简介：无

简介：AbstractBackground:Computed tomography images are easy to misjudge because of their complexity, especially images of solitary pulmonary nodules, of which diagnosis as benign or malignant is extremely important in lung cancer treatment. Therefore, there is an urgent need for a more effective strategy in lung cancer diagnosis. In our study, we aimed to externally validate and revise the Mayo model, and a new model was established.Methods:A total of 1450 patients from three centers with solitary pulmonary nodules who underwent surgery were included in the study and were divided into training, internal validation, and external validation sets (n = 849, 365, and 236, respectively). External verification and recalibration of the Mayo model and establishment of new logistic regression model were performed on the training set. Overall performance of each model was evaluated using area under receiver operating characteristic curve (AUC). Finally, the model validation was completed on the validation data set.Results:The AUC of the Mayo model on the training set was 0.653 (95% confidence interval [CI]: 0.613-0.694). After re-estimation of the coefficients of all covariates included in the original Mayo model, the revised Mayo model achieved an AUC of 0.671 (95% CI: 0.635-0.706). We then developed a new model that achieved a higher AUC of 0.891 (95% CI: 0.865-0.917). It had an AUC of 0.888 (95% CI: 0.842-0.934) on the internal validation set, which was significantly higher than that of the revised Mayo model (AUC: 0.577, 95% CI: 0.509-0.646) and the Mayo model (AUC: 0.609, 95% CI, 0.544-0.675) (P < 0.001). The AUC of the new model was 0.876 (95% CI: 0.831-0.920) on the external verification set, which was higher than the corresponding value of the Mayo model (AUC: 0.705, 95% CI: 0.639-0.772) and revised Mayo model (AUC: 0.706, 95% CI: 0.640-0.772) (P < 0.001). Then the prediction model was presented as a nomogram, which is easier to generalize.Conclusions:After external verification and recalibration of the Mayo model, the results show that they are not suitable for the prediction of malignant pulmonary nodules in the Chinese population. Therefore, a new model was established by a backward stepwise process. The new model was constructed to rapidly discriminate benign from malignant pulmonary nodules, which could achieve accurate diagnosis of potential patients with lung cancer.

简介：AbstractBackground:Rebleeding can cause a catastrophic outcome after aneurysmal subarachnoid hemorrhage. A clinical + morphology nomogram was promoted in our previous study to assist in discriminating the rupture intracranial aneurysms (RIAs) with a high risk of rebleeding. The aim of this study was to validate the predictive accuracy of this nomogram model.Method:The patients with RIAs in two medical centers from December 2020 to September 2021 were retrospectively reviewed, whose clinical and morphological parameters were collected. The Cox regression model was employed to identify the risk factors related to rebleeding after their admission. The predicting accuracy of clinical + morphological nomogram, ELAPSS score and PHASES score was compared based on the area under the curves (AUCs).Results:One hundred thirty-eight patients with RIAs were finally included in this study, 20 of whom suffering from rebleeding after admission. Hypertension (hazard ratio (HR), 2.54; a confidence interval of 95% (CI), 1.01-6.40; P = 0.047), bifurcation (HR, 3.88; 95% CI, 1.29-11.66; P = 0.016), and AR (HR, 2.68; 95% CI, 1.63-4.41; P < 0.001) were demonstrated through Cox regression analysis as the independent risk factors for rebleeding after admission. The clinical + morphological nomogram had the highest predicting accuracy (AUC, 0.939, P < 0.01), followed by the bifurcation (AUC, 0.735, P = 0.001), AR (AUC, 0.666, P = 0.018), and ELAPSS score (AUC, 0.682, P = 0.009). Hypertension (AUC, 0.693, P = 0.080) or PHASES score (AUC, 0.577, P = 0.244) could not be used to predict the risk of rebleeding after admission. The calibration curve for the probability of rebleeding showed a good agreement between the prediction through clinical + morphological nomogram and actual observation.Conclusion:Hypertension, bifurcation site, and AR were independent risk factors related to the rebleeding of RIAs after admission. The clinical + morphological nomogram could help doctors to identify the high-risk RIAs with a high predictive accuracy.

简介：AbstractBackground:Delayed graft function (DGF) is the main cause of renal function failure after kidney transplantation. This study aims at investigating the value of hypothermic machine perfusion (HMP) parameters combined with perfusate biomarkers on predicting DGF and the time of renal function recovery after deceased donor (DD) kidney transplantation.Methods:HMP parameters, perfusate biomarkers and baseline characteristics of 113 DD kidney transplantations from January 1, 2019 to August 31, 2019 in the First Affiliated Hospital of Xi’an Jiaotong University were retrospectively analyzed using univariate and multivariate logistic regression analysis.Results:In this study, the DGF incidence was 17.7% (20/113); The multivariate logistic regression results showed that terminal resistance (OR: 1.879, 95% CI 1.145-3.56) and glutathione S-transferase (GST)(OR = 1.62, 95% CI 1.23-2.46) were risk factors for DGF; The Cox model analysis indicated that terminal resistance was an independent hazard factor for renal function recovery time (HR = 0.823, 95% CI 0.735-0.981). The model combining terminal resistance and GST (AUC = 0.888, 95% CI: 0.842-0.933) significantly improved the DGF predictability compared with the use of terminal resistance (AUC = 0.756, 95% CI 0.693-0.818) or GST alone (AUC = 0.729, 95% CI 0.591-0.806).Conclusion:According to the factors analyzed in this study, the combination of HMP parameters and perfusate biomarkers displays a potent DGF predictive value.

简介：Thispaperpresentsanextendedmodelpredictivecontrollerformaximizingtheabsorbedpowerofapointabsorberwaveenergyconverter.Owingtothegreatinfluenceofcontrollerparametersupontheabsorbedpower,theoptimizationoftheseparametersiscarriedoutforthefirsttimebyafireflyalgorithm(FA).Error,thedifferencebetweenoutputvelocityofbuoyandinputwavespeedwhichleadstopowermaximizationintheoptimizedMPCiscomparedwiththeclassicalMPC.Simulationresultsindicatethatgiventhehighaccuracyandacceptablespeedofthealgorithm,itcanadjusttheparametersofthecontrollertothepointwheresystemerrordecreasedeffectivelyandtheabsorbedenergyincreasedabout4MW.

简介：在加热，通气并且空气调节(HVAC)系统，在那里存在严重非线性，变化时间的性质，骚乱和无常。新预兆的功能的控制基于Takagi-Sugeno(T-S)，模糊模型被建议控制HVAC系统。稳定的控制过程的T-S模糊模型用最少的广场方法被获得，然后，根据从T-S模糊模型，的全球线性预兆的模型，这个过程被预兆的功能的控制器控制。特别反馈规定部分被开发补偿模糊预兆的模型的无常。最后，在HVAC系统控制应用程序的模拟测试结果证明预兆的功能的控制改进追踪的建议模糊模型完成并且坚韧性。与常规PID控制器相比，这控制策略有更少的优点射并且更短的背景时间，等等。关键词T-S模糊模型-预兆的功能的控制-最少的广场方法-HVAC系统这个工作被中国(号码031B5147)的山东省的年轻科学家基本研究节目支持。收到的HongliL眉她在在2000的数学的学士，和在从Qufu师范大学的在2003的控制理论的硕士分别地。自从2003年8月，她是控制科学和工程学校的一个博士候选人，山东大学。自从2006年3月，她是EEE学校的一个访问学者，Nanyang工艺的大学。她的搜索兴趣包括模糊控制系统理论和应用程序，为预兆的控制建模，非线性的multivariable控制系统，等等。花环JIA当前是控制科技的学院的头，山东大学，中国。他收到了B.Eng。在自动化的度和在从山东工业大学设计的控制的M.Eng学位，中国在1982和1988，分别地，并且在来自浙江大学的控制理论和控制工程的博士学位，中国，在1991。正弦1995，他是在山东的一个教授大学。他的当前的研究兴趣包括人工的聪明、聪明的控制，柔韧的控制，非线性的进程控制理论和应用程序。ShulanKONG是在数学科学的学校的一个副教授，Qufu师范大学。她分别地在1995和2004从Qufu师范大学和山东

简介：BackgroundThecoronarycollateralcirculationhasapositiveeffectontheischemicmyocardium.Butitislimitedforpatientsmissingthetimewindowoftotalocclusionofthecoronaryarteryelectivepercutaneouscoronaryintervention(PCI).Theeffectofcollateralcirculationonleftcardiacfunctionhasbeenlessstudied.MethodsAtotalof34patientswithoneormorecoronaryarteryocclusionwhounderwentcoronaryangiographyandRentrop'smethodweredividedinto2groups:Goodcollateralcirculation(Agroups,Rentropscore2-3,n=19)and(Bgroups,Rentropscore1-2,n=15).Theimprovementofleftventricularenddiastolicvolume(LVEDV)andleftventricularejectionfraction(LVEF)werecomparedbetweenthetwogroupsbeforeandafterPCI.ResultsIngoodcollateralcirculationgroup,leftventricularejectionfraction(LVEF)wassignificantlyhigherafterPCI(P<0.05).Inpoorcollateralcirculationgroup,leftventricularenddiastolicvolumeindex(LVEDV)wassignificantlyincreasedafterPCI(P<0.05).ConclusionsGoodcollateralcirculationhasasignificantprotectiveeffectonleftventricularfunction.PCIoperationcansignificantlyimprovetheprognosisofpatientswithgoodcollateralcirculationofcoronaryarteryocclusion.

简介：Objective:Toassesstheresponserateofpatientswithrectaladenocarcinomatoneoadjuvanttherapyandtoidentifythepredictorsofhistologicalregressionafterneoadjuvantradiotherapy(RT)orconcurrentchemoradiotherapy(CCRT).Methods:Thisstudyrecruited64patients.Thepatientshadresectablecancerofthelowerandthemiddlerectum(T3/T4and/orN+)withoutdistantmetastasisandreceivedneoadjuvantRTorCCRTfollowedbyradicalsurgerywithtotalmesorectalexcision(TME)betweenJanuary2006andDecember2011.Thepatientswereclassifiedintonon-response(NR),partialresponse(PR),andpathologiccompleteresponse(pCR)basedontheDworaktumorregressiongradingsystem.Results:Themedianageofpatientswas57years(rangingfrom22to85).Atotalof24patientsweretreatedwithneoadjuvantCCRT,whereas40patientsweretreatedwithRTalone.Abdominoperinealresection(APR)wasperformedon29patients(45%).AnteriorresectionwithTMEwasperformedon34patients(53%).Onepatienthadlocalresection.Histologically,12(19%),24(73%),and28(44%)patientsexhibitedpCR,PR,andNR,respectively.Univariateanalysisrevealedthatthepredictorsoftumorregressionwereasfollows:theabsenceoflymphnodeinvolvementfrominitialimaging(cN0)(P=0.021);normalinitialcarcinoembryonicantigen(CEA)level(P=0.01);hemoglobinlevel≥12g/dl(P=0.009);CCRT(P=0.021);andtumordownstaginginimaging(P=0.001).MultivariateanalysisshowedthatthemainpredictorsofpCRwereCTcombinedwithneoadjuvantRT,cN0stage,andtumorregressiononimaging.Conclusions:IdentifyingthepredictorsofpCRfollowingneoadjuvanttherapyaidstheselectionofresponsivepatientsfornonaggressivesurgicaltreatmentandpossiblesurveillance.

简介：Purpose:Anumberofdifferentclinicalcharacteristicshavebeenreportedtosinglycorrelatewiththerapeuticactivityofepidermalgrowthfactorreceptor(EGFR)tyrosinekinaseinhibitors(TKIs)inadvancednon-small-celllungcancer(NSCLC).Thisstudyaimedtoidentifypredictivefactorsassociatedwithprognosticbenefitsofgefitinib.Patientsandmethods:EGFRgenetypingin33advancedNSCLCpatientsreceivedgefitinib(250mg/day)wereanalyzedwithmutant-enrichedPCRassay.Gefitinibresponsewasevaluatedwithpotentialpredictivefactorsretrospectively.Results:Theoverallobjectiveresponserate(ORR)andmedianprogression-freesurvival(PFS)inthe33patientstreatedbygefitinibwere45.5%and3.0(2.0-4.0)months.TheORRandmedianPFSinEGFRgenemutationpatientsweresignificantlyhigher/longerthanthoseinEGFRgenewild-typepatients(P<0.01).Similarly,theORRandmedianPFSinnon-smokerpatientsweresignificantlyhigher/longerthanthoseinsmokerpatients(P<0.05,P<0.01,respectively).However,nodifferenceforORRandmedianPFSoccurredbetweenmaleandfemalepatients.LogisticmultivariateanalysisshowedthatonlyEGFRmutatedgenewassignificantlyassociatedwiththeORR(P<0.01).BothEGFRmutatedgeneandnon-smokerwerethemajorfactorsthatcontributedtoPFS(P<0.05).Conclusions:EGFRmutatedgeneandnon-smokerstatusarepotentialpredictorsforgefitinibresponseinNSCLCpatients.

简介：在这篇论文，一个线性编程方法被建议解决模型为混合系统的一个类的预兆的控制。第一，使用(最大，+)代数学，称为max-plus-linear(MPL)系统的混合系统的一个典型子类被获得。然后，模型预兆的控制(MPC)框架被扩大到MPL系统。一般来说，非线性的优化途径或扩大线性补充问题(ELCP)被使用解决MPL-MPC优化问题。一个新优化方法基于为max-min-plus-scaling(MMPS)的正规形式工作(用操作最大化，最小化，增加和分级的增加)与输入上的线性限制被介绍。建议途径在解决几个线性编程问题在于并且比非线性的优化更有效。算法的有效性被一个例子说明。关键词混合系统-Max-plus-linear系统-为预兆的控制建模-正规形式-Max-min-plus-scaling功能-线性编程这个工作被中国(号码60474051)和程序的国家科学基金在中国(NCET)的大学里为新世纪优秀才能支持。邹元元在1980出生了，Yantai，中华人民共和国。她是在上海JiaoTong大学的一个博士候选人。她的研究兴趣包括预兆的控制，混合系统等等。李绍元在1965出生了，Hebei，中华人民共和国。他在1997从Nankai大学的计算机和系统科学的系收到了他的博士学位。现在他是自动化的研究所的一个教授，上海JiaoTong大学。他的研究兴趣包括模糊系统，非线性的系统控制等等。

简介：Enlargedvestibularaqueduct(EVA),themostfrequentidentifiablecauseofcongenitalhearingloss,isevaluatedwithhigh-definitionmultidetectorCTintheaxialplane.OurpurposewastodeterminewhichreformattedCTmeasurementsaremostreproducible.Sevenmultiplanarreformattedimageswerecreatedforeachofthe64temporalbonesinpatientswithEVA.Intraclasscorrelationcoefficients(ICC)wereusedtoassessinter-observervariability,andbothlinearregressionandROCanalyseswereusedtocomparethemeasurementswithseverityofhearingloss,asassessedbypuretoneaudiometry.Allsevenmeasurementshadexcellentinter-observervariability,withaverage-measureICCrangingfrom0.92to0.98.Therewasnostatisticallysignificantcorrelationbetweentheradiologicdegreeofaqueductenlargementandseverityofhearinglossusinganyofthesevenmeasurements;ROCanalysesrevealedareasunderthecurvesrangingfrom0.57to0.73.Optimalaccuracywasobtainedwithathresholdof1.75mmasmeasuredattheaqueductalapertureintheP€oschlplane,withsensitivityof0.75andspecificityof0.63.AlthoughtheradiologicmeasurementmaynotserveasareliabletoolforassessingseverityofEVA,P€oschlplanereformattinghasproventobebetterthanconventionalaxialacquisitionplaneforidentifyingpatientswithclinicallysignificanthearingloss.

简介：无

简介：Thispaperproposesamultiple-constraints-guaranteedmidcourseguidancelawfortheinterceptionofthehypersonictargets.Intraditionalmidcourselawdesign,theconstraintsoftheaero-thermalheatingarerarelytakenintoconsideration.Theperformanceoftheinfrareddetectionsystemmaybedegradedandtheinstabilityoftheflightcontrolsystemmaybeinduced.Toaddressthisproblem,astate-constrainedmodelpredictivestaticprogrammingmethodisintroducedsuchthatbothterminalconstraints(positionandangle)andoptimalenergyconsumptioncanbeensured.Asaresult,asub-optimalmidcourseguidance,guaranteeingtheaforementionedmultiple-constraintstobeneverviolated,issynthesized.Simulationresultsdemonstratetheeffectivenessoftheproposedmethod.

简介：AbstractBackground:The basis of individualized treatment should be individualized mortality risk predictive information. The present study aimed to develop an online individual mortality risk predictive tool for acute-on-chronic liver failure (ACLF) patients based on a random survival forest (RSF) algorithm.Methods:The current study retrospectively enrolled ACLF patients from the Department of Infectious Diseases of The First People’s Hospital of Foshan, Shunde Hospital of Southern Medical University, and Jiangmen Central Hospital. Two hundred seventy-six consecutive ACLF patients were included in the present study as a model cohort (n = 276). Then the current study constructed a validation cohort by drawing patients from the model dataset based on the resampling method (n = 276). The RSF algorithm was used to develop an individual prognostic model for ACLF patients. The Brier score was used to evaluate the diagnostic accuracy of prognostic models. The weighted mean rank estimation method was used to compare the differences between the areas under the time-dependent ROC curves (AUROCs) of prognostic models.Results:Multivariate Cox regression identified hepatic encephalopathy (HE), age, serum sodium level, acute kidney injury (AKI), red cell distribution width (RDW), and international normalization index (INR) as independent risk factors for ACLF patients. A simplified RSF model was developed based on these previous risk factors. The AUROCs for predicting 3-, 6-, and 12-month mortality were 0.916, 0.916, and 0.905 for the RSF model and 0.872, 0.866, and 0.848 for the Cox model in the model cohort, respectively. The Brier scores were 0.119, 0.119, and 0.128 for the RSF model and 0.138, 0.146, and 0.156 for the Cox model, respectively. The nonparametric comparison suggested that the RSF model was superior to the Cox model for predicting the prognosis of ACLF patients.Conclusions:The current study developed a novel online individual mortality risk predictive tool that could predict individual mortality risk predictive curves for individual patients. Additionally, the current online individual mortality risk predictive tool could further provide predicted mortality percentages and 95% confidence intervals at user-defined time points.

简介：AIM:Toevaluatetheepidemiologyandoutcomesofculture-positivespontaneousbacterialperitonitis(SBP)andspontaneousbacteremia(SB)indecompensatedcirrhosis.METHODS:Weprospectivelycollectedclinical,laboratorycharacteristics,typeofadministeredantibiotic,susceptibilityandresistanceofbacteriatoantibioticsinonehundredthirtycases(68.5%males)withpositiveasciticfluidand/orbloodculturesduringtheperiodfromJanuary1,2012toMay30,2014.AllpatientswithSBPhadpolymorphonuclearcellcountinasciticfluid>250/mm3.InpatientswithSBathoroughstudydidnotrevealanyothercauseofbacteremia.Thepatientswerefollowed-upfora30-dperiodfollowingdiagnosisoftheinfection.Thefinaloutcomeofthepatientswasrecordedintheendoffollow-upandcomparisonamong3groupsofpatientsaccordingtothepatternofdrugresistancewasperformed.RESULTS:Gram-positive-cocci(GPC)werefoundinhalfofthecases.ThemostprevalentorganismsinadescendingorderwereEscherichiacoli(33),Enterococcusspp(30),Streptococcusspp(25),Klebsiellapneumonia(16),S.aureus(8),Pseudomanasaeruginosa(5),otherGram-negative-bacteria(GNB)(11)andanaerobes(2).Overall,20.8%ofisolatesweremultidrug-resistant(MDR)and10%extensivelydrugresistant(XDR).Health-care-associated(HCA)and/ornosocomialinfectionswerepresentin100%ofMDR/XDRandin65.5%ofnon-DRcases.MeropenemwastheempiricallyprescribedantibioticinHCA/nosocomialinfectionsshowingadrug-resistancerateof30.7%whilethirdgenerationcephalosporinsof43.8%.MeropenemwasineffectiveonbothXDRbacteriaandEnterococcusfaecium(E.faecium).AllbutoneXDRweresusceptibletocolistinwhileallGPC(includingE.faecium)andthe86%ofGNBtotigecycline.Overall30-dmortalitywas37.7%(69.2%forXDRand34.2%fortherestofthepatients)(logrank,P=0.015).Inmultivariateanalysis,factorsadverselyaffectingoutcomeincludedXDRinfection(HR=2.263,95%CI:1.005-5.095,P=0.049),creatinine(HR

简介：Thispaperdealswiththedesignofanoutputfeedbackpredictivecontrollerforinductionmotors.Thefundamentalinterestoftheproposedcontrolleristhecapabilityofdecouplingthemechanicalspeedandtherotorfluxes,withoutdegradationagainstthevariationofrotorresistanceandloadtorque.Hence,thecontributionistoapplytwoestimationproceduresinordertoachievethisgoal.Namely,anunknowninputobserver（UIO）isusedfortheconstanttimeestimationwhereasaheuristicsolutionisexploitedfortheloadtorqueupdate.Moreover,rotorfluxcomponentsarerecoveredasanunavailablestateofthesystem.Effectivenessoftheproposedobserversandtheperformanceofthecontrollerareconfirmedbysimulationresults.

简介：Mineralisationistheresultofthecoupledmulti-geodynamicprocessesinthecrust.Thecoupledmechano-thermo-hydrological(MTH)processesarethebasicphysicalprocessesthatgovernthelocationofthehydrothermalmineralization,whichcanbesimulatedinthecomputerbyusingofthenumericalcodes,suchasFLAC.Thenumericalmodelingresultscanbeusednotonlytoexplainthefeaturesofexistingoredeposits,butalsotopredictthefavorablemineralizationlocations.ThispaperhassummarizedthebasicequationsdescribingcoupledMHTprocessesinthewater-saturatedporousrocks,theprinciplesofFLAC,anditsapplicationtotheMHTprocessesrelatedtocoppermineralizationintheFenghuangshanorefield.WeusedtheFLACtosimulatethesyn-deformationcoolingandfluidflowingevolutionaftertheintrusionwasemplacedandsolidified.Themodelingresultssuggestamostprospectiveexplorationareawherethesubsequentexplorationsupportedthepredictionandthetestboreholedisclosedthehighqualitycopperorebodiesinthetarget,demonstratingapositiveroleofthenumericalMTHmodelinginfacilitatingpredictiveorediscovery.

简介：BackgroundMonocytetohighdensitylipoproteinratio(MHR)hasbeenconsideredasanovelparameterrelatedwithadverserenalandcardiovascularoutcomes.InthisstudyweinvestigatedtheassociationofMHRwithmajoradverseclinicalevents(MACEs)inpatientswithtype2diabetesmellitus(T2DM)undergoingelectivepercutaneouscoronaryintervention(PCI).MethodsConsecutiveT2DMpatientstreatedwithelectivePCIwereprospectivelyrecruitedbetweenJuly2008-January2016inDepartmentofCardiologyofPanyuCentralHospital.Subjectswerecategorizedintotwogroups:aspatientswhodevelopedMACEs(MACEs+)andpatientswhodidnotdevelopMACEs(MACEs-)duringhospitalization.MACEsweredefinedasthecompositeendpoints,includingall-causemortality,oracuteheartfailure,ortargetvesselrevascularization,orstrokeorrecurrentangina.ResultsAtotalof418patientswereincludedinthestudy.64patientsdevelopedMACEs(15.3%).IntheMACEs(+)patients,monocyteswerehigher(1.12[0.78-1.42]vs.0.72[0.68-0.92]109/L,P<0.01)andHDLcholesterollevelswerelower(0.87[0.72-1.21]vs.0.96[0.81-1.11]mmol/L,P<0.01).Inaddition,MHRwassignificantlyhigherintheMACEs(+)group(1.12[0.91-2.09]vs.0.73[0.54-0.93]109mmol/L,P<0.01).ThecutoffvalueofMHRforpredictingMACEswas22,withasensitivityof81%andaspecificityof75.1%(areaunderthecurve0.79,P<0.001).Inmultivariatelogisticregressionanalysis,MHRremainedanindependentfactorcorrelatedwithMACEs(OR=3.97,95%CI=1.38-11.5,P<0.01).ConclusionHigherMHRlevelsmaypredictMACEsdevelopmentafterelectivePCIinT2DMpatients.

简介：无

简介：Objective:Theepidermalgrowthfactorreceptor(EGFR)inhibitorsmonoclonalantibodies(MoAbs)havealreadyshownthetherapeuticeffectivenessinpatientswithmetastaticcolorectalcancer(mCRC).Butmanypatientsresisttothetreatment.Theaimofthismeta-analysiswastoassessEGFRgenecopynumber(GCN)asacandidatepredictivebiomarkerforresistancetoanti-EGFRMoAbsinmCRCtreatment.Methods:SystematiccomputerizedsearchesofthePubMed,EMBaseandCochraneLibrarywereperformed.Theprimaryendpointwasobjectiveresponserate(ORR).Thesecondendpointsincludedprogression-freesurvival(PFS),andoverallsurvival(OS).Thepooledoddratio(OR)andpooledsensitivity,specificity,andsummaryreceiveroperatorcharacteristic(SROC)forORRwereestimated.Thepooledhazardratios(HR)forPFSandOSwerealsocalculated.Results:Fourteenstudieswith1,021patientswereincluded.IncreasedEGFRGCNwasassociatedwithincreasedORR(OR=6.905;95%CI:4.489-10.620).Itwasalsofoundinwild-typeKRASmCRCpatients,withthepooledORof8.133(95%CI:4.316-15.326).GCNhasmediumvalueforpredictingORR,withthepooledsensitivityof0.79(95%CI:0.73-0.84),thepooledspecificityof0.59(95%CI:0.55-0.62).InwildtypeKRASmCRCpatients,thesensitivityandthespecificitywere0.80(95%CI:0.70-0.87)and0.60(95%CI:0.53-0.66),respectively.IncreasedEGFRGCNwasassociatedwithincreasedPFS(HR=0.557;95%CI:0.382-0.732)andOS(HR=0.579;95%CI:0.422-0.737).Conclusions:Thismeta-analysissuggeststhatEGFRGCNrepresentsapredictivebiomarkerfortumorresponseinmCRCpatientstreatedwithMoAbsregardlessofKRASmutation.mCRCpatientswithincreasedEGFRGCNaremorelikelytohaveabetterresponse,PFS,andOSwhentreatedwithcetuximaborpanitumumab.