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简介：Objective:Tostudytheexpressionofvascularendothelialgrowthfactor(VEGF)andmicrovesseldensity(MVD)inesophagealsquamouscellcarcinoma(ESCC)andclarifytheassociationofVEGFexpressionwiththeangiogenesisandprognosticvalueofthisdisease.Methods:Eighty-twocaseswithprimaryESCCtreatedwithradicaloperationinDepartmentofSurgeryfromJan1981throughMay1994wereenrolled.VEGFexpressionandMVDvaluewereexaminedbyimmunohistochemicalstaining,thestreptavidin-biotinperoxidasecomplexmethod(SPmethod),usinganti-VEGFpolyclonalantibodyandanti-Factor-VIIIantibody,respectively.WealsoanalyzedtherelationshipbetweenVEGFexpressionandMVDvalueandpostoperativesurvivalrateofpatients.Results:Ofthe82cases,63.4%casesshowedpositiveforVEGFintumorcellsandthemedianofMVDintumorwas37(9-150)·mm-2.TherewasaclosecorrelationbetweenMVDandVEGF(P=0.001).The5-yearsurvivalrateofpatientswithlowandhighMVDwas34.1%and12.2%,respectively.The5-yearsurvivalratewas46.7%inpatientswithVEGF-negativetumorand11.5%inpatientswithVEGF-positivetumor.Thesedifferenceswerestatisticallysignificant(P=0.017andP<0.001,respectively).Conclusion:InESCC,angiogenesisismediatedmainlybyVEGFandVEGFmaybeassociatedwithtumorprogressionandincreasedmalignancyviaangiogenesis.

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简介：ObjectivesTostudywhetherchangeofBNPlevelsreflectthechangeofcardiacfunctionandtoinvestigatetheshort-termprognosticpotentialofBNPandQOLinpatientswithCHF.Methods96consecutivepatientsadmittedwithCHFbetweenSeptember2002andJanuary2003werestudied,uponentrythestudy,BNPlevelsweremeasured,Patientsadministeredthedisease-specificqualityoflifequestionnaireMinnesotalivingwithheartfailurequestionnaire(LiHFe)within1day.BNPlevelsandadministeringLiHFewererepeatedthreemonthslater.ResultsBNPlevelswereincreasedproportionaltotheseverityofcardiacfunction.PhysicaldomainandtotalscoreofLiHFeweresignificantlycorrelatedtotheseverityofCHF(p＜0.05).BNPlevelsweredecreasedinimprovinggroup(p=0.032).IndeterioratinggroupBNPlevelsincreased(P=0.043).Kaplan-meieranalysisaccordingtoBNPlevelcutoffpoint150ng/l,thelifecurveofhigherBNPlevelgroupwassignificantlylowerthanthelowergroup(p=0.001).Inunivariatelogisticregression,NYHAclass,BNP,LVEF,LVEDD,heartsize,totalscoreofLiHFe,physicaldomainofLiHFeandtheemotionaldomainofLiHFewereallsignificantprognosticfactorsofCHF(p＜0.05forall).Whileinmultipleregression,onlyBNPlevel(p=0.036)andtheemotionaldomainofLiHFe(p=0.025)wereindependentprognosticfactors.ConclusionsChangeofBNPreflectsthetreatmentefficacyofCHF.BNPandQOLarethetwomajorshort-timeprognosticfactorsofthechronicheartfailurepatients.

简介：Objective:Toexplorethecausesoftheformationoftraumaticcarotid-cavernousfistulasandthetherapeuticeffectofdetachableballoonand/orcoilembolizationandthepreventionofitscomplications.Methods:FromOctober,1992toMarch,2002,17patientswithtraumaticcarotid-cavernousfistulasweretreatedwithdetachableballoonand/orcoilembolizationinourhospital.TheclinicaldataandimagingfeaturesofCT,MRandselectiveangiogramofthesepatientswereanalyzed.Results:Oneweekaftertreatmentwithembolization,theclinicalsymptomsofthe17patientswereremitted,andopticcacophony,nystagmus,exophthalmosanddropsyofconjunctivadisappeared.Twopatientsmanifestedsurgicalcomplications,onepatientdied.Sixteenpatientssurvived.Theywereallfollowedupformorethan2years,whichshowedonepatienthadhandicapinmovement,andinonepatientthesignsandsymptomsoftraumaticcarotid-cavernousfistulasreoccurred2monthsaftertreatment.Conclusions:Thedetachableballoonand/orcoilembolizationissafeandreliable.Itisagoodmethodtotreattraumaticcarotid-cavernousfistulas.

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简介：客观：与非小的肺癌症(NSCLC)在病人的预后上在MRP基因overexpression的效果上学习。方法：从NSCLC的47个盒子的嵌入石蜡的纸巾经历了激进的肿瘤切除术的人，用探针与immunohistochemistry相结合的标记的digoxigenin为MRP基因mRNAbyinsitu杂交的表示被检查。所有病人是回顾地跟随起来的。结果：47个肺癌症标本的AU被发现有MRP基因mRNA的overexpression。它显著地在外科以后与病人鈥?幸存时间，对化疗的反应，复发或转移被相关，但是没与组织学，肿瘤尺寸，节点地位，TNM阶段，区别的度，年龄和性别被相关。结论：MRP基因的Overexpression是在有NSCLC的病人的预示的意义的一个标记。