简介：为前列腺癌症介绍雄激素剥夺治疗的最适当的时间仍然保持争论。我们的目的是在在老鼠前列腺(流浪者)的转基因的腺癌的癌症前进和幸存建模的前列腺上评估早对推迟的外科的阉割的效果。流浪者老鼠随机被划分成三个组：早阉割组(在哪个上阉割在4个星期岁时被执行)，推迟的阉割组(在哪个上当腹的瘤能被摸时，阉割被执行)，并且假冒阉割组。老鼠每天在整个他们的生活被监视直到癌症相关的死亡或显然垂死的外观，在时间，单个老鼠被打死的发展。在前列腺瘤的雄激素受体表达式也被计算。在早阉割，推迟的阉割和假冒阉割的平均lifespan组织的结果表演分别地是54.1个星期，59.9个星期和39.1个星期。当时，早阉割和推迟的阉割授与一个统计上重要的幸存优点与假冒阉割组相比(P<0.001)。然而，在在早阉割组和推迟的阉割组之间的lifespan的差别不是统计上重要的(P=0.85)。在收到了早或推迟的阉割的TRAMP老鼠的lifespan的增加比假冒阉割老鼠在死亡与更低的G/B价值(泌尿生殖器的道重量/身体重量)相关。在结论，在流浪者老鼠的早、推迟的阉割延长了幸存到类似的程度。这发现可以在前列腺癌症治疗为临床的实践提供一个指南。

简介：AbstractPurpose:It is a challenge for the primary hospitals to manage multiple trauma patients. In this article, we explored the advantage of establishing a surgical intensive care unit (SICU) predominant by cardiothoracic surgeons in the early management of multiple trauma.Methods:This was a retrospective study and patients with multiple trauma in our hospital were collected and divided into two groups, based on time period and treat modes: group A (retrospective observation group) where patients were treated with the traditional treatment mode from January 2017 to December 2017 and group B (study group) where patients were treated in the SICU predominant by cardiothoracic surgeons from January 2018 to December 2018. Clinical data including demographics, injury severity score (ISS), causes of injury, time intervals from reception to entering SICU or operating room and mortality three days after injuries were collected. Data were analyzed by SPSS 20.0 software. Categorical variables were presented as number and/or frequency and continuous variables as mean ± SD.Results:Altogether 406 patients were included in this study, including 217 patients in group A and 189 patients in group B. General data between the two groups revealed no significant difference: mean age (years) (35.51 ± 12.97 vs. 33.62 ± 13.61, p = 0.631), gender distribution (mean/female, 130/87 vs. 116/73, p = 0.589) and ISS (15.92 ± 7.95 vs. 16.16 ± 6.89, p = 0.698). Fall from height were the dominant mechanism of injury, with 135 cases in group A (71.4%) and 121 cases in group B (55.8%), followed by traffic accidents. Injury mechanism showed no significant differences between two groups (p = 1.256). Introduction of the SICU significantly improved the care of trauma patients, regarding speed and mortality. Time intervals between reception and entering SICU or operating room was (108.23 ± 6.72) min and (45.67 ± 7.96) min in group A and B, respectively (p = 0.001). Mortality three days after injuries was 13.89% and 5.53% in group A and B, respectively (p = 0.005).Conclusion:Establishing a SICU predominant by cardiothoracic surgeons can reduce the early mortality rates in multiple trauma patients.