Objective:Toobservetheeffectofinhibitionoftelomeraseactivitybyseleniumdioxide(SeO2)onlungcarcinomacelllineGLC-82.Methods:TRAP-PCR-ELISAwasusedtostudythechangesoftelomeraseactivityinhumanpulmonaryadenocarcinomacelllineGLC-82treatedbySeO2atthedifferentconcentrations(3,10,30μmol/L)andfordifferenttimes(24,48,and72h).Results:SeO2inhibitedthetelomeraseactivityofGLC-82atthedifferentconcentrationsaftertreatmentof24,48and72h.Conclusion:SeO2inhibitsfromtelomeraseactivityofhumanlungcarcinomalineGLC-82.Theeffectofinhibitionisdose-dependantandtime-dependant.
