简介：说比尔盖茨是天才，没有多少人会反对，他拥有多项世界第一他是第一个靠观念、智慧、思维致富，荣登世界首富的人，也是有史以来最年轻的世界首富；他是第一个白手起家、在短短20多年内创造个人财产达到无人能及的商业奇才；他首开新经济致富的先河，成为人类历史上第一个靠软件拥有亿万资产的先知先觉者；他是第一个利用高科技和高智商创造巨额财富的典范……而且他还在继续创造着无数个世界第一。比尔盖茨不但是成功者，而且是所有成功者之神。

简介：Thecombinationofradiotherapy(RT)andfunction-preservingsurgeryisthemostusualcontemporaryapproachinthemanagementofsofttissuesarcomas(STS).Pre-andpostoperativeRTresultinsimilarlocalcontrolrates,asshownbyalandmarktrialinextremitySTS.Inthisreview,theroleofRTinthemanagementofextremitySTSwillbediscussed,butSTSinothersites,includingretroperitonealSTS,willalsobeaddressed.ThefocuswillconsidervariousaspectsofRTincludingstrategiestoreducethevolumeoftissuebeingirradiated,dose,scheduling,andthepossibleofomissionofRTinselectedcases.Finally,technologyadvancesthroughtheuseofintensity-modulatedradiotherapy(IMRT),image-guidedIMRT,intraoperativeradiotherapy(IORT)andparticletherapywillalsobediscussed.

简介：Flowcytometryandimageanalysistechniquewereusedtoquantltatethenucleiofvarioussofttissuetumors.Asinglerepresentingsectionfromsofttissuesarcomawasusedforhistologicgrading.Histologlcandcytometriccomparativeanalysesshowedthatall21benigntumorswerediploid.Among62casesofsofttissuesarcoma,45(73%)wereaneuploid.Therewasasignificantdifferenceinthenuclearareabetweenbenignandmalignanttumors(P<0.01),dlploidandaneuploidtumors(P<0.05).ThetwonewtechniquesarevaluableIncellularquantitativemeasurementforsofttissuetumors.

简介：摘要Carbon monoxide (CO) poisoning is the leading cause of poisoning-related deaths globally. The currently available therapy options are normobaric oxygen (NBO) and hyperbaric oxygen (HBO). While NBO lacks in efficacy, HBO is not available in all areas and countries. We present a novel method, extracorporeal hyperoxygenation therapy (EHT), for the treatment of CO poisoning that eliminates the CO by treating blood extracorporeally at elevated oxygen partial pressure. In this study, we proof the principle of the method in vitro using procine blood: Firstly, we investigated the difference in the CO elimination of a hollow fibre membrane oxygenator and a specifically designed batch oxygenator based on the bubble oxygenator principle at elevated pressures (1, 3 bar). Secondly, the batch oxygenator was redesigned and tested for a broader range of pressures (1, 3, 5, 7 bar) and temperatures (23, 30, 37 ℃). So far, the shortest measured carboxyhemoglobin half-life in the blood was 21.32 min. In conclusion, EHT has the potential to provide an easily available and effective method for the treatment of CO poisoning.

简介：AbstractObjective:Medical data mining and sharing is an important process in E-Health applications. However, because these data consist of a large amount of personal private information of patients, there is the risk of privacy disclosure when sharing and mining. Therefore, ensuring the security of medical big data in the process of publishing, sharing, and mining has become the focus of current research. The objective of our study is to design a framework based on a differential privacy protection mechanism to ensure the secure sharing of medical data. We developed a privacy protection query language (PQL) that integrates multiple data mining methods and provides a secure sharing function.Methods:This study is mainly performed in Xuzhou Medical University, China and designs three sub-modules: a parsing module, mining module, and noising module. Each module encapsulates different computing methods, such as a composite parser and a noise theory. In the PQL framework, we apply the differential privacy theory to the results of the computing between modules to guarantee the security of various mining algorithms. These computing devices operate independently, but the mining results depend on their cooperation. In addition, PQL is encapsulated in MNSSp3 that is a data mining and security sharing platform and the data comes from public data sets, such as UCBI. The public data set (NCBI database) was used as the experimental data, and the data collection time was January 2020.Results:We designed and developed a query language that provides functions for medical data mining, sharing, and privacy preservation. We theoretically proved the performance of the PQL framework. The experimental results show that the PQL framework can ensure the security of each mining result and the availability of the output results is above 97%.Conclusion:Our framework enables medical data providers to securely share health data or treatment data and develops a usable query language, based on a differential privacy mechanism, that enables researchers to mine information securely using data mining algorithms.

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简介：摘要目的观察soft-start光聚合技术在全瓷修复体粘接中的应用效果。方法取2015年4月—2016年12月医院收治正畸治疗需要拔出第一前磨牙采用光固化复合树脂填充治疗患者60例，随机数字法分为对照组（n=30）和观察组（n=30）。对照组采用高强度光聚合模式治疗，观察组采用soft-start光聚合技术治疗，比较两组临床疗效。结果观察组治疗后28例治疗成功，成功率为93.33%，对照组治疗后22例成功，成功率为73.33%，两组疗效率比较差异有统计学意义（P<0.05）；对两组进行6个月随访，两组均未发生并发症（P>0.05）。结论正畸治疗需要拔出第一前磨牙采用光固化复合树脂填充治疗患者全瓷修复体粘接中采用soft-start光聚合技术治疗效果理想，值得推广应用。