤小、手术并发症少、可重复施行等优点,是浅表性膀胱肿瘤的首选治疗方法。