简介:PURPOSE:ThisphaseⅡtrialwasdesignedtodefinetheroleofO^6-benzylguanine(O^6-BG)inrestoringtemozolomidesensitivityinpatientswithrecurrentorprogressive,temozolomidc-resistantmalignantgliomaandtoevaluatethesafetyofadministeringO^6-BGincombinationwithtemozolomide.PATIENTSANDMETHODS:Patientswereaccruedintotwoindependentstrataonthebasisofhistology:glioblastomamultifonne(GBM)andaanaplasticglioma.BothtemozolomideandO6-BGwereadministeredonday1ofa28-daytreatmentcycle.Patientswereadministereda1-hourO^6-BGinfusionatadoseof120mg/m^2followedimmediatelybya48-hourinfusionatadoseof30mg/m^2/d.
简介:PURPOSE:Toevaluatesingle-agentactivityofbevacizumabinpatientswithrecurrentglioblastoma.PATIENTSANDMETH-ODS:Patientswithrecurrentglioblastomaweretreatedwithbevacizumab10mg/kgevery2weeks.Aftertumorprogression,patientswereimmediatelytreatedwithbevacizumabincombinationwithirinotecan340mg/m^2or125mg/m^2every2weeks,dependingonuseofenzyme-inducingantiepilepticdrugs.Completepatientevaluationswererepeatedevery4weeks.RESULTS:Forty-eightheavilypretreatedpatientswereaccruedtothisstudy.Thromboembolicevents(12.5%),hypertension(12.5%),hypophosphatemia(6%),andthrombocytopenia(6%)werethemostcommondrug-associatedadverseevents.Sixpatients(12.5%)wereremovedfromstudyfordrug-associatedtoxicity(fivethromboembolicevents,onebowelperforation).
简介:PURPOSE:Fotemustineisanitrosoureacompoundusedforthetreatmentofmalignantgliomas,especiallyinFrance.Recently,anEORTC-NCICstudyhasshownthataconcomitantcombinationofradiotherapyplustemozolomide(anoralcytotoxicdrug)improvedsurvivalinglioblastomapatients.Wesetouttotestaconcurrentcombinationofradiotherapyandfotemustinefornewlymalignantgliomas.
简介:BACKGROUND:SupratentorialPNET(sPNET)arerareCNStumorsofembryonaloriginarisinginchildrenandadults.Thetreat-mentofsPNETforallagegroupsatourcancercenterhasbeenbasedonthemanagementofmedulloblastoma(MB),involvingneurosurgicaldebulkingfollowedbyeranio-spinalirradiation(CS1)andsystemicchemotherapy.METHODS:MedicalrecordswerereviewedtogatherdemographicandclinicaldataaboutallembryonalCNStumorsinchildrenandadultsfrom2001to2007.Tumorpathology,clinicalmanagementandsurvivaldatawerealsoassessed,particularlyasregardsthosepatientswhoreceivedthePackerchemotherapyregimenforeithersPNETorMB.
简介:联接基长度对非离子与阳离子Gemini表面活性剂间相互作用的影响测定了非离子表面活性剂辛基酚醚(简称PEG—TMBPE)与三种阳离子gemini表面活性剂alkanediyl—a,x—his(dimethvldodecvIammon|umbromide)(12-s-12.S=2、4和6)复配体系的表面张力,并用小角度中子散射法测定了胶束的大小与胶团聚集数。结果表明:1)随着gemini表面活性剂连接基长度的增加以及混合体系中辛基酚醚含量的增加,两种表面活性剂之间的协同作用明显增大;2)混合胶束化是热力学自发进行的,混合胶柬的稳定顺觅序为:PEG—TMBPE+12-2—12〈PEG—TMBPE+12—4—12〈PEG—TMBPE+12—6—12。该混合体系的协同效应源于阳离子gemini表面活性剂亲水头基间的静电斥力的减小,是由以下两个因素引起的:1)辛基酚醚含量增加时使gemini表面活性剂亲水头基之间的空间位阻增大;2)12-s-12q3连接基长度增加,使阳离子gemini表面活性剂的疏水性增大,同时使其亲水头基的极性增大。
简介:在国外工作生活,住是最首当其冲的。有一套好住宅,再遇上相互关心的邻居,多少能冲淡一些乡恋的愁苦。最近,我们到美洲一些国家参观,对国外的住房物业管理情况有些了解。国外的住房分为别墅和公寓两类,一般的别墅指那种独门独院的住宅,房屋设计各式各样,大多有车库、花园,这种住宅居住、办公、会客都很方便,但房屋维修、保安等也是心头之患。如果所住地的社会治安状况不好,那么房屋失窃就有可能发生,也许等你一家人外出度假回来,发现房间已被小偷光顾了。所以,住这种住宅总有提心吊胆的感觉。这种房屋煤、水、电、热设施等在房屋建造之时都按设计安装完毕,有事可拨打电话,各个公司派人维修,房屋的室内装修以及花园的格式,包括类似
简介:Humanglioblastomas(GBM)arethoughttobeinitiatedbygliomastem-likecells(GSLCs).GSLCsalsoparticipateintumorneovascularizationbytransdifferentiatingintovascularendothelialcells.Here,wereportacriticalroleofGSLCsintheformationofvasculogenicmimicry(VM),whichdefineschannelslinedbytumorcellstosupplynutrientstoearlygrowingtumorsandtumor
简介:Glioblastomaisoneofthemostangiogenichumantumorsandcharacterizedbymicrovascularproliferations.Abetterunderstandingofglioblastomavasculatureisneededtooptimizeanti-angiogenictherapythathasshownapromisingbutincompleteefficacy.Thepresentstudyexamined48glioblastomasbyCD34endothelialmarkerperiodicacid-Schiff(PAS)dualstainingandfoundnon-endothelialcell-linedblood
简介:苏联召开作为外语的俄语教学法学术讨论会去年初,莫斯科大学外国学生俄语教育部召开了“俄语课语言教学法问题”学术讨论会。这次会议是在莫斯科大学自然科学各系为外国留学生设立俄语教研室三十周年时召开的。莫斯科、巴库、伏尔加格勒等十一个城市的高等院校的230名代表参加了会议。在全体会议上听取了解决俄语课堂教学中的一些主要倾向性问题的学术报告。莫斯科大学的B.B.多布罗沃利斯卡亚在报告中分析了作为外语教学的俄语实践课的性质和特点,以及在这方面反映出来的教学进度问题和现在研究的水平。她认为现代俄语课的交际性和信息性、教学的互相联系与互相渗