Phosphate Glass Fibre Composites for Bone Repair

在线阅读 下载PDF 导出详情
摘要 Weinvestigatehigh-modulusdegradablematerialsintendedtoreplacemetalsinbiomedicalapplications.Thesearetypicallycompositescomprisingapolylactide(PLA)matrixreinforcedwithphosphateglassfibres,whichprovidereinforcementsimilartoE-glassbutareentirelydegradableinwatertoproduce,principally,calciumphosphate.Wehavemadecompositesusingavarietyoffibrearchitectures,fromnon-wovenrandommatstounidirectionalfibretapes.Flexuralpropertiesintheregionof30GPamodulusand350MPastrengthhavebeenachieved-directlycomparabletoquotedvaluesforhumancorticalbone.Incollaborationwithothergroupswehavebeguntoconsiderthedevelopmentoffoamedsystemswithstructuresmimickingcancellousboneandthishasshownsignificantpromise.Thefibresinthesefoamedstructuresprovideimprovedcreepresistanceandreinforcementoftheporewalls.Todatethematerialshaveexhibitedexcellentcellularresponsesinvitroandfurtherstudiesareduetoincludeconsiderationofthesurfacecharacterofthematerialsandtheinfluenceofthisoncellinteraction,bothwiththecompositesandtheglassfibresthemselves,whichshowpromiseasastandaloneporousscaffold.
机构地区 不详
出版日期 2009年04月14日(中国期刊网平台首次上网日期,不代表论文的发表时间)
  • 相关文献