简介:Thequestforneuroprotectivedrugstoslowtheprogressionofneurodegenerativediseases(NDDs),includingAlzheimer'sdisease(AD),Parkinson'sdisease(PD),andHuntington'sdisease(HD),hasbeenlargelyunrewarding.Preclinicalevidencesuggeststhatrepurposingquetiapine,lithium,valproate,fluoxetine,donepezil,andmemantineforearlyandpre-symptomaticdisease-modificationinNDDsmaybepromisingandcanspareregulatorybarriers.Theliteratureofthesepsychotropicsinearlystageandpre-symptomaticAD,PD,andHDisreviewedandpropitiousfindingsfollow.Mildcognitiveimpairment(MCI)phaseofAD:salutaryhumanrandomizedcontrolledtrialfindingsforlow-doselithiumand,inselectedpatients,donepezilawaitreplication.Pre-symptomaticAD:humanepidemiologicaldataindicatethatlithiumreducesADrisk.Animalmodelstudies(AMS)revealencouragingresultsforquetiapine,lithium,donepezil,andmemantine.EarlyPD:valproateAMSfindingsshowpromise.Pre-symptomaticPD:lithiumandvalproateAMSfindingsareencouraging.EarlyHD:uncontrolledclinicaldataindicatenon-progressionwithlithium,fluoxetine,donepezil,andmemantine.Pre-symptomaticHD:lithiumandvalproateareauspiciousinAMS.Manyotherpromisingfindingsawaitingreplication(valproateinMCI;lithium,valproate,fluoxetineinpre-symptomaticAD;lithiuminearlyPD;lithium,valproate,fluoxetineinpre-symptomaticPD;donepezilinearlyHD;lithium,fluoxetine,memantineinpre-symptomaticHD)arereviewed.Dose-andstage-dependenteffectsareconsidered.Suggestionsforsignal-enhancementinhumantrialsareprovidedforeachNDDstage.
简介:摘要:目的:对口腔正畸科5S管理中三维数字化牙颌模型的应用效果进行分析。方法:本次实验对象为口腔畸形患者,共计82例,本次实验在2019年7月初开始实施,正式结束时间为2021年5月。随机编号结果的奇偶性为本次实验的分组依据,对照组患者采取牙膏牙颌模型,实验组患者采取三维数字化牙颌模型,两组均实施5S管理,对两组患者模型精准度、模型遗失率、有效使用率、器械规范放置率进行对比分析。结果:深入分析本次实验,对照组及实验组患者模型精准度、模型遗失率、有效使用率、器械规范放置率之间均存在着较大的差距,组间差异凸显,(p<0.05)。结论:在口腔正畸科5S管理中三维数字化牙颌模型有着较高的应用价值,其在提高医护工作水平及空间利用率等方面表现优异。
简介:Thispaperconstructedportfoliosaccordingtothegrowthratesandtheirstabilityoffirm'stotalstockholders'equitypershareandnetincomepershare,usingallthefirms'informationofShanghaiA-sharemarket.Wefoundthatthemarketexhibitssomeoverreactiontothegrowthraieoffirm'snetincomepershare,andisn'tsensitivetothestabilityoffirm'sgrowthrates.
简介:TheU.S.-drivenTPPhascaughttheattentionoftheregionandisbringinguncertaintytoEastAsianeconomicintegration.China,theU.S.andJapanhavetakendifferentpositionsontheTPPitself.TheU.S.isactivelyparticipatinginTPPnegotiationsandtryingtodominateit.JapanregardstheTPPasatoolwithwhichitcanfurtherexploremarketsaswellasstrengthenitsrelationshipwiththeU.S..ChinaiscurrentlyassessingtheU.S.shiftineconomicstrategytowardsEastAsiaandthepotentialimpactsofTPPexpansion.
简介:NatsumeSōseki(1867-1916)sufferedfromcyclicmentaldepressionsthroughhislife,anditwaswhenhewasinthestateofthemostterribleonethathestartedhiscareerasawriterbywritingIAmaCat(1905-1906).TherearesomeevidencebyhiswifeandfriendsthatSōseki’sconditionofdiseasedramaticallyimprovedduringitsserializationonamagazine,andthewriterhimselfadmitedhumorouslyintheprefaceofotherworkthatitwashisdepressionandmaniathatenabledhimtoproduceIAmaCatandotherearlyworks.Thispaperaimsatdescribingtheprocesshowhisactofnarratinghadtherapeuticeffectsonhisstateofmindfocusingontheconstructionofcomplicitousrelationshipbetweenanimpliedauthorandreadersintheworkbytheuniquefunctionsofthefirst-‘person’narrator:ACat.Amongothers,IwillconsidertheinfluenceofLaurenceSterne’sTristramShandy(1759-1767),whichSōsekiintroducedtoJapanforthefirsttime,bydiscussingthefrequentuseofmetalepsisthatthetwoworkshaveincommon.
简介:学校变革是教育改革的突破口与落脚点。大学与中小学在政府的支持保障或促成下进行合作的U-G-S模式具有重要意义,然而其局限也很明显:投入多、见效慢,理论研究者与实践者交流不畅。U-G-S-S模式承继了U-G-S模式的优势,并进行了突破:强调参与学校变革行动的中小学的数量为两所及以上,且学校教育质量是异质的,既有城市优质学校,也有城郊薄弱学校或乡村学校;U-G-S-S四方主体平等互动、各司其职。个案研究表明,U-G-S-S模式可以通过制度建构、任务驱动和文化营造促进各参与学校的整体发展,促进城乡义务教育均衡发展。U-G-S-S模式成功的三个主要要素:文化异质交融、知识多维共享、理论实践有机结合。