简介：Jimandhismotheraresittingatthetable.Theyarehavinglunch.

简介：MrandMrsYateshadonedaughter.HernamewasCarol,andshewasnineteenyearsold.Carollivedwithherparentsandworkedinanoffice.Shehadsomefriends,butshedidnotlikeanyoftheboysverymuch.

简介：Theintroductionofdesigneroestrogensasatreatmentmedalityinhormonereplacementinwomenhasinvitedtoconsidertheconceptofcompoundswithselectiveandrogeniceffectsformalehonnonereplacementtherapy.Thefullspectrumoftheactionsoftestosteronemaynotbenecessaryofevenundesiredforcertainindicationsfortestosteronetreatment,Todefineforwhatindicationscertainandrogenicpropertiesaredesiredandundesiredmoreinsightinbasicandrogen(patho)physiologyisrequired.Thereisconvincingevidencethataromatizationofandrogeniccompoundstonestrogensmightbeanadvantageformaintenanceofbonemassanditmightalsomitigatenegativeeffectsofandrogensonbichemicalparametersofcardiovascularrisks:thepotentiallynegativeeffectsofoestmgensonprostatepathologyinageingmenneedsfurtherelucidation.Whiletheroleofdihydro-testosterone(DHT)forthemalesexualdifferentiationandforpubertalsexualmaturationisevident,itsroleinmatureandageingmalesseemslesssignificantormayevenbeharmful.Itis,however,ofnotethatanegativeeffectofDHTonprostatepathophysiolog~iscertainlynotproven.Formalecontraceptionaprogestationalagentwithstrongandrogenicpropertiesmightbeanasset.Formostoftheandrogenicactionsthecriticallevelsofandrogensarenotwellestablished.Thelatterisrelevantsincethelargeamountofandrogenmoleculesrequiredforitsbiologicalactions(ascomparedtooestrogens)isanimpedimentinandrogenreplacementmedalities.Theremayberoomformorebiopotentandrogenssincedeliveryoflargeamountsofandrogenmoleculestothecirculationposesproblemsfurtreatmentmodalities.(AsianJAndro11999Jun;1:21-28)

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简介：目的探讨应用S-腺苷-L-蛋白氨酸(SAMe)治疗老年性药物性肝损伤的疗效以及还原型谷胱甘肽对判断疗效的意义。方法应用S-腺苷-L-蛋氨酸(SAMe)对24例因各种药物引起的肝损害给予治疗，连续静脉给药800mg／日，3周，动态观察治疗前后临床表现和各项肝功能指标及GSH水平变化情况。结果治疗后精神、睡眠、食欲好转，乏力减轻，肝功能指标明显下降，GSH水平从治疗前的6．21±0．89mmol／L升至7．40±0．61mmol／L。结论S-腺苷-L-蛋氨酸(SAMe)对治疗老年性药物性肝损害有明显疗效，能明显改善肝功能和抗氧化作用。检测血清GSH水平变化情况对判断肝损害的疗效及预后有重要和直接的意义。