简介：Anisodinewassynthesizedfrom3α-hydroxy-6β-acetyltropinein11steps.Laevorotaryisomerofanisodinewaspreparedfromtheasymmetricdihydroxylationofcompound10viatheosmiumcatalyzedprocessemployingp-chlorobenzoyldihydroquinidineasthechiralligands.

简介：Thisarticlesummarizestheachievementsoftheauthors'groupintheareaofbiocatalyst-catalyzedorganicreactionsinrecent10years.AstrainofGeotrichumsp.obtainedbyscreeninuiscapableofstereoselectlvelyreducinganumberofcarbonylcompounds.Inmanycases,thestermghemistryiscomplementarywiththatobtainedbybaker'syeast.Therefore,thismicroorganismprovidesausefulpathwaytothepreparationofalcoholeompoundswithspecificconfigurations.Ontheotherhand,anmmberofplantsoureeshavebeenscreenedforoxynitrilasesandthehydrocyanationreactionsofvariousarylcarboxalde-hydeshavebeeninvestigated.A'micro-aqueousreactionsystem'wasinvented,bywhichaserlesofnovelopticallyactivecyanohydrinswereprepared.Onthishasis,ahighthrough-putcomtimasousreactionsystemhasbeendesigned.Thispaperalsodeseribesexamplesofthesynthesesofbio-activecompoundsbyusingtheoptieallyactivecompoundsobtainedfromtheabovementionedcatalyticreactionsasprecursors.

简介：抗抑郁剂duloxetine(1)经由3-(dimethylamino)的不对称的转移加氢被准备-1-(thiophen-2-yl)propan-1-one(3)。Ru(II)，坚牢酸性蓝RH(III)和红外(III)几chiralligands的建筑群作为催化剂被检验并且(S，S)-N-tosyl-1,2-diphenyl乙烯肼(TsDPEN)Ru(II)建筑群被发现提供好产量和优秀enantioselectivity。

简介：Theasymmetricalkylationsofchiraltransitionmetalcomplexesderivedfrom(+)-camphorand2-aminomethyl-6-methylpyridinewereexaminedundermildconditions.Theformationofthecomplexes2isconductivetotheenhancementofdi-astereoselectivityinthealkylationsatroomtemperature.

简介：Eleven(S)-(-)-bishydrocarbyl-(1-alkanoylpyrrolidin-2-yl)-methanolderivativesofthreetypesweresynthesizedfromL-proline,asymmtricallyselectivealkylationproductswereobtainedbyLDAtreatmentandalkylationusingmethyl2-bromoethylether,andthreetypesofchiralα-substituted-γ-butyrolactoneswereobtainedbyhydrolyzingthealkylationproducts,with%e.e.beingupto89percent.

简介：Introduction.Poly(N-vinylcarbazole)(PVCZ)hasreceivedmuchattentionasarepresentativephotoconductivepolymerandextensivestudiesonmechanical,physical,chemicalandelectricalpropertieshavebeenreported'’.Ingeneral,thePVCZobtainedbyradicalandordinarycanonpolym...

简介：AC2-symmetricalaryldiphosphitederivedfromchiralbinaphtholwaspreparedanditsrhodiumcomplexwasusedascatalystsintheasymmetrichydroformylationofolefins.Highcatalyticactivityandgoodregioselectivitywereobserved.Upto31.2%eeand38.1%eewereachievedforthehydroformylationof4-fluoro-styreneandvinylacetaterespectively.Theinfluencesofligand-to-metalratio,reactiontemperatureandthepressureofsyn-gasontheenantioselectivityandregioselectivitywerealsostudied.

简介：Areusablecinchonaalkaloidderivativeligand,whichcouldbeeasilysynthesizedbytwosteptransformationwithcheap3,6-dichloropyridazineandquinineasmaterials,wasappliedtohomogeneousasymmetricdihydroxylationofolefinswithNMOasco-oxidantinMe2CO-H20systemandtheproductscouldbeextractedwithEt2Ofromtherecyclablecatalystsystem.80%---93%yieldand51%-99%eehavebeenobtained.Whentrans-stilbenewaschosenasthesubstrateforrecyclingexperiment,88%-92%yieldand>99%eehavebeenobtainedfortenrecycles.

简介：新奇不对称的alkylaminoborazine单体，2-propylamino-4,6-bis(methylamino)borazine，第一次，并且直接被综合给melt-spinnablepolyborazine(PBN)的polymerized。这不对称的alkylaminoborazine被2,4,6-trichloroborazine(TCB)的aminolysis反应在温和条件下面与不同的胺综合。这条线路结果比常规线路便宜得多、简单。化学作文，结构，分子的重量和陶器的产量被EA，FTIR，NMR，GPC和TG分析调查。PBN为融化旋转展出合适的rheological性质，它建议它是为BN纤维的一位潜在的先锋。

简介：Thechiralclusters(μ3-S)MCoW(CO)8[η^5-C5H4C(O)OCH3][M=Ru(2),Fe(3)]weresynthesizedbyasymmetricinductionofN-benzylcinchoniumchlorideasphase-transfercatalyst(PTC).ThemostsuitableamountofPTCis70mol%.Cluster3wasdeterminedbysinglecrystalX-raydiffractionanalysis.Thebesteeofthechiralclusterisover20%.

简介：Easilyavailablechiralketoneswereemployedforthesynthesisofopticallyactivepyridylalcohols,whichwereappliedintheasymmetricdiethylzincadditiontoaldehydes,upto89.4%e.e.wasobtainedusingD-fructose-derivedpyridylalcohol.

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简介：Bothenantiomersoffluoxetineweresynthesizedinfivestepsfromethylbenzoylacetate(1)usingmicrobial-chemicalapproachwithoverallyieldsof59%and62%respectively.(S)-Enan-tiomercanbeobtainedin>99%e.e.byrestingcellofbaker’syeastandtheRformwasproducedin81%e.e.byimmobilizedGeotrichumsp.G38.

简介：氨基甲酸酯，硫安类药剂和乙酰胺到的intramolecularorganocatalyticenantioselectiveaza-Michael反应，不饱和的酉同类被开发。这个过程被9-amino-9-deoxy-epi-quinine和diphenyl氢磷酸盐支持与优秀enantioselectivity(92%-97.5%ee)和很好的收益(多达99%)负担得起几综合地有用的五成员、六成员的heterocycles的直接、迅速的合成。

简介：EasilyavailableD-(+)-camphor-derivedchiralmercapto-alcohols2and3wereemployedforcatalyticasymmetricboranereductionofaromaticketones.Moderateenantioselectivitieswithe.e.20.2-72.1%wereobtainedwith10mol%catalyst.Oppositeasymmetricinductionwasachievedwhenmercapto-alcohols2and3wereused.

简介：Directasymmetricaldoladditionofmethylketonesto2,2,2-trifluoro-1-phenylethanoneanditsring-substitutedderivativeswasachievedusingL-prolineasachiralpromoter.Variousopticallyactiveβ-trifluoromethyl-β-hydroxyketoneswereobtainedinalmostquantitativeyieldswithmoderateenantioselectivitiesupto64%ee.

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简介：(-)-cis-1,3-Dibenzyl-hexahydrofuro[3,4-d]imidazole-2,4-dionewaspreparedbyanewsynthesismethodfrommesodicarboxylicacidanddehydroabietylaminebyasymmetricreductioningoodyieldwithupto91.6%e.e.value.

简介：乙醇2-的催化不对称的加氢的申请(benzo[b]thiophen-5-yl)为认知enhancerT-588的正式合成的-2-oxoacetate被描述。加氢作为添加剂与HCl在Ru-SunPhos系统的催化作用下面被进行。乙醇2-(benzo[b]thiophen-5-yl)-2-hydroxy-acetate与98.6%ee被获得，它能容易在简单再结晶以后被升级到99.5%ee并且在T-588的合成用作关键中介。