简介:[摘要]本文主要介绍了各种杂质对PTK系列催化剂的影响进行了充分的阐述。
简介:摘要患者为26岁近视眼女性,右眼裸眼视力为0.1,左眼为0.2;左眼角膜有外伤史,鼻侧遗留角膜斑翳。经术前充分检查,右眼行飞秒激光辅助的准分子激光原位角膜磨镶术,左眼行准分子激光治疗性角膜切削术联合准分子激光角膜表面切削术。术后3个月患者双眼UCVA为1.2,左眼角膜瘢痕大部分消除。(中华眼科杂志,2021,57:614-617)
简介:ExposureofnaivemurineCD4^+TlymphocytestosuperantigensuchasstaphylococcalenterotoxinB(SEB)inducesastrongproliferativeresponse.ProlongedexposureorsubsequentrestimulationoftherespondingTcellpopulationwithSEBleadstotheapoptoticeventsofactivation-inducedcelldeath(AICD).ThesignalingmechanismresponsiblefortheAICDisatargetofintensiveinvestigation.However,theprecisedownstreamsignahngpathwaysofSEB-inducedAICDremainsunclear.Ourresultshereshowthatthesequentialactivationofcaspase-1/ICE-hkeandcaspase-3/CPP32-hkecysteineproteasesprobablyplaysaroleinthesignalingtransductionofSEB-inducedAICD,butcaspase-3/CPP32-hkeproteasesactivationdoesnotdependoncaspase-1-likeproteasesactivation.HerbimycinA,aspecificinhibitorofproteintyresinekinases,inhibitcaspase-3/CPP32-1ikecysteineproteasesactivation.However,itdoesnotpreventDNAfragmentationofCD4^+TcellsapoptosisinducedbySEB.TheseresultsindicatethatproteintyrosinekinasespathwayisprobablyinvolvedinthesignalingtransductionofCD4^+TcellsapoptosisinducedbySEBand“crosstalks”withthepathwayofcaspase-3/CPP32-1ikeproteasesactivation.