简介：收集神经活动数据从醒着，自由地表现动物，我们由现代芯片开发使小型化的可植入的记录系统:薄片(PSoC)上并且通过在外皮的长期的电极的可编程的系统。与PSoC家庭成员CY8C29466，运作的完成的系统和仪器放大器，过滤器，定时器，广告变流器，和连续通讯，等等。信号处理被处理虚拟仪器技术。这些，因素显著地装的所有影响价格和工程的发展周期。结果证明系统能记录并且分析神经原连续地产生一个星期或更多的神经extrocellular分泌物。这为神经科学和信息工程technique.The电路的学科交差的研究是很有用的，设备的建筑学能带着另外的小动物为神经生物学和研究被改编。

简介：Thestressanalysisofthehumanfemurisconsiderablycomplicated.Inadditiontothemotionalpostureandtheloadingconditionofthefemur,itisgreatlyrelatedtoitsgeometryandbonystructureindifferentparts.Inpreviousresearches,themeansoffemoralshapeusinginthefinite-element-analysiswasobtainedbymeansofapply-ingtheradiographswhichweretheninputincomputer.Obviously,theresultswereneitherrealnorprecise.Inthispaper,thecomputerimageprocessingwasusedtogetthegeometryandthesizeofthehumanfemur,whichcouldmakethefinite-ele-

简介：Mostadultswithauditoryprocessingdisorder(APD)oftenhavetroubleatwork.ItispossiblethattheselisteningproblemsinadultswithAPDinfluencetheirmentalhealth.Thus,wehavetotakethesubject'spersonalityandmentalstatusintoconsiderationwhensupportingsubjectswithAPD.However,studiesonAPDinadultsarecomparativelyrare.Inthisstudy,weaimedtoevaluatetherelationshipsbetweentheresultsofauditorytests,APDsymptoms,andpsychologicalstatusinsubjectswithAPD.Thisstudyincluded22adultswhocomplainedoflisteningproblemsineverydaylife,andtheyunderwentauditoryprocessingtestsandwerequestionedregardingtheirpsychologicalcharacteristics.Fromtheresultsoftheauditoryprocessingtests,allsubjectsshowedlowscoresonatleastonetest;therefore,theyweresuspectedofhavingAPD.Especially,thescoreswerelowontheauditorymemorytest.Furthermore,subjectswithAPDshowrelativelysimilarpsychologicalcharacteristicstoeachother.However,therewasnosignificantrelationshipbetweentheresultsoftheauditoryprocessingtestsandpsychologicalcharacteristics.Wehavetotakenoticeofasubject'spsychologicalstatewhentheyperceivetheirlisteningdifficultiesasalarge-scaleproblemandfeelanxiousasaresult.Forthispurpose,weshouldtakepsychologicalcharacteristicsintoconsiderationatthetimeofthemedicalexaminationinterviewbeforeaudio-psychologicaltesting.

简介：Previousresearchhasdemonstratedthattheamplitudeofevokedemissionsdecreasesinhumansub-jectswhenthecontralateralearisstimulatedbynoise.Themedialolivocochlearbundle(MOCB)isbe-lievedtocontrolthisphenomenon.Recentresearchhasexaminedthiseffectinindividualswithauditorypro-cessingdisorders(APD),specificallywithdifficultyunderstandingspeechinnoise.Resultsshowedtran-sientevokedotoacousticemissions(TEOAEs)werenotaffectedbycontralateralstimulationinthesesub-jects.MuchclinicalresearchhasmeasuredthefunctionoftheMOCBthroughTEOAEs.Thisstudywilluseanalternativetechnique,distortionproductotoacousticemissions(DPOAEs),toexaminethisphenomenonandevaluatethefunctionoftheMOCB.DPOAEsofindividualsinacontrolgroupwithnormalhearingandnosignificantauditoryprocessingdifficultieswerecomparedtotheDPOAEsofchildrenwithsignifi-cantauditoryprocessingdifficulties.Resultsshowedthatthesuppressioneffectwasobservedinthecontrolgroupat2kHzwith3kHzofnarrowbandnoise.Fortheauditoryprocessingdisordersgroup,nosignificantsuppressionwasobserved.Overall,DPOAEsshowedsuppressionwithcontralateralnoise,whiletheAPDgrouplevelsincreasedoverall.TheseresultsprovidefurtherevidencethattheMOCBmayhavereducedfunctioninchildrenwithAPD.

简介：Aim:TocomparetherecoveryrateofmorphologicallynormalandchromatincondensedspermatozoafromnativesemensamplesusingtheSpermPrepTMfiltrationcolumnsandPercollgradientcentrifugationandtodeterminetheinfluenceofthetwoprocessingtechniquesonfertilizationandpregnancyratesinanIVF-ETprogram.Methods:Sixteensemensamplesobtainedfrompatient'shusbandwereincludedinthisstudy.Eachwasdividedintotwoaliquots.ThefirstaliquotwasprocessedwithSpermPrepTMfiltrationcolumnsandthesecond,Percollgradientcentrifugation.Smearsweremadebeforeandaftersemenprocessingwithbothmethodsfortheevaluationofchromatincondensation(chromomycineCMA3)aswellasmorphology(strictcriteria)ofspermatozoa.Onehundredandseventyoocyteswereretrievedfromthepatientsandtheoocytesfromeachpatientweresubdividedintotwosets:onesetwasinseminatedusingspermatozoaprocessedwithSpermPrepTMandtheotherinseminatedaftersemenprocessingwithPercollgradientcentrifugation.Resuits:ThePercollmethodyieldedasignificantlyhigherpercentageofchromatincondensed(90.8±6.5%vs82.3±8.8%,P=0.017)andmorphologicallynormalspermatozoa(12.9±7.4%vs6.9±4.8%,P=0.001)incomparisontoSpermPrepTM.Whereas,spermcountrecoveryratewassignificantlyhigheraftertheuseofSpermPrepTMthanafterthePercollgradientcentrifugation.Thefertilizationratewassimilarbetweenthetwomethods.Conclusion:SemenprocessingwithPercollshouldberecommendedforintracytoplasmicsperminjectionasthenaturalselectionisbypassedandtheSpermPrepTMtechniquecouldberecommendedfor1VFandIUIprogramsasthespermconcentrationplaysamoresignificantroleintheseprocedures.

简介：AbstractPurpose:To retrospectively analyze the clinical outcomes of meniscus repair with simultaneous anterior cruciate ligament (ACL) reconstruction and explore the causes of failure of meniscus repair.Methods:From May 2013 to July 2018, the clinical data of 165 patients who were treated with meniscus surgery and simultaneous ACL reconstruction, including 69 cases of meniscus repair (repair group) and 96 cases of partial meniscectomy (partial meniscectomy group) were retrospectively analyzed. The exclusion criteria were as follows: (1) ACL rupture associated with fracture, collateral ligament injury, or complex ligament injury; (2) a history of knee surgery; or (3) a significant degree of osteoarthritis. The 69 patients in the repair group were divided into the non-failure group (62 cases) and the failure group (7 cases) depending on the repair effect. Postoperative outcomes of the repair group and the partial meniscectomy group were compared. General conditions and postoperative outcomes of the failure group and the non-failure group were compared. During the median follow-up period of 28 months (range, 4 - 65 months) after the second arthroscopy, postoperative outcomes of seven patients in the failure group were summarized. SPSS 25.0 statistical software was used for statistical analysis. A p value less than 0.05 was considered statistically significant.Results:Seven patients in the failure group who underwent the second arthroscopy were followed up for (30 ± 17.4) months and their postoperative outcomes were summarized. Compared with the partial meniscectomy group, the International Knee Documentation Committee scores of patients in the repair group improved significantly (p = 0.031). Compared with the non-failure group, more patients in the failure group were younger than 24 years (p = 0.030). The median follow-up period was 39.5 months. All patients recovered well after subsequent partial meniscectomy and relieved clinical symptoms. Visual analog scale scores decreased significantly (p = 0.026), and the International Knee Documentation Committee and Lysholm scores improved significantly (p = 0.046 for both).Conclusion:The failure rate of meniscus repair in this study was 10.1% (7/69), all of which were medial meniscus tears. However, the surgical outcomes of ACL reconstruction were not affected, and there might be a role for graft protection. Therefore, meniscus retears can be successful treated by performing subsequent partial meniscectomy in patients with repair failure.

简介：Objective:TodemonstratetheperformancebenefitoftheAutomaticSceneClassifier（SCAN）algorithmavailableintheNucleus6（CP900series）soundprocessoroverthedefaultprocessingalgorithmsofthepreviousgenerationNucleus5（CP810）andFreedomHybridTMsoundprocessors.Methods:Eighty-twocochlearimplantrecipients（40Nucleus5processorusersand42FreedomHybridprocessorusers）listenedtoandrepeatedAzBiosentencesinnoisewiththeircurrentprocessorandwiththeNucleus6processor.Results:TheSCANalgorithmwhenenabledyieldedstatisticallysignificantnon-inferiorandsuperiorperformancewhencomparedtotheNucleus5andFreedomHybridsoundprocessorsprogrammedwithASCtADRO.Conclusion:TheresultsofthesestudiesdemonstratethesuperiorperformanceandclinicalutilityoftheSCANalgorithmintheNucleus6processorovertheNucleus5andFreedomHybridprocessors.

简介：Havingawiderangeofmotion,thecervicalspineisratherpredisposedtotrau-maandotherdisorderswithseriousconsequences.Themotionofcervicalspineisacomplexonecomposedofmicromotions,includinghorizontaldisplacementsalongallthreeaxesandrotationsaroundthemwithsixfreedomdegreesofmovement.Reportonprecisemeasurementofthethree-dimensionalmotionofthecervicalsectionof

简介：AbstractMany factors have been identified as having the ability to affect the sensitivity of rapid antigen detection (RAD) tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to identify the impact of sample processing on the sensitivity of the RAD tests. We explored the effect of different inactivation methods, viral transport media (VTM) solutions, and sample preservation on the sensitivity of four RAD kits based on two SARS-CoV-2 strains. Compared with non-inactivation, heat inactivation significantly impacted the sensitivity of most RAD kits; however, β-propiolactone inactivation only had a minor effect. Some of the VTM solutions (VTM2, MANTACC) had a significant influence on the sensitivity of the RAD kits, especially for low viral-loads samples. The detection value of RAD kits was slightly decreased, while most of them were still in the detection range with the extension of preservation time and the increase of freeze-thaw cycles. Our results showed that selecting the appropriate inactivation methods and VTM solutions is necessary during reagent development, performance evaluation, and clinical application.

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简介：AconitiLateralisRadixPraeparata(Fuzi)isacommonlyusedtraditionalChinesemedicineinclinicforitspotencyinrestoringyangandrescuingfromcollapse.Aconitialkaloids,mainlyincludingmonoester-diterpenoidaconitines(MDAs)anddiester-diterpenoidaconitines(DDAs),areconsideredtoactasbothbioactiveandtoxicconstituents.Inthepresentstudy,afeasible,economical,andaccurateHPLCmethodforsimultaneousdeterminationofsixalkaloidmarkersusingtheSingleStandardforDeterminationofMulti-Components(SSDMC)methodwasdevelopedandfullyvalidated.Benzoylmesaconinewasusedastheuniquereferencestandard.Thismethodwasprovenasaccurate(recoveryvaryingbetween97.5%-101.8%,RSD<3%),precise(RSD0.63%-2.05%),andlinear(R>0.9999)overtheconcentrationranges,andsubsequentlyappliedtoquantitativeevaluationof62batchesofsamples,amongwhich45batcheswerefromgoodmanufacturingpractice(GMP)facilitiesand17batchesfromthedrugmarket.Thecontentswerethenanalyzedbyprincipalcomponentanalysis(PCA)andhomogeneitytest.ThepresentstudyprovidedvaluableinformationforimprovingthequalitystandardofAconitiLateralisRadixPraeparata.ThedevelopedmethodalsohasthepotentialinanalysisofotherAconitumspecies,suchasAconitumcarmichaelii(preparedparentroot)andAconitumkusnezoffii(preparedroot).

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