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简介：假设那床材料负担等于沉积运输能力通常是可接受的，如果在床和流动之间的交换即刻地发生。为非平衡沉积运输过程，然而，有空间、时间的延期效果。这为水库沉积过程是特别真的。恢复因素是为非平衡沉积运输的一个系数。恢复因素的决心能试验性地或数字地被获得。在以前的文学的恢复因素的价值上没有一致。有半的数字模拟--二个维的沉积运输模型，GSTARS4，为以前的研究建议的恢复因素的决心用各种各样的方法在这研究被进行。一座水库的模仿的结果几何变化对恢复因素的选择敏感。恢复因素作为沉积尺寸的功能提供了最合理的结果，这被发现。在恢复因素和沉积尺寸之间的一种功能的关系被比较模仿并且测量的水库决定几何变化。粗糙的沉积有恢复因素的小价值。

简介：Transforminggrowthfactor-β(TGF-β)isakeyfactorincancerdevelopmentandprogression.TGF-βcansuppresstumorigenesisbyinhibitingcellcycleprogressionandstimulatingapoptosisinearlystagesofcancerprogression.However,TGF-βcanmodulatecancer-relatedprocesses,suchascellinvasion,distantmetastasis,andmicroenvironmentmodificationthatmaybeusedbycancercellstotheiradvantageinlatestages.Correspondingmechanismsincludeangiogenesispromotion,anti-tumorimmunitysuppression,andepithelial-to-mesenchymaltransition(EMT)induction.ThecorrelationbetweenTGF-βexpressionandcancerprognosishasalsobeenextensivelyinvestigated.ResultssuggestthatTGF-βpathwaycanbetargetedtotreatcancer;assuch,thefeasibilityofthistreatmentisinvestigatedinclinicaltrials.

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简介：Inordertofindthedominantfactorofenergyefficiencychange,thispaperusesthemodifiedstructuralmodeltoanalyzeenergyefficiencychangefrom1990to2012inXinjiang.Theresultshowsthattheenergyefficiencyincreaseislargelyduetoenergytechnologicalinnovationespeciallybytheindustrialsector,andthecontributionfromstructuralshiftislimited.Therefore,weshouldvigorouslysupportenergy-savingtechnologicalprogressintheindustrialsectoranddevelopthemodernserviceindustrieswithlowerenergyconsumption,inordertorealizethegoalofimprovingenergyefficiency.

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简介：Theliteratureshowsthatimprovementsincognitiveperformancemaybeobservedfollowinganacuteboutofexercise.However,evidenceinsupportofthebiologicalmechanismsofthiseffectisstilllimited.Findingsfrombothrodentandhumanstudiessuggestbrain-derivedneurotrophicfactor(BDNF)asapotentialmechanismoftheeffectofacuteexerciseonmemory.ThemolecularpropertiesofBDNFallowthisproteintobeassessedintheperiphery(pBDNF)(i.e.,bloodserum,bloodplasma),makingmeasurementsofacuteexercise-inducedchangesinBDNFconcentrationrelativelyaccessible.StudiesexploringtheacuteexerciseepBDNFecognitiveperformancerelationshiphavehadmixedfindings,butthismaybemorereflectiveofmethodologicaldifferencesbetweenstudiesthanitisastatementabouttheroleofBDNF.Forexample,significantassociationshavebeenobservedbetweenacuteexercise-inducedchangesinpBDNFconcentrationandcognitiveperformanceinstudiesassessingmemory,andnon-significantassociationshavebeenfoundinstudiesassessingnon-memorycognitivedomains.ThreesuggestionsaremadeforfutureresearchaimedatunderstandingtheroleofBDNFasabiologicalmechanismofthisrelationship:1)Assessmentsofcognitiveperformancemaybenefitfromafocusonvarioustypesofmemory(e.g.,relational,spatial,long-term);2)MorefinegrainedmeasurementsofpBDNFwillallowfortheassessmentofconcentrationsofspecificisoformsoftheBDNFprotein(i.e.,immature,mature);3)StatisticaltechniquesdesignedtotestthemediatingroleofpBDNFintheacuteexercise-cognitiveperformancerelationshipshouldbeutilizedinordertomakecausalinferences.

简介：AIMToinvestigatetherolesandinteractionsofmutThomolog（MTH）-1andhypoxia-induciblefactor（HIF）-1αinhumancolorectalcancer（CRC）.METHODS：TheexpressionanddistributionofHIF-1αandMTH-1proteinsweredetectedinhumanCRCtissuesbyimmunohistochemistryandquantitativerealtimepolymerasechainreaction（qRT-PCR）.SW480andHT-29cellswereexposedtonormoxiaorhypoxia.ProteinandmRNAlevelsofHIF-1αandMTH-1wereanalyzedbywesternblottingandqRT-PCR,respectively.InordertodeterminetheeffectofHIF-1αontheexpressionofMTH-1andtheamountof8-oxodeoxyguanosinetriphosphate（dGTP）inSW480andHT-29cells,HIF-1αwassilencedwithsmallinterferingRNA（siRNA）.GrowthstudieswereconductedoncellswithHIF-1αinhibitionusingaxenografttumormodel.Finally,MTH-1proteinwasdetectedbywesternblottinginvivo.RESULTS：HighMTH-1mRNAexpressionwasdetectedin64.2%ofcases（54/84）,andthiswassignificantlycorrelatedwithtumorstage（P=0.023）andsize（P=0.043）.HIF-1αproteinexpressionwascorrelatedsignificantlywithMTH-1expression（R=0.640;P〈0.01）inhumanCRCtissues.HypoxicstressinducedmRNAandproteinexpressionofMTH-1inSW480andHT-29cells.InhibitionofHIF-1αbysiRNAdecreasedtheexpressionofMTH-1andledtotheaccumulationof8-oxo-dGTPinSW480andHT-29cells.Intheinvivoxenografttumormodel,expressionofMTH-1wasdecreasedintheHIF-1αsiRNAgroup,andthetumorvolumewasmuchsmallerthanthatinthemocksiRNAgroup.CONCLUSION：MTH-1expressioninCRCcellswasupregulatedviaHIF-1αinresponsetohypoxicstress,emphasizingthecrucialroleofHIF-1α-inducedMTH-1intumorgrowth.

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简介：我们识别了米饭花的机关发展异种，称为的同样开的壳和男性无菌1(ohms1)，从indicarestorer线的子孙，Zhonghui8015与60Co光线照耀对待。ohms1异种展出了开的壳并且像词根并且象palea一样组织在花药和耻辱之间的变换，它导致了显示出‘tridentatelemma’的ohms1异种小穗状花小穗。ohms1异种是完全无菌却有的60%-70%肥沃的花粉。印射的基因分析和基因证明ohms1被单个后退的基因控制，并且变异的基因对在标记KY2和KY29之间的染色体3的短手臂上的42-kb间隔印射罚款。在这个区域的四个开的读物框架的顺序分析表明异种在第五intron的最后底带了单个核苷酸转变(到G的A)，它多半被通信到ohms1phynotype，在一种MIKC类型疯盒子的基因OsMADS1(LOC_Os03g11614)。进一步定序的酶消化和cDNA显示可变拼接在MADS领域或氨基酸框架为在ohms1，而是没有结构的变化的第六exon的删除负责移动出现了。另外，即时荧光灯量的PCR分析证明OsMADS1表示水平在ohms1异种显著地减少了。发展相关的基因也显著地改变了的米饭flowering因素和花的颖的表示层次。这些结果证明OsMADS1可以在米饭起一个重要作用花的机关开发，特别地在花的颖开发和小花原基区别。

简介：这研究分析社区结构，水藻的数量变化和重要环境因素的效果并且在调查区域估计依附的绿水藻的全部的生物资源。从Porphyrayezoensis水产业椽子上的依附的绿水藻的调查的学习使用数据和关于到在Subei的2011年4月的从2010年10月的环境因素的数据变浅。椽子上的依附的绿水藻包括了Ulvaprolifera，Capsosiphongroenlandicus，U。linza，U。intestinalis，U。clathrata，和U。compressa。依附的绿水藻的生物资源变化展出了一根转换抛物线：生物资源最高(14898t)在4月，并且第二最高(2034t)在11月；它在2月(仅仅729t)是最低的并且从三月严厉地增加了到4月。种类差异在季节之中显著地不同。在9月和10月，什么时候P。yezoensis水产业椽子开始被建立，，依附的绿水藻从12月有高生物多样性到下一2月，，许多绿水藻种类在椽子上共存了生物资源是低的，并且从三月到4月作为严厉地增加的生物资源，种类差异落下到最小。在期间这次，C。groenlandicus与直到80%的最大的生物资源比例是显然主导的，当时U。prolifera比例指数地增加了到20%～40%。水温度在生物资源和依附的绿水藻的种类继任上有直接调整效果。社区动力学的评价和绿水藻的生物资源提供了需要在南部的黄海追踪大规模绿潮的起源的证据。

简介：Olderadultsoftenfinditdifficulttoperceivespeech,especiallyinnoisyconditions.Thoughhearingaidisoneoftherehabilitativedevicesavailabletoolderadultstoalleviatehearingloss,someofthemmayexperienceannoyancethroughhearingaidandhencerejectit.maybeduetocircuitrynoiseand/orbackgroundnoise.Acceptablenoiselevelisadirectbehaviouralmeasuretoestimatetheextentofhowmuchapersonisabletoputupwithnoisewhilesimultaneouslylisteningtospeech.Acceptablenoiselevelisacentralauditorymeasureanditisnotinfluencedbyage.gender,presentationlevelorspeaker.Usingthismeasure,wecanquantifytheannoyancelevelexperiencedbyanindividual.Thisinformationisofutmostimportanceandcautionshouldbepaidbeforesettingtheparametersinhearingaid,especiallyforthosewhoareunabletoacceptnoise.Inthisreviewarticle,anattempthasbeenmadetodocumenthowtooptimizethehearingaidprogrambysettingparameterssuchasnoisereductioncircuit,microphonesensitivityandgain.Theseadjustmentsofparametersmighthelptoreducerejectionrateofhearingaids,especiallyinthoseindividualswhoareannoyedbybackgroundnoise.

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简介：Parkinson’sdisease(PD)ischaracterizedbytheprogressivelossofmidbraindopaminergic(mDA)neuronsandasubsequentdecreaseinstriataldopaminelevels,whichcausethetypicalclinicalmotorsymptomssuchasmusclerigidity,bradykinesiaandtremor.Althoughasubsetof