摘要
Computationalanalysisisessentialfortransformingthemassesofmicroarraydataintoamechanisticunderstandingofcancer.Herewepresentamethodforfindinggenefunctionalmodulesofcancerfrommicroarraydataandhaveappliedittocoloncancer.First,acoloncancergenenetworkandanormalcolontissuegenenetworkwereconstructedusingcorrelationsbetweenthegenes.Thenthemodulesthattendedtohaveahomogeneousfunctionalcompositionwereidentifiedbysplit-tingupthenetwork.Analysisofbothnetworksrevealedthattheyarescale-free.Comparisonofthegenefunctionalmodulesforcoloncancerandnormaltissuesshowedthatthemodules’functionschangedwiththeirstructures.
出版日期
2006年04月14日(中国期刊网平台首次上网日期,不代表论文的发表时间)