摘要
Thisreviewstartswithabriefhistoryofdrugdiscovery&development,andtheplaceofAsiainthisworldwideeffortdiscussed.TheconditionsandconstraintsofasuccessfultranslationalR&DinvolvingacademicbasicresearchandclinicalresearcharediscussedandtheSingaporemodelforpursuitofopenR&Ddescribed.Theimportanceofwell-characterized,validateddrugtargetsforthesearchfornoveltargetedanti-canceragentsisemphasized,aswellasastructured,highqualitytranslationalR&D.Furthermore,thecharacteristicsofanattractivepreclinicaldevelopmentdrugcandidatearediscussedlayingthefoundationofasuccessfulpreclinicaldevelopment.Themostfrequentsourcesoffailuresaredescribedandriskmanagementateverystageishighlyrecommended.Organizationalfactorsarealsoconsideredtoplayanimportantrole.Thefactorstoconsiderbeforestartinganewdrugdiscovery&developmentprojectaredescribed,andanexampleisgivenofasuccessfulclinicalprojectthathashaditsrootsinlocaluniversitiesandwascarriedthroughpreclinicaldevelopmentintophaseIclinicaltrials.
出版日期
2015年04月14日(中国期刊网平台首次上网日期,不代表论文的发表时间)