简介：AbstractInfertility seriously endangers the reproductive health of women at childbearing age. It is defined as the failure to achieve successful pregnancy after 1 year or more of regular unprotected intercourse. Broadly defined, infertility includes two aspects - failure to conceive or have a live birth. This guideline only addressed content relevant to the former. It was proposed by the gynecological endocrine group of the Chinese Society of Obstetrics and Gynecology, Chinese Medical Association, based on relevant guidelines of the World Health Organization, the American Society for Reproductive Medicine, the National Institute for Health and Clinical Excellence, as well as the clinical practice in China. The guideline was reviewed by experts and doctors from medical institutions at all levels, which is applicable to the diagnosis of infertility by physicians in obstetrics, gynecology, and andrology at various medical institutions nationwide.

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简介：HL-2Atokamakisthefirstnon-circularcross-sectiontokamakwithdivertorinChina.ApartfromboundarytransportandSOLstudy,theHL-2AmajorsubjectistoinvestigatetheimprovementofconfinementwithhighparametersandalotoffrontphysicsandrelevantengineeringtechniquesbyuseofitsspecialCloseddivertorwithlargevolumeinChina.

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简介：AbstractAlthough whole-exome sequencing and whole-genome sequencing has tremendously improved our understanding of the genetic etiology of human disorders, about half of the patients still do not receive a molecular diagnosis. The high fraction of variants with uncertain significance and the challenges of interpretation of noncoding variants have urged scientists to implement RNA sequencing (RNA-seq) in the diagnostic approach as a high throughput assay to complement genomic data with functional evidence. RNA-seq data can be used to identify aberrantly spliced genes, detect allele-specific expression, and identify gene expression outliers. Amongst eight studies utilizing RNA-seq, a mean diagnostic uplift of 15% has been reported. Here, we provide an overview of how RNA-seq has been implemented to aid in identifying the causal variants of Mendelian disorders.

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简介：为非线性的系统的诊断计划基于neurofuzzy联网的一个联机差错在这篇论文被建议。计划包含二个阶段。在第一个阶段，非线性的系统被一个neurofuzzy网络接近，它从在系统的正常操作期间获得的数据脱机被训练。在第二个阶段，剩余从这个网络在网上被产生并且被在网上训练的另一个neurofuzzy网络建模。模糊规则从这个网络被提取，并且与在在不同有缺点的操作，差错从被诊断下面获得的差错数据库的那些相比。建议聪明的差错计划的性能在不同有缺点的条件下面用一个二坦克的水水平控制系统被说明。

简介：AbstractCoronavirus disease 2019 (COVID-19) is a newly emerged infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The number of COVID-19 cases is continuously increasing and no effective drugs or vaccines are currently available. Accurate and efficient diagnostic testing methods are desperately needed for the detection of SARS-CoV-2 and antiviral antibodies in infected individuals. Various assay techniques, including nucleic acid tests [eg, polymerase chain reaction (PCR), reverse transcription-PCR, real-time loop-mediated isothermal amplification, and CRISPR-Cas-based detection], serological tests [eg, immunoglobulin (Ig)A, IgM/G], imaging tests (eg, computed tomography and positron-emission tomography), and nanoparticle-based detections have been reported for COVID-19 diagnosis. This review aims to present the current diagnostic tools for SARS-CoV-2 and their performance characteristics to inform the appropriate selection of diagnostic and surveillance technologies at optimal testing times. We also describe the advantages of detection using combined nucleic acid and imaging tests, or serological testing and point-of-care diagnostics. Developing reliable protein biomarkers targeting the conserved proteins of SARS-CoV-2 rather than IgA, IgM, or IgG would be useful to manage SARS-CoV-2.

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简介：TheconcernoveroutliersisoldsinceBernoulli(see[12]),reviewedhistoricallyby[11]andupdatedwith[10]intheirencyclopediatextbook.Jamesetal.[46]usedsimulationtechniquetocomparesomerecentpublishedoutlierdetectionprocedures.Thehistoryofadeptanddiagnosisofoutliersistracedfromoldandpresencecomments.Theil-typeorRank,Brown-Mood,Lp,M,adaptiveM,GM,andTrimmed-Winsorizationestimatorsarethemostpopularestimatorsthatwewillreviewinthispaperasanapplicationtooutlieraccommodation.Wewillreviewandcomparethemostnumericalandgraphicaldisplaysbasedonresidualstoflagoutliers.

简介：AnumericalsimulationofatorrentialraineventoccurringintheJiang-HuaiValleyofChinafrom22-24June1999isperformedandanalyzedbyusingthePSU/NCARMM5mesoscalenon-hydrostaticmodel.Thehigh-resolutionmodeloutputdataareutilizedtodiagnosethedoublefrontstructure,andthedistributionsofpotentialtemperature,equivalentpotentialtemperature,andspecifichumidityinthevicinityoftheMeiyuFrontSystem(MYFS)intheJiang-HuaiValley.TheresultsshowthatboththepotentialtemperaturegradientandthespecifichumiditygradienthaveimportantimpactsonthetwostrongequivalentpotentialtemperaturegradientzonesassociatedwiththedoublefrontstructureoftheMYFS,butthelatter(moisturegradient)ismoreimportant.Inaddition,thetendencyequationofspecifichumiditygradientistheoreticallyderived.Itshowsthatvariationsofthespecifichumiditygradientarerelatedtotheadvection,convergence/divergence,horizontalandverticalvorticities(secondarycirculation)effectsandthegradientofwatervaporsource/sink.Asanexample,thebudgetofthemeridionalcomponentofthetendencyequationisselectedanddiagnosedbyusingtheabovemodelsimulationdataofthetorrentialrainevent.Itisshownthatthevariationofthespecifichumiditygradientaveragedthroughoutthesimulationismainlycontrolledbytheconvergence/divergenceeffect,thesecondarycirculationeffectassociatedwiththehorizontalvorticities,andthewatervaporsource/sinkeffect.Sincethewatervaporsource/sinkisoftenformedfromthephasechangeprocessesofwatervaporintheairandthusdirectlyassociatedwithcloudandprecipitationmicrophysicsprocesses,thevariationofthespecifichumiditygradientiscloselyrelatedwithcloudandprecipitationmicrophysicsandthedistribution,developmentandevolutionofcloudandrainfallsystems.ThedoublefrontstructureoftheMYFSprovidesanadvantageousenvironmentalconditionforthedevelopmentandmovementofthemesoscaletorrentialrain

简介：材料，体积或平面波导的有弹性、震动的性质，被Brillouin和拉曼光谱学学习在眼镜陶艺跟随nanocrystals生长的过程。nanoparticles原因外观在低频率拉曼光谱，典型山峰，谁的放，取决于晶体的尺寸。同时，由于光声子，锋利的水晶山峰出现在拉曼系列，允许起核心作用的阶段，和Brillouin山峰的频率移动的决心被观察。CLC数字TB383现在的工作与MIUR-FIRBRBNE012N3X的金融支持部分被资助了，MIURPRIN，轻拍FAPVU2004鈥?006。

简介：在过去几年，乍见陆地并且轨道，紧张，支撑热带气旋的机制(此后TC)并且联系天气变化变得加热了研究的话题。从精力转变，潮湿转移，中间纬度的baroclinicfrontal地区和周围的风领域的观点，陈等。Le等。并且Zengetal。学习了乍见陆地做了的TC的支撑的机制。李等。另外指出TCsduring转变的增强与骚乱并且向下被联系在TC附近的high-levelpotential旋涡，低级锋带和低压的循环的交通，在解释以后，在TC的差别转移跟随湿潜在的旋涡的理论。

简介：AbstractFat embolism syndrome (FES) is a serious life-threatening manifestation of the fat embolism phenomenon characterized by Bergman’s triad of dyspnea, petechiae and mental confusion. While fat embolization into systemic circulation is common, FES occurs in a meagre 0.05%-3% of patients having isolated long bone fractures. Though visual symptoms are commonly attributed to fat embolism retinopathy and is a later occurrence, it may not always be the case. Cortical blindness has been seldom reported in association with FES, and less so as a presenting complaint. Furthermore, no previous literature has described the same in context of an isolated tibia fracture. We report a 20-year-old gentleman with an isolated right tibia shaft fracture who developed sudden onset diminution of vision in both eyes less than 24 h following trauma with no other complaints. Lack of any remarkable ophthalmoscopic findings or other symptoms left us with a diagnostic conundrum. He later went on to develop altered mentation, hypoxia and generalized tonic-clonic seizures with subsequent MRI revealing multiple cerebral fat emboli also involving both occipital lobes. Supportive measures were instituted and his general condition as well as vision gradually improved following which he underwent plate fixation of the fracture under spinal anaesthesia. The perioperative period was uneventful and he was discharged following staple removal. At one month of follow-up, the patient had no residual visual field defects or neurological deficits. Though FES is rare among isolated tibia fractures, this clinical catastrophe may strike in any unsuspected setting thereby warranting a high index of suspicion to ensure early diagnosis and improved patient outcomes.